scholarly journals The Role of Innate Lymphoid Cells in Immune-Mediated Liver Diseases

2017 ◽  
Vol 8 ◽  
Author(s):  
Meifang Liu ◽  
Cai Zhang
Keyword(s):  
Liver Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

scholarly journals An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Silvia Sedda ◽  
Irene Marafini ◽  
Michele M. Figliuzzi ◽  
Francesco Pallone ◽  
Giovanni Monteleone
Keyword(s):  
Transcription Factor ◽  
Decisive Role ◽  
Innate Lymphoid Cells ◽  
Small Population ◽  
Lymphoid Cells ◽  
Antigen Receptors ◽  
Immune Mediated ◽  
Lymphoid Organogenesis

Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of phenotypic and functional criteria and termed ILCs1, ILCs2, and ILCs3. Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORαand express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ. ILCs represent a relatively small population in the gut, but accumulating evidence suggests that these cells could play a decisive role in orchestrating both protective and detrimental immune responses. In this review, we will summarize the present knowledge on the distribution of ILCs in the intestinal mucosa, with particular focus on their role in the control of both infections and effector cytokine response in immune-mediated pathologies.

scholarly journals A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis

2016 ◽  
Vol 198 (1) ◽  
pp. 128-137 ◽  
Author(s):  
Katrin Neumann ◽  
Khalil Karimi ◽  
Jana Meiners ◽  
Ruth Voetlause ◽  
Silja Steinmann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated ◽  
Proinflammatory Role

Role of Type 2 Innate Lymphoid Cells and the Alarmin IL-33 in a Mouse Model of Immune-Mediated Hepatitis

2016 ◽  
Vol 64 (2) ◽  
pp. S517
Author(s):  
K. Neumann ◽  
K. Karimi ◽  
J. Meiners ◽  
R. Voetlause ◽  
W. Dammermann ◽  
...  
Keyword(s):  
Mouse Model ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

scholarly journals The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

2021 ◽  
Author(s):  
Paula Ruibal ◽  
Linda Voogd ◽  
Simone A. Joosten ◽  
Tom H. M. Ottenhoff
Keyword(s):  
T Cells ◽  
Nk Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells

scholarly journals Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis

2020 ◽  
Vol 32 (6) ◽  
pp. 407-419 ◽  
Author(s):  
Yurina Miyajima ◽  
Kafi N Ealey ◽  
Yasutaka Motomura ◽  
Miho Mochizuki ◽  
Natsuki Takeno ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Adipocyte Differentiation ◽  
Allergic Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Brown Adipocytes ◽  
Morphogenetic Protein ◽  
Group 2

Abstract Group 2 innate lymphoid cells (ILC2s) are type 2 cytokine-producing cells that have important roles in helminth infection and allergic inflammation. ILC2s are tissue-resident cells, and their phenotypes and roles are regulated by tissue-specific environmental factors. While the role of ILC2s in the lung, intestine and bone marrow has been elucidated in many studies, their role in adipose tissues is still unclear. Here, we report on the role of ILC2-derived bone morphogenetic protein 7 (BMP7) in adipocyte differentiation and lipid accumulation. Co-culture of fat-derived ILC2s with pluripotent mesenchymal C3H10T1/2 cells and committed white preadipocyte 3T3-L1 cells resulted in their differentiation to adipocytes and induced lipid accumulation. Co-culture experiments using BMP7-deficient ILC2s revealed that BMP7, produced by ILC2s, induces differentiation into brown adipocytes. Our results demonstrate that BMP7, produced by ILC2s, affects adipocyte differentiation, particularly in brown adipocytes.

scholarly journals Role of innate lymphoid cells in allergic diseases

2019 ◽  
Vol 40 (3) ◽  
pp. 138-145 ◽  
Author(s):  
M. Asghar Pasha ◽  
Gargi Patel ◽  
Russell Hopp ◽  
Qi Yang
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Food Allergies ◽  
Antigen Receptors ◽  
Medline Search ◽  
Allergic Disorders

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

scholarly journals Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen

npj Vaccines ◽  
2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Shengtao Fan ◽  
Yun Liao ◽  
Yaru Lian ◽  
Guorun Jiang ◽  
Li Jiang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Intradermal Immunization
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