scholarly journals Topographic Quadrant Analysis of Peripapillary Superficial Microvasculature in Optic Disc Drusen

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Yan ◽  
Xiao Zhou ◽  
Zhongdi Chu ◽  
Laurel Stell ◽  
Mohammad Ali Shariati ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Function Analysis ◽  
Nerve Fibers ◽  
Quadrant Analysis ◽  
Mean Deviation ◽  
Structure Comparison ◽  
Parallel Change ◽  
Optic Disc Drusen ◽  
Temporal Quadrant

Background: Limited information is known about the topographic effect of optic disc drusen (ODD) on peripapillary retinal nerve fibers and microvasculature.Objective: This study aims to understand the structural and functional impact of ODD in different quadrants of the optic disc.Methods: We performed a retrospective case-control study of 22 ODD patients (34 eyes) and 26 controls (33 eyes) to compare optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), OCT angiography (OCTA), and corresponding static perimetry mean deviation (MD) calculated using the modified Garway-Heath map in different quadrants of the optic disc. OCTA was analyzed using custom MATLAB script to measure six parameters in a peripapillary annulus with large vessel removal: vessel area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI), vessel complexity index (VCI), flux, and vessel diameter index (VDI).Results: Quadrant analysis revealed that OCTA VAD and VCI were significantly decreased in superior, nasal, and inferior but not temporal quadrant. RNFL, VSD, and VPI were significantly impacted only in the superior and nasal quadrants. Corresponding visual field MDs in all ODD eyes were not different in the four quadrants, although eyes with MD equal or worse than −5 dB (32%) had worst visual field corresponding to the superior quadrant of the optic disc (inferior arcuate visual field). Structure-structure comparison of OCT and OCTA showed high correlation of RNFL with multiple OCTA measurements in the superior, nasal, and inferior quadrants but not temporal quadrant. Structure-function analysis revealed significant correlation of VAD and VCI and visual field MD in every quadrant, but RNFL was only significantly correlated in the superior and inferior quadrants.Conclusions: Peripapillary VAD and VCI are decreased in more quadrants than RNFL, supporting the clinical utility of performing OCTA in addition to OCT. Consistent with the most common locations of ODD, five OCT/OCTA measurements (VAD, VCI, RNFL, VSD, VPI) are decreased in the superior and nasal quadrants. OCT/OCTA measurements were significantly impacted in contrast to the relatively mild effect on corresponding visual field MD, consistent with the idea that a decrease in objective structural and vascular measurements occurs without parallel change in subjective visual function in ODD.

scholarly journals RetiNerveNet: using recursive deep learning to estimate pointwise 24-2 visual field data based on retinal structure

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shounak Datta ◽  
Eduardo B. Mariottoni ◽  
David Dov ◽  
Alessandro A. Jammal ◽  
Lawrence Carin ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Severe Disease ◽  
Nerve Fibers ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Fiber Layer ◽  
Floor Effect ◽  
Trade Offs

AbstractGlaucoma is the leading cause of irreversible blindness in the world, affecting over 70 million people. The cumbersome Standard Automated Perimetry (SAP) test is most frequently used to detect visual loss due to glaucoma. Due to the SAP test’s innate difficulty and its high test-retest variability, we propose the RetiNerveNet, a deep convolutional recursive neural network for obtaining estimates of the SAP visual field. RetiNerveNet uses information from the more objective Spectral-Domain Optical Coherence Tomography (SDOCT). RetiNerveNet attempts to trace-back the arcuate convergence of the retinal nerve fibers, starting from the Retinal Nerve Fiber Layer (RNFL) thickness around the optic disc, to estimate individual age-corrected 24-2 SAP values. Recursive passes through the proposed network sequentially yield estimates of the visual locations progressively farther from the optic disc. While all the methods used for our experiments exhibit lower performance for the advanced disease group (possibly due to the “floor effect” for the SDOCT test), the proposed network is observed to be more accurate than all the baselines for estimating the individual visual field values. We further augment the proposed network to additionally predict the SAP Mean Deviation values and also facilitate the assignment of higher weightage to the underrepresented groups in the data. We then study the resulting performance trade-offs of the RetiNerveNet on the early, moderate and severe disease groups.

