scholarly journals The Impact of 68Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours

2021 ◽  
Vol 12 ◽  
Author(s):  
Daniel J. Cuthbertson ◽  
Jorge Barriuso ◽  
Angela Lamarca ◽  
Prakash Manoharan ◽  
Thomas Westwood ◽  
...  
Keyword(s):  
Functional Imaging ◽  
Neuroendocrine Tumours ◽  
Locally Advanced ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Imaging Data ◽  
Cross Sectional ◽  
Pet Ct ◽  
Pancreatic Neuroendocrine Tumours ◽  
The Impact

ObjectivePancreatic neuroendocrine tumours (panNETs) arise sporadically or as part of a genetic predisposition syndrome. CT/MRI, endoscopic ultrasonography and functional imaging using Octreoscan localise and stage disease. This study aimed to evaluate the complementary role of 68Gallium (68Ga)-DOTA PET/CT in managing patients with panNETs.DesignA retrospective study conducted across three tertiary UK NET referral centres.MethodsDemographic, clinical, biochemical, cross-sectional and functional imaging data were collected from patients who had undergone a 68Ga-DOTA PET/CT scan for a suspected panNET.ResultsWe collected data for 183 patients (97 male): median (SD) age 63 (14.9) years, 89.1 vs. 9.3% (n=163 vs. 17) alive vs. dead (3 data missing), 141 sporadic vs. 42 familial (MEN1, n=36; 85.7%) panNETs. Non-functional vs. functional tumours comprised 73.2 vs. 21.3% (n=134 vs. 39) (10 missing). Histological confirmation was available in 89% of individuals (n=163) but tumour grading (Ki67 classiifcation) was technically possible only in a smaller cohort (n=143): grade 1, 50.3% (n=72); grade 2, 46.2% (n=66) and grade 3, 3.5% (n=5) (40 histopathological classification either not technically feasible or biopsy not perfomed). 60.1% (n=110) were localised, 14.2% (n=26) locally advanced and 23.5% (n=43) metastatic (4 missing). 224 68Ga-DOTA PET/CT scans were performed in total for: diagnosis/staging 40% (n=88), post-operative assessment/clinical surveillance 53% (n=117) and consideration of peptide receptor radionuclide therapy (PRRT) 8% (n=17) (2 missing). PET/CT results confirmed other imaging findings (53%), identified new disease sites (28.5%) and excluded suspected disease (5%). Overall, 68Ga-DOTA PET/CT imaging findings provided additional information in 119 (54%) patients and influenced management in 85 (39%) cases.Conclusion68Ga-DOTA PET/CT imaging more accurately stages and guides treatment in patients with sporadic/familial panNETs with newly diagnosed/recurrent disease.

The impact of 68Ga-based PET-CT scanning on the management of patients with sporadic pancreatic neuroendocrine tumours (pNETs)

2018 ◽  
Author(s):  
Daniel Cuthbertson ◽  
Jorge Barriuso ◽  
Michail Pizanais ◽  
Matthew Jaffa ◽  
Angela Lamarca ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Ct Scanning ◽  
Pet Ct ◽  
Pancreatic Neuroendocrine Tumours ◽  
The Impact

The impact of 68Ga-based PET-CT scanning on the management of patients with familial pancreatic neuroendocrine tumours (panNETs)

2018 ◽  
Author(s):  
Daniel Cuthbertson ◽  
Jorge Barriuso ◽  
Michail Pizanias ◽  
Matthew Jaffa ◽  
Christina Nuttall ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Ct Scanning ◽  
Pet Ct ◽  
Pancreatic Neuroendocrine Tumours ◽  
The Impact

scholarly journals 18F-FDG PET/CT imaging findings of multiple solitary fibrous tumor

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16743
Author(s):  
Xiaofei Liu ◽  
Wenhua Zhu ◽  
Xiaohong Zhou ◽  
Hao Yao ◽  
Jiagui Su ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fibrous Tumor ◽  
Fdg Pet Ct

