scholarly journals Human Schwann Cell Transplantation for Spinal Cord Injury: Prospects and Challenges in Translational Medicine

2021 ◽  
Vol 15 ◽  
Author(s):  
Paula V. Monje ◽  
Lingxiao Deng ◽  
Xiao-Ming Xu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Relevant Literature ◽  
Basic Research ◽  
Preclinical Model ◽  
Cord Injury ◽  
Cultured Schwann Cells ◽  
The Usa ◽  
Traditional Processing ◽  
Hsc Transplantation

The benefits of transplanting cultured Schwann cells (SCs) for the treatment of spinal cord injury (SCI) have been systematically investigated in experimental animals since the early 1990s. Importantly, human SC (hSC) transplantation for SCI has advanced to clinical testing and safety has been established via clinical trials conducted in the USA and abroad. However, multiple barriers must be overcome to enable accessible and effective treatments for SCI patients. This review presents available information on hSC transplantation for SCI with the intention to uncover gaps in our knowledge and discuss areas for future development. To this end, we introduce the historical progression of the work that supports existing and prospective clinical initiatives and explain the reasons for the choice of hSCs while also addressing their limitations as cell therapy products. A search of the relevant literature revealed that rat SCs have served as a preclinical model of reference since the onset of investigations, and that hSC transplants are relatively understudied, possibly due to the sophisticated resources and expertise needed for the traditional processing of hSC cultures from human nerves. In turn, we reason that additional experimentation and a reexamination of the available data are needed to understand the therapeutic value of hSC transplants taking into consideration that the manufacturing of the hSCs themselves may require further development for extended uses in basic research and clinical settings.

scholarly journals Association Between Trauma Center Designation and Spinal Cord Injury Admission in the USA

2020 ◽  
Vol 10 (5) ◽  
pp. 193-198
Author(s):  
Ross-Jordon S. Elliott ◽  
Anand Dharia ◽  
Ali Seifi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Trauma Center ◽  
Cord Injury ◽  
The Usa

Ac-SDKP peptide improves functional recovery following spinal cord injury in a preclinical model

Neuropeptides ◽  
2022 ◽  
pp. 102228
Author(s):  
Shiva Hashemizadeh ◽  
Soheila Pourkhodadad ◽  
Saereh Hosseindoost ◽  
Sina Pejman ◽  
Maryam Kamarehei ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Preclinical Model ◽  
Cord Injury

The Influence of Spinal Cord Injury on Coping Styles and Self-Perceptions: A Controlled Study

1993 ◽  
Vol 27 (3) ◽  
pp. 450-456 ◽  
Author(s):  
Karen Hancock ◽  
Ashley Craig ◽  
Chris Tennant ◽  
Esther Chang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Locus Of Control ◽  
Coping Styles ◽  
Self Esteem ◽  
Controlled Study ◽  
Cord Injury ◽  
The Usa ◽  
One Year ◽  
Injured Patients

Well-controlled research investigating psychological responses following Spinal Cord Injury (SCI) is lacking. In addition, much of the literature is based on depression following SCI and is dominated by data from the USA. The effects of SCI on perceptions of control, self-esteem and coping styles over the first year of SCI were investigated. Forty-one acute spinal injured patients and 41 able-bodied controls matched for age, sex and education completed a variety of standardised questionnaires on three occasions over one year. The instruments included the Locus of Control of Behaviour Scale, Rosenberg's Self-Esteem Scale, and an adapted Mental Adjustment to Cancer (MAC) Scale which measures coping styles, including fighting spirit, helplessness/hopelessness and fatalism. The SCI group were found to be more external in their perceptions of control, lower in self-esteem, and more helpless/hopeless and fatalistic in attitude than the controls. The majority of the SCI group had scores reflecting adaptive coping styles and intact levels of self-esteem but there were still a substantial proportion who displayed maladaptive coping styles (e.g. external locus of control, fatalism, helplessness). No differences in scores across time were found for either group. Implications for psychological rehabilitation are discussed.