Optic Disc Drusen: Longitudinal Aspects, with Emphasis on Visual Field Constriction and Enlarged Blind Spot: A Retrospective Hospital-Based Clinical Series

2016 ◽  
Vol 27 (3) ◽  
pp. 372-378 ◽  
Author(s):  
Hans C. Fledelius
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Blind Spot ◽  
Observation Time ◽  
Main Trend ◽  
Visual Field Defects ◽  
Optic Disc Drusen ◽  
Clinical Series ◽  
Field Defects ◽  
Visual Field Constriction

Purpose To examine long-term data on optic disc drusen (ODD) from an outpatient hospital series that indicated more cases with advanced visual field constriction than is apparent from other clinical reports. The underlying pathophysiology is discussed, also with regard to enlarged blind spot, which, in view of the small disc at risk, may seem a paradox. Methods This is an observational retrospective study on an eye clinic series (n = 49), focusing on visual acuity, kinetic/static perimetry, and longitudinal trends, to include the question of eventual visual incapacity. Results Forty-nine patients (32 female and 17 male; bilateral ODD in 45) aged 5-76 years (median age 29 years for both sexes) were included in the study. Observation time was 1-54 years, with serial data recorded over at least 3 years in 25 patients. Visual field defects were found in 32 patients, with ODD considered responsible for the visual field defects demonstrated. Advanced unilateral concentric constriction (for the largest Goldmann object) was recorded in 10 patients, and bilaterally in 2. With regard to nonexplanatory side diagnoses, 2 patients had pituitary adenoma, 1 had a cavernous sinus meningioma, and 1 had neurosurgery for an arachnoid cyst. Conclusions We found more cases of marked visual field constriction than reported in other clinical series. A few such cases appeared acute and vascular, but the main trend was clinically quiet over time. All 49 patients could manage visually in daily life.

Progressive Visual Field Loss Associated with Optic Disc Drusen over 25 Years

2010 ◽  
Vol 42 ◽  
pp. e1-e4
Author(s):  
Ioannis Emfietzoglou ◽  
Vlassis Grigoropoulos ◽  
Ioannis Vergados ◽  
Pandelis Nikolaidis ◽  
Ioannis Halkiadakis ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Visual Field Loss ◽  
Optic Disc Drusen

Optic Disc Drusen in Tilted Disc

2005 ◽  
Vol 15 (5) ◽  
pp. 647-651 ◽  
Author(s):  
G. Giuffrè
Keyword(s):  
Congenital Anomaly ◽  
Risk Factor ◽  
Optic Nerve ◽  
Optic Disc ◽  
Lamina Cribrosa ◽  
Nerve Fibers ◽  
Optic Disc Drusen ◽  
Fundus Photographs ◽  
Tilted Disc ◽  
Optic Nerve Drusen

Purpose To investigate if a congenital anomaly of the head of the optic nerve like such as tilted disc can be a risk factor for the development of optic disc drusen. Methods The study was performed retrospectively on the files of 47 patients with optic disc drusen. The diagnosis was confirmed by fluorescein angiography and B-scan ultrasonography. The authors examined the fundus photographs and the fluorescein angiographies of these patients looking for the presence of tilted discs. Results Two of the 47 patients with optic nerve drusen had tilted discs as well, about twice the expected rate. Both cases presented a parapapillary hemorrhage. Conclusions The concomitant presence of tilted disc and optic disc drusen can have a cause-effect relationship. The axonal crowding in a scleral canal of reduced size, as seen in tilted disc, can compress the nerve fibers against the stiff lamina cribrosa, producing a chronic optic neuropathy leading to drusen.

scholarly journals Retinal hemorrhages as one of complications of optic disc drusen during pregnancy

2014 ◽  
Vol 67 (5-6) ◽  
pp. 185-189
Author(s):  
Marija Trenkic-Bozinovic ◽  
Predrag Jovanovic ◽  
Gordana Zlatanovic ◽  
Dragan Veselinovic ◽  
Aleksandra Aracki-Trenkic ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Visual Field ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Ganglion Cells ◽  
Therapeutic Interventions ◽  
Visual Field Defects ◽  
Retinal Hemorrhages ◽  
Optic Disc Drusen

