scholarly journals Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

2019 ◽  
Author(s):  
Arun Singh ◽  
Rachel C. Cole ◽  
Arturo I. Espinoza ◽  
Darin Brown ◽  
James F. Cavanagh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Limb ◽  
Motor Task ◽  
Limb Movement ◽  
Beta Band ◽  
Beta Oscillations ◽  
Frontal Electrode ◽  
Lower Limb Movement ◽  
Scalp Electroencephalogram

ABSTRACTBackgroundMotor and cognitive dysfunction has been linked in patients with Parkinson’s disease (PD). EEG theta and beta rhythms are reliably associated with cognitive and motor functions, respectively. We tested the hypothesis that PD patients with lower-limb abnormalities would exhibit abnormal beta and theta rhythms in the mid-frontal region during action initiation.MethodsWe recruited thirty-nine subjects, including PD patients with FOG (PDFOG+; n=13) and without FOG (PDFOG−; n=13), and demographically-matched healthy subjects (n=13). Scalp electroencephalogram (EEG) signals were collected during a lower-limb pedaling motor task, which required intentional initiation and stopping of a motor movement.ResultsFOG scores were correlated with disease severity and cognition. PDFOG+ patients pedaled with reduced speed and decreased acceleration compared to PDFOG− patients and to controls. PDFOG+ patients exhibited attenuated theta-band (4-8 Hz) power and increased beta-band (13-30 Hz) power at mid-frontal electrode Cz during pedaling. Frontal theta- and beta-band oscillations also correlated with lower-limb movement in PD patients.ConclusionsFrontal theta and beta oscillations are predictors of lower-limb motor symptoms in PD. These data provide insight into the mechanism of lower-limb dysfunction in PD, and could be used to design neuromodulation for PD-related lower-limb abnormalities.

scholarly journals Frontal theta and beta oscillations during lower-limb movement in Parkinson’s disease

2020 ◽  
Vol 131 (3) ◽  
pp. 694-702 ◽  
Author(s):  
Arun Singh ◽  
Rachel C. Cole ◽  
Arturo I. Espinoza ◽  
Darin Brown ◽  
James F. Cavanagh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Limb ◽  
Limb Movement ◽  
Beta Oscillations ◽  
Lower Limb Movement

scholarly journals Internally Guided Lower Limb Movement Recruits Compensatory Cerebellar Activity in People With Parkinson's Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Jonathan H. Drucker ◽  
K. Sathian ◽  
Bruce Crosson ◽  
Venkatagiri Krishnamurthy ◽  
Keith M. McGregor ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Limb ◽  
Limb Movement ◽  
Lower Limb Movement

scholarly journals Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

2021 ◽  
Author(s):  
David Escobar Sanabria ◽  
Joshua E Aman ◽  
Valentina Zapata Amaya ◽  
Luke A Johnson ◽  
Hafsa Farooqi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Real Time ◽  
Brain Stimulation ◽  
Neural Activity ◽  
Beta Band ◽  
Beta Oscillations ◽  
Oscillatory Dynamics ◽  
Deep Brain

Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical stimulation with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Amplification of targeted oscillations led to an increase in the variance of motor tracking delays, supporting the hypothesis that pallidal beta oscillations are linked to motor performance. Our results highlight the utility of eiDBS to characterize the pathophysiology of PD and other brain conditions in the human and develop personalized neuromodulation therapies.

scholarly journals Altered cerebellar oscillations in Parkinson's disease patients during cognitive and motor tasks

2021 ◽  
Author(s):  
Taylor Bosch ◽  
Christopher Groth ◽  
Tiffany Eldridge ◽  
Etienne Gnimpieba ◽  
Lee Baugh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Limb ◽  
Motor Task ◽  
Interval Timing ◽  
Oscillatory Activity ◽  
Alpha Power ◽  
Theta Band ◽  
Motor Tasks ◽  
Band Power

