scholarly journals Improving the Social Relevance of Experimental Stroke Models: Social Isolation, Social Defeat Stress and Stroke Outcome in Animals and Humans

2020 ◽  
Vol 11 ◽  
Author(s):  
Chloe A. Lowry ◽  
Albert Y. Jin
Keyword(s):  
Social Isolation ◽  
Social Defeat ◽  
Experimental Stroke ◽  
Stroke Outcome ◽  
Social Defeat Stress ◽  
Social Relevance ◽  
The Social ◽  
Stroke Models

scholarly journals Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

2016 ◽  
Vol 19 (12) ◽  
pp. pyw080 ◽  
Author(s):  
Bangkun Yang ◽  
Qian Ren ◽  
Min Ma ◽  
Qian-Xue Chen ◽  
Kenji Hashimoto
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Mk 801 ◽  
Antidepressant Effects ◽  
The Social

scholarly journals Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

2016 ◽  
Vol 233 (19-20) ◽  
pp. 3647-3657 ◽  
Author(s):  
Bangkun Yang ◽  
Ji-chun Zhang ◽  
Mei Han ◽  
Wei Yao ◽  
Chun Yang ◽  
...  
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Antidepressant Effects ◽  
The Social

scholarly journals Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress

2020 ◽  
Vol 11 ◽  
Author(s):  
Nobuhiko Ebisutani ◽  
Hirokazu Fukui ◽  
Heihachiro Nishimura ◽  
Takashi Nakanishi ◽  
Kenki Morimoto ◽  
...  
Keyword(s):  
Social Interaction ◽  
Epithelial Cells ◽  
Psychological Stress ◽  
Functional Gastrointestinal Disorders ◽  
Social Defeat ◽  
Sodium Concentration ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
The Social ◽  
Lovo Cells

Psychological stress is deeply involved in the pathophysiology of not only mental illness but also functional gastrointestinal disorders. In the present study, we examined the relationship between psychological stress and abnormality of stool properties, focusing on the alteration of plasma glucocorticoid and guanylin (GN)/uroguanylin (UGN) expression in the colon. A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. Thereafter the mice were kept in the same cage but separated by a divider for the remainder of the day. This procedure was repeated for 10 consecutive days, and then a social interaction test was performed to evaluate social avoidance. Fresh fecal and blood samples were collected for stool property analysis and measurement of the plasma glucocorticoid level by ELISA. The expression of GN, UGN, and guanylate cyclase 2C in the colonic tissues was examined by real-time RT-PCR and immunohistochemistry. Moreover, Lovo cells were stimulated with dexamethasone, and the expression of GN/UGN mRNA was examined. In the CSDS group, the time spent in the social interaction zone was significantly shorter when the CD-1 aggressor mouse was present than when it was absent. The social interaction ratio was also significantly lower in the CSDS group relative to the controls. The mean Bristol scale score was significantly lower in the CSDS group, but the fecal sodium concentration did not differ between CSDS mice and controls. The level of plasma corticosterone was significantly higher in the CSDS group than in the controls immediately after the 10th day of CSDS. The expression of both GN and UGN was significantly decreased in the CSDS mice. GN was expressed in all colonic epithelial cells, and UGN was expressed in ovoid or pyramidal epithelial cells in the colonic mucosa. The expression of both GN and UGN was significantly decreased in the CSDS mice relative to controls. The expression of both GN and UGN was significantly suppressed in Lovo cells upon stimulation with dexamethasone. Psychological stress-induced glucocorticoid may suppress colonic GN/UGN expression, resulting in a change in stool properties leading to constipation.

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression

2015 ◽  
Vol 232 (23) ◽  
pp. 4325-4335 ◽  
Author(s):  
Ji-chun Zhang ◽  
Wei Yao ◽  
Chao Dong ◽  
Chun Yang ◽  
Qian Ren ◽  
...  
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Antidepressant Effects ◽  
The Social

scholarly journals Development of a novel stress model using a video-recorded scene of the social defeat stress in mice

2021 ◽  
Vol 94 (0) ◽  
pp. 3-P1-15
Author(s):  
Yuko Nakatake ◽  
Hiroki Furuie ◽  
Masatoshi Ukezono ◽  
Misa Yamada ◽  
Kazumi Yoshizawa ◽  
...  
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
The Social

scholarly journals Ginsenoside Rb1 Produces Antidepressant-Like Effects in a Chronic Social Defeat Stress Model of Depression Through the BDNF–Trkb Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Ning Jiang ◽  
Hong Huang ◽  
Yiwen Zhang ◽  
Jingwei Lv ◽  
Qiong Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Social Defeat ◽  
Hippocampal Neurogenesis ◽  
Ginsenoside Rb1 ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
The Social ◽  
Immobility Time ◽  
Bdnf Signaling ◽  
The Impact

Ginsenoside Rb1 (Rb1), an important bioactive ingredient of Panax ginseng, has potent neuroprotective effects. The objective of the study is to elucidate the impact of Rb1 treatment on chronic social defeat stress (CSDS)–induced depressive-like behaviors and its related mechanism. According to the obtained results, the daily oral administration of Rb1 (35 and 70 mg/kg) and imipramine (15 mg/kg) for 28 days significantly reversed the social avoidance behavior, anhedonia, and behavioral despair via CSDS exposure, as demonstrated by the considerable elevation in the time in the zone in the social interaction test, consumption of sucrose solution in the sucrose preference test, and decrease in immobility time in the forced swim test. Moreover, Rb1 obviously restored the CSDS-induced decrease in the BDNF signaling pathway and hippocampal neurogenesis. Rb1 significantly increased the hippocampal levels of ERK, AKT, and CREB phosphorylation and increased the number of DCX+ cells in DG. Importantly, the antidepressant effects of Rb1 were completely blocked in mice by using K252a (the nonselective tyrosine kinase B inhibitor). In conclusion, our results indicated that Rb1 exerts promising antidepressant-like effects in mice with CSDS-induced depression, and its effects were facilitated by enhancing the BDNF signaling cascade and upregulation of hippocampal neurogenesis.

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