Optic Disc Drusen in Tilted Disc

2005 ◽  
Vol 15 (5) ◽  
pp. 647-651 ◽  
Author(s):  
G. Giuffrè
Keyword(s):  
Congenital Anomaly ◽  
Risk Factor ◽  
Optic Nerve ◽  
Optic Disc ◽  
Lamina Cribrosa ◽  
Nerve Fibers ◽  
Optic Disc Drusen ◽  
Fundus Photographs ◽  
Tilted Disc ◽  
Optic Nerve Drusen

Purpose To investigate if a congenital anomaly of the head of the optic nerve like such as tilted disc can be a risk factor for the development of optic disc drusen. Methods The study was performed retrospectively on the files of 47 patients with optic disc drusen. The diagnosis was confirmed by fluorescein angiography and B-scan ultrasonography. The authors examined the fundus photographs and the fluorescein angiographies of these patients looking for the presence of tilted discs. Results Two of the 47 patients with optic nerve drusen had tilted discs as well, about twice the expected rate. Both cases presented a parapapillary hemorrhage. Conclusions The concomitant presence of tilted disc and optic disc drusen can have a cause-effect relationship. The axonal crowding in a scleral canal of reduced size, as seen in tilted disc, can compress the nerve fibers against the stiff lamina cribrosa, producing a chronic optic neuropathy leading to drusen.

scholarly journals Topographic Quadrant Analysis of Peripapillary Superficial Microvasculature in Optic Disc Drusen

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Yan ◽  
Xiao Zhou ◽  
Zhongdi Chu ◽  
Laurel Stell ◽  
Mohammad Ali Shariati ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Function Analysis ◽  
Nerve Fibers ◽  
Quadrant Analysis ◽  
Mean Deviation ◽  
Structure Comparison ◽  
Parallel Change ◽  
Optic Disc Drusen ◽  
Temporal Quadrant

Background: Limited information is known about the topographic effect of optic disc drusen (ODD) on peripapillary retinal nerve fibers and microvasculature.Objective: This study aims to understand the structural and functional impact of ODD in different quadrants of the optic disc.Methods: We performed a retrospective case-control study of 22 ODD patients (34 eyes) and 26 controls (33 eyes) to compare optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), OCT angiography (OCTA), and corresponding static perimetry mean deviation (MD) calculated using the modified Garway-Heath map in different quadrants of the optic disc. OCTA was analyzed using custom MATLAB script to measure six parameters in a peripapillary annulus with large vessel removal: vessel area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI), vessel complexity index (VCI), flux, and vessel diameter index (VDI).Results: Quadrant analysis revealed that OCTA VAD and VCI were significantly decreased in superior, nasal, and inferior but not temporal quadrant. RNFL, VSD, and VPI were significantly impacted only in the superior and nasal quadrants. Corresponding visual field MDs in all ODD eyes were not different in the four quadrants, although eyes with MD equal or worse than −5 dB (32%) had worst visual field corresponding to the superior quadrant of the optic disc (inferior arcuate visual field). Structure-structure comparison of OCT and OCTA showed high correlation of RNFL with multiple OCTA measurements in the superior, nasal, and inferior quadrants but not temporal quadrant. Structure-function analysis revealed significant correlation of VAD and VCI and visual field MD in every quadrant, but RNFL was only significantly correlated in the superior and inferior quadrants.Conclusions: Peripapillary VAD and VCI are decreased in more quadrants than RNFL, supporting the clinical utility of performing OCTA in addition to OCT. Consistent with the most common locations of ODD, five OCT/OCTA measurements (VAD, VCI, RNFL, VSD, VPI) are decreased in the superior and nasal quadrants. OCT/OCTA measurements were significantly impacted in contrast to the relatively mild effect on corresponding visual field MD, consistent with the idea that a decrease in objective structural and vascular measurements occurs without parallel change in subjective visual function in ODD.

scholarly journals Retinal hemorrhages as one of complications of optic disc drusen during pregnancy

2014 ◽  
Vol 67 (5-6) ◽  
pp. 185-189
Author(s):  
Marija Trenkic-Bozinovic ◽  
Predrag Jovanovic ◽  
Gordana Zlatanovic ◽  
Dragan Veselinovic ◽  
Aleksandra Aracki-Trenkic ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Visual Field ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Ganglion Cells ◽  
Therapeutic Interventions ◽  
Visual Field Defects ◽  
Retinal Hemorrhages ◽  
Optic Disc Drusen