Structural and functional abnormalities in the cerebellar region have been shown in patients with Parkinson's disease (PD). Since the cerebellar region has been associated with cognitive and lower-limb motor functions, it is imperative to study cerebellar oscillations in PD. Here, we evaluated cerebellar electroencephalography (EEG) during cognitive processing and lower-limb motor performances in PD. Cortical and cerebellar EEG were collected from 74 PD patients and 37 healthy control subjects during a 7-second interval timing task, 26 PD patients and 13 controls during a lower-limb pedaling task, and 23 PD patients during eyes-open/closed resting conditions. Analyses were focused on the mid-cerebellar Cbz electrode and further compared to the mid-occipital Oz and mid-frontal Cz electrodes. Increased alpha-band power was observed during the eyes-closed resting-state condition over Oz, but no change in alpha power was observed over Cbz. PD patients showed higher dispersion when performing the 7-second interval timing cognitive task and executed the pedaling motor task with reduced speed compared to controls. PD patients exhibited attenuated cue-triggered theta-band power over Cbz during both the interval timing and pedaling motor tasks. Connectivity measures between Cbz and Cz showed theta-band differences, but only during the pedaling motor task. Cbz oscillatory activity also differed from Oz across multiple frequency bands in both groups during both tasks. Our cerebellar EEG data along with previous magnetoencephalography and animal model studies clearly show the alteration in the cerebellar oscillations during cognitive and motor processing in PD.

Synchronized cortico-subthalamic beta oscillations in Parkin-associated Parkinson’s disease

2015 ◽  
Vol 126 (11) ◽  
pp. 2241-2243 ◽  
Author(s):  
Christian K.E. Moll ◽  
Carsten Buhmann ◽  
Alessandro Gulberti ◽  
Ulrich Fickel ◽  
Monika Poetter-Nerger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Oscillations

scholarly journals Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease

2020 ◽  
Author(s):  
Abhinav Sharma ◽  
Diego Vidaurre ◽  
Jan Vesper ◽  
Alfons Schnitzler ◽  
Esther Florin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Activity ◽  
Beta Band ◽  
Time Resolved ◽  
Functional Roles ◽  
Dopaminergic Medication ◽  
Physiological Processes ◽  
Motor Network ◽  
Theta Frequency

AbstractPathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson’s disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to communication within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with deteriorated frontal executive functioning as a side effect of dopamine treatment in Parkinson’s disease. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify locally-originating STN oscillations in PD. STN–STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.

scholarly journals QUANTITATIVE ASSESSMENT OF DANCE THERAPY INFULENCE ON THE PARKINSON’S DISEASE PATIENTS’ LOWER LIMB BIOMECHANICS / ŠOKIŲ ĮTAKA APATINIŲ GALŪNIŲ BIOMECHANIKAI SERGANT PARKINSONO LIGA

2017 ◽  
Vol 8 (6) ◽  
pp. 583-586
Author(s):  
Donatas Lukšys ◽  
Julius Griškevičius
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lower Extremity ◽  
Lower Limb ◽  
Dance Therapy ◽  
Inertial Sensors ◽  
Dance Music ◽  
Lindy Hop ◽  
Spatio Temporal

Parkinson’s disease – progressive neurologic disorder that damages a variety of motor function and reduces the quality of life. Patients with PD are subject to various physical therapy exercises, but recently is applied more often the dance – music therapy. This study aims assessing the therapeutic effect of the modified Lindy Hop dance therapy on lower extremity biomechanics. The experimental study was performed using inertial sensors that registered lower extremity biomechanical parameters during gait. Several spatio-temporal parameters of lower limb were calculated and were found statistically significant between groups, which allows quantifying the influence of dance therapy. Parkinsono liga (PL) – progresuojantis neurologinis sutrikimas, kuris pažeidžia įvairias motorines funkcijas ir sumažina gyvenimo kokybę. Sergant PL, taikomos įvairios fizinių pratimų terapijos, bet paskutiniu metu dažniau taikoma šokių – muzikos – terapija. Eksperimentinio tyrimo metu buvo naudojami inerciniai jutikliai, siekiant registruoti apatinių galūnių biomechaninius parametrus eisenos metu. Šio straipsnio tikslas – įvertinti modifikuotos lindihopo šokių terapijos įtaką apatinių galūnių biomechanikai. Buvo apskaičiuoti apatinių galūnių kinematiniai parametrai ir surasti statistiškai reikšmingi skirtumai tarp grupių ir grupių viduje, kurie leidžia kiekybiškai įvertinti šokių įtaką.

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