Introduction. Drusen of the optic nerve head are relatively benign and asymptomatic. They represent retinal hyaline corpuscles resulting from impaired axoplasmic transport of the retinal ganglion cells of optic nerve in front of the lamina cribrosa. They are usually detected accidentally, during a routine ophthalmologic examination. Most patients with optic disc drusen are not aware of the deterioration of their eyesight because of the slow progression of visual field defects. Damage in visual acuity due to optic disc drusen is rare. Case Report. A 27-year-old female patient in the sixth month of pregnancy visited an ophthalmologist because of a visual impairment described as the appearance of mist and shadows over her right eye. When first examined, her visual acuity in both eyes was 20/20. The retinal hemorrhages framing the bottom half of the optic nerve were seen. Complete laboratory and clinical testing as well as specific ophthalmic examinations (photofundus, computerized visual field, optical coherence tomography, and ultrasound) were performed to exclude systemic causes and they presented no risk for the pregnancy. Echosonographic examination confirmed the presence of bilateral optic nerve head drusen. Conclusion. Hemodynamic changes during pregnancy are possible factors for the development of optical disc and retinal hemorrhages. Since treatment of optic disc drusen is limited, recognition of optic nerve drusen as a cause of hemorrhage during pregnancy prevents unnecessary diagnostic and therapeutic interventions.

Substantial Visual Field Loss Associated With Giant Optic Disc Drusen

2017 ◽  
Vol 135 (12) ◽  
pp. e174778 ◽  
Author(s):  
Lasse Malmqvist ◽  
Alexander Kyhnel ◽  
Steffen Hamann
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Visual Field Loss ◽  
Optic Disc Drusen

Bilateral optic disc drusen with severe progressive visual field defect

2001 ◽  
Vol 25 (4) ◽  
pp. 229-232
Author(s):  
Tomoaki Usui ◽  
Mineo Takagi ◽  
Shigeru Hasegawa ◽  
Haruki Abe ◽  
Katsuhiko Nanba ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Visual Field Defect ◽  
Optic Disc Drusen ◽  
Field Defect

scholarly journals Different IOP, different diseases?

2016 ◽  
Vol 1 (2) ◽  
pp. 97-102
Author(s):  
Michele Iester ◽  
Elisa D’Alessandro
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Visual Field ◽  
Optic Disc ◽  
Progressive Disease ◽  
Clinical Findings ◽  
Nerve Fibers ◽  
Visual Field Defects ◽  
Chronic Progressive Disease ◽  
Field Defects

Glaucoma is a chronic, progressive disease characterized by typical optic nerve head changes and visual field defects. These alterations are caused by an intraocular pressure (IOP) being too high for the wellbeing of the specific optic disc. Typical clinical findings in glaucoma patients include thinning of the optic disc rim (Fig. 1), loss of retinal nerve fibers in the inferior sector with subsequent visual field defects in the superior sector.

Optic nerve appearance as a predictor of visual outcome in patients with idiopathic intracranial hypertension

2018 ◽  
Vol 103 (10) ◽  
pp. 1429-1435 ◽  
Author(s):  
Jonathan A Micieli ◽  
Beau B Bruce ◽  
Caroline Vasseneix ◽  
Richard J Blanch ◽  
Damian E Berezovsky ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Visual Field ◽  
Intracranial Hypertension ◽  
Optic Disc ◽  
Visual Function ◽  
Idiopathic Intracranial Hypertension ◽  
Visual Outcome ◽  
Mean Deviation ◽  
Cotton Wool Spots

Background/aimsIt remains unclear whether the presence of optic disc haemorrhages (ODH) or cotton wool spots (CWS) at presentation in patients with papilloedema from idiopathic intracranial hypertension (IIH) has prognostic value. The aim of this study was to determine if optic disc appearance at presentation predicts visual outcome in patients with IIH.MethodsRetrospective study of 708 eyes of 360 consecutive patients with IIH who had baseline optic disc photographs before or within 30 days of their diagnostic lumbar puncture and initiation of medical treatment. Optic disc photographs were independently graded by three ophthalmologists in a standardised manner. Visual function was assessed using Snellen converted to logMAR visual acuity, Humphrey mean deviation and visual field grade.ResultsAt least one ODH was found in 201 (28.4%) eyes, at least one CWS was found in 101 (14.3%) eyes and 88 eyes had both ODH and CWS (12.4%). At presentation, Frisén grade was associated with the presence and severity of ODH and CWS (p<0.001). ODH were associated with a worse visual acuity and CWS were associated with a worse visual field grade and mean deviation at presentation (p<0.05). Frisén grade was associated with worse visual function at presentation and final follow-up (p<0.001). Neither ODH nor CWS at presentation were associated with visual function at final follow-up when controlling for the Frisén grade.Conclusions and relevanceODH and CWS at baseline are not independent predictors of final visual function in IIH when controlling for the severity of papilloedema.

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