Introduction. Drusen of the optic nerve head are relatively benign and asymptomatic. They represent retinal hyaline corpuscles resulting from impaired axoplasmic transport of the retinal ganglion cells of optic nerve in front of the lamina cribrosa. They are usually detected accidentally, during a routine ophthalmologic examination. Most patients with optic disc drusen are not aware of the deterioration of their eyesight because of the slow progression of visual field defects. Damage in visual acuity due to optic disc drusen is rare. Case Report. A 27-year-old female patient in the sixth month of pregnancy visited an ophthalmologist because of a visual impairment described as the appearance of mist and shadows over her right eye. When first examined, her visual acuity in both eyes was 20/20. The retinal hemorrhages framing the bottom half of the optic nerve were seen. Complete laboratory and clinical testing as well as specific ophthalmic examinations (photofundus, computerized visual field, optical coherence tomography, and ultrasound) were performed to exclude systemic causes and they presented no risk for the pregnancy. Echosonographic examination confirmed the presence of bilateral optic nerve head drusen. Conclusion. Hemodynamic changes during pregnancy are possible factors for the development of optical disc and retinal hemorrhages. Since treatment of optic disc drusen is limited, recognition of optic nerve drusen as a cause of hemorrhage during pregnancy prevents unnecessary diagnostic and therapeutic interventions.

scholarly journals Optic disc drusen presenting as papilledema: a case report

2014 ◽  
Vol 4 (1) ◽  
pp. 42-44
Author(s):  
S Sitaula ◽  
M Thapa ◽  
AK Sharma
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Clinical Suspicion ◽  
Fundus Examination ◽  
Disc Edema ◽  
Medical College ◽  
Optic Disc Drusen ◽  
High Index Of Suspicion

Optic disc drusens, which are congenital anomalies of optic nerve head, are depositions of mucopolysaccharides and pro­teinaceous material within the optic nerve head. They are usually bilateral and diagnosed incidentally during routine fundus examination where they may be mistaken for papilledema. We report a case of 63 year old female referred to the neuro-ophthalmology department with the clinical suspicion of disc edema. Simple noninvasive investigations like ultrasound B-scan, fundus autofluorescene along with the newer test like spectral domain optical coherence tomography helped us to diagnose it as a case of pseudopapilledema, as optic disc drusen. Thus, a high index of suspicion along with the ancillary tests is helpful in differentiating optic disc drusen from true papilledema. DOI: http://dx.doi.org/10.3126/jcmc.v4i1.10848 Journal of Chitwan Medical College 2014; 4(1): 42-44

scholarly journals Different IOP, different diseases?

2016 ◽  
Vol 1 (2) ◽  
pp. 97-102
Author(s):  
Michele Iester ◽  
Elisa D’Alessandro
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Visual Field ◽  
Optic Disc ◽  
Progressive Disease ◽  
Clinical Findings ◽  
Nerve Fibers ◽  
Visual Field Defects ◽  
Chronic Progressive Disease ◽  
Field Defects

Glaucoma is a chronic, progressive disease characterized by typical optic nerve head changes and visual field defects. These alterations are caused by an intraocular pressure (IOP) being too high for the wellbeing of the specific optic disc. Typical clinical findings in glaucoma patients include thinning of the optic disc rim (Fig. 1), loss of retinal nerve fibers in the inferior sector with subsequent visual field defects in the superior sector.

scholarly journals The Angioarchitecture of the Optic Nerve Head in Patients with Optic Disc Drusen

2019 ◽  
Vol 44 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Julie Vahlgren ◽  
Lasse Malmqvist ◽  
Lea Lybæk Rueløkke ◽  
Isabelle Karlesand ◽  
Anne-Sofie Wessel Lindberg ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Optic Disc Drusen

scholarly journals OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 584
Author(s):  
Elisabeth Arnberg Wibroe ◽  
Lasse Malmqvist ◽  
Steffen Hamann
Keyword(s):  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Idiopathic Intracranial Hypertension ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Optic Disc Drusen

We aimed to systematically examine the optic nerve head anatomy in patients with idiopathic intracranial hypertension (IIH) using a standardized optical coherence tomography (OCT) protocol. The study retrospectively included 32 patients diagnosed from 2014 to 2021 with IIH. Using OCT, in accordance