Role of 68Ga-DOTATOC PET-CT in the diagnosis and staging of pancreatic neuroendocrine tumours

2011 ◽  
Vol 21 (11) ◽  
pp. 2408-2416 ◽  
Author(s):  
Rakesh Kumar ◽  
Punit Sharma ◽  
Pramod Garg ◽  
Sellam Karunanithi ◽  
Niraj Naswa ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Pet Ct ◽  
Pancreatic Neuroendocrine Tumours

scholarly journals An Assessment of the Impact of Incorporating Time-of-Flight Information into Clinical PET/CT Imaging

2010 ◽  
Vol 51 (2) ◽  
pp. 237-245 ◽  
Author(s):  
C. Lois ◽  
B. W. Jakoby ◽  
M. J. Long ◽  
K. F. Hubner ◽  
D. W. Barker ◽  
...  
Keyword(s):  
Time Of Flight ◽  
Ct Imaging ◽  
Pet Ct ◽  
The Impact

scholarly journals Correlation of clinical outcomes with bremsstrahlung and Y-90 PET/CT imaging findings following Y-90 radiosynoviorthesis: a prospective study

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Thomas W. Barber ◽  
Martin H. Cherk ◽  
Anne Powell ◽  
Kenneth S. K. Yap ◽  
Baki Billah ◽  
...  
Keyword(s):  
Prospective Study ◽  
Clinical Outcomes ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Pet Ct ◽  
A Prospective Study

scholarly journals FDG-PET/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience

2021 ◽  
Vol 11 ◽  
Author(s):  
Clelia Di Carlo ◽  
Maika di Benedetto ◽  
Lisa Vicenzi ◽  
Sara Costantini ◽  
Francesca Cucciarelli ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Anal Cancer ◽  
Dose Escalation ◽  
Locally Advanced ◽  
Target Volume ◽  
Target Volume Delineation ◽  
18Fdg Pet ◽  
Volume Delineation ◽  
Pet Ct ◽  
The Impact

AimsRadiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy has been established as definitive standard therapy approach for anal cancer. Intensity Modulated Radiotherapy (IMRT) leads to a precise treatment of the tumor, allowing dose escalation on Gross Tumor Volume (GTV), with a surrounding healthy tissues sparing. Our study assessed the impact of 18-Fluorodeoxyglucose positron emission tomography (18FDG-PET/CT) on the radiotherapy contouring process and its contribution to lymphatic spread detection, resulting to a personalization of Clinical Target Volume (CTV) and dose prescription.MethodsThirty-seven patients, with histologically proven squamous cell carcinoma of the anal canal (SCCAC) were analyzed. All patients were evaluated with history and physical examination, trans-anal endoscopic ultrasound, pelvis magnetic resonance imaging (MRI), computed tomography (CT) scans of the chest, abdomen and pelvis and planning 18FDG-PET/CT. The GTV and CTV were drawn on CT, MRI and 18FDG-PET/CT fused images.ResultsThirty-four (91%) out of 37 patients presented lymph nodes involvement, in one or more areas, detected on 18FDG-PET/CT and/or MRI. The 18FDG-PET/CT showed positive lymph nodes not detected on MRI imaging (PET+, MRI−) in 14/37 patients (38%). In 14 cases, 18FDG-PET/CT allowed to a dose escalation in the involved nodes. The 18FDG-PET/CT fused images led to change the stage in 5/37(14%) cases: four cases from N0 to N1 (inguinal lymph nodes) and in one case from M0 to M1 (common iliac lymph nodes).ConclusionsThe 18FDG-PET/CT has a potentially relevant impact in staging and target volume delineation/definition in patients affected by anal cancer. In our experience, clinical stage variation occurred in 14% of cases. More investigations are needed to define the role of 18FDG-PET/CT in the target volume delineation of anal cancer.

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