Internally Guided Lower Limb Movement Recruits Compensatory Cerebellar Activity in People With Parkinson's Disease

ABSTRACTBackgroundMotor and cognitive dysfunction has been linked in patients with Parkinson’s disease (PD). EEG theta and beta rhythms are reliably associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal beta and theta rhythms in the mid-frontal region during action initiation.MethodsWe recruited thirty-nine subjects, including PD patients with FOG (PDFOG+; n=13) and without FOG (PDFOG−; n=13), and demographically-matched healthy subjects (n=13). Scalp electroencephalogram (EEG) signals were collected during a lower-limb pedaling motor task, which required intentional initiation and stopping of a motor movement.ResultsFOG scores were correlated with disease severity and cognition. PDFOG+ patients pedaled with reduced speed and decreased acceleration compared to PDFOG− patients and to controls. PDFOG+ patients exhibited attenuated theta-band (4-8 Hz) power and increased beta-band (13-30 Hz) power at mid-frontal electrode Cz during pedaling. Frontal theta- and beta-band oscillations also correlated with lower-limb movement in PD patients.ConclusionsFrontal theta and beta oscillations are predictors of lower-limb motor symptoms in PD. These data provide insight into the mechanism of lower-limb dysfunction in PD, and could be used to design neuromodulation for PD-related lower-limb abnormalities.

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Transmission of group II heteronymous pathways is enhanced in rigid lower limb of de novo patients with Parkinson's disease

Brain ◽

10.1093/brain/awf201 ◽

2002 ◽

Vol 125 (9) ◽

pp. 2125-2133 ◽

Cited By ~ 21

Author(s):

M. Simonetta Moreau

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Lower Limb ◽

De Novo ◽

Group Ii

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QUANTITATIVE ASSESSMENT OF DANCE THERAPY INFULENCE ON THE PARKINSON’S DISEASE PATIENTS’ LOWER LIMB BIOMECHANICS / ŠOKIŲ ĮTAKA APATINIŲ GALŪNIŲ BIOMECHANIKAI SERGANT PARKINSONO LIGA

Mokslas - Lietuvos ateitis ◽

10.3846/mla.2016.978 ◽

2017 ◽

Vol 8 (6) ◽

pp. 583-586

Author(s):

Donatas Lukšys ◽

Julius Griškevičius

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Lower Extremity ◽

Lower Limb ◽

Dance Therapy ◽

Inertial Sensors ◽

Dance Music ◽

Lindy Hop ◽

Spatio Temporal

Parkinson’s disease – progressive neurologic disorder that damages a variety of motor function and reduces the quality of life. Patients with PD are subject to various physical therapy exercises, but recently is applied more often the dance – music therapy. This study aims assessing the therapeutic effect of the modified Lindy Hop dance therapy on lower extremity biomechanics. The experimental study was performed using inertial sensors that registered lower extremity biomechanical parameters during gait. Several spatio-temporal parameters of lower limb were calculated and were found statistically significant between groups, which allows quantifying the influence of dance therapy. Parkinsono liga (PL) – progresuojantis neurologinis sutrikimas, kuris pažeidžia įvairias motorines funkcijas ir sumažina gyvenimo kokybę. Sergant PL, taikomos įvairios fizinių pratimų terapijos, bet paskutiniu metu dažniau taikoma šokių – muzikos – terapija. Eksperimentinio tyrimo metu buvo naudojami inerciniai jutikliai, siekiant registruoti apatinių galūnių biomechaninius parametrus eisenos metu. Šio straipsnio tikslas – įvertinti modifikuotos lindihopo šokių terapijos įtaką apatinių galūnių biomechanikai. Buvo apskaičiuoti apatinių galūnių kinematiniai parametrai ir surasti statistiškai reikšmingi skirtumai tarp grupių ir grupių viduje, kurie leidžia kiekybiškai įvertinti šokių įtaką.

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