Epidemiology of Current Treatment for Sexual Dysfunction in Spinal Cord Injured Men in the USA Model Spinal Cord Injury Centers

1996 ◽  
Vol 19 (3) ◽  
pp. 186-189 ◽  
Author(s):  
Toyohiko Watanabe ◽  
Michael B. Chancellor ◽  
David A. Rivas ◽  
Irvin H. Hirsch ◽  
Carol J. Bennett ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Sexual Dysfunction ◽  
Current Treatment ◽  
Cord Injury ◽  
The Usa ◽  
Spinal Cord Injured

scholarly journals Risk factors for mortality after spinal cord injury in the USA

Spinal Cord ◽  
2013 ◽  
Vol 51 (5) ◽  
pp. 413-418 ◽  
Author(s):  
Y Cao ◽  
J S Krause ◽  
N DiPiro
Keyword(s):  
Risk Factors ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
The Usa

scholarly journals Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1907 ◽  
Author(s):  
Antigona Ulndreaj ◽  
Anna Badner ◽  
Michael G Fehlings
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Treatment Options ◽  
Basic Research ◽  
Traumatic Spinal Cord Injury ◽  
Preclinical Research ◽  
Cord Injury ◽  
Neuroprotective Strategies ◽  
Hypertensive Therapy ◽  
Cervical Level

Traumatic spinal cord injury (SCI) is a devastating condition of motor, sensory, and autonomic dysfunction. The significant cost associated with the management and lifetime care of patients with SCI also presents a major economic burden. For these reasons, there is a need to develop and translate strategies that can improve outcomes following SCI. Given the challenges in achieving regeneration of the injured spinal cord, neuroprotection has been at the forefront of clinical translation. Yet, despite many preclinical advances, there has been limited translation into the clinic apart from methylprednisolone (which remains controversial), hypertensive therapy to maintain spinal cord perfusion, and early decompressive surgery. While there are several factors related to the limited translational success, including the clinical and mechanistic heterogeneity of human SCI, the misalignment between animal models of SCI and clinical reality continues to be an important factor. Whereas most clinical cases are at the cervical level, only a small fraction of preclinical research is conducted in cervical models of SCI. Therefore, this review highlights the most promising neuroprotective and neural reparative therapeutic strategies undergoing clinical assessment, including riluzole, hypothermia, granulocyte colony-stimulating factor, glibenclamide, minocycline, Cethrin (VX-210), and anti-Nogo-A antibody, and emphasizes their efficacy in relation to the anatomical level of injury. Our hope is that more basic research will be conducted in clinically relevant cervical SCI models in order to expedite the transition of important laboratory discoveries into meaningful treatment options for patients with SCI.

scholarly journals Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Munehisa Shinozaki ◽  
Yuichiro Takahashi ◽  
Masahiko Mukaino ◽  
Nobuhito Saito ◽  
Yoshiaki Toyama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Open Field ◽  
Injury Severity ◽  
Basic Research ◽  
Maximum Speed ◽  
Adult Mice ◽  
Cord Injury ◽  
Novel Method ◽  
Novel Concept

In basic research on spinal cord injury (SCI), behavioral evaluation of the SCI animal model is critical. However, it is difficult to accurately evaluate function in the mouse SCI model due to the small size of mice. Although the open-field scoring scale is an outstanding appraisal method, supplementary objective tests are required. Using a compact SCANET system, in which a mouse carries out free movement for 5 min, we developed a novel method to detect locomotor ability. A SCANET system samples the horizontal coordinates of a mouse every 0.1 s, and both the speed and acceleration of its motion are calculated at each moment. It was found that the maximum speed and acceleration of motion over 5 min varied by injury severity. Moreover, these values were significantly correlated with open-field scores. The maximum speed and acceleration of SCI model mice using a SCANET system are objective, easy to obtain, and reproducible for evaluating locomotive function.

scholarly journals Cell Transplantation for Spinal Cord Injury: A Systematic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-32 ◽  
Author(s):  
Jun Li ◽  
Guilherme Lepski
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Protein Interactions ◽  
Basic Research ◽  
Cellular Behavior ◽  
Cord Injury

Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years. A number of different kinds of stem cells, neural progenitors, and glial cells have been tested in basic research, and most have been excluded from clinical studies because of a variety of reasons, including safety and efficacy. The signaling pathways, protein interactions, cellular behavior, and the differentiated fates of experimental cells have been studiedin vitroin detail. Furthermore, the survival, proliferation, differentiation, and effects on promoting functional recovery of transplanted cells have also been examined in different animal SCI models. However, despite significant progress, a “bench to bedside” gap still exists. In this paper, we comprehensively cover publications in the field from the last years. The most commonly utilized cell lineages were covered in this paper and specific areas covered include survival of grafted cells, axonal regeneration and remyelination, sensory and motor functional recovery, and electrophysiological improvements. Finally we also review the literature on thein vivotracking techniques for transplanted cells.

Sign in / Sign up

Export Citation Format

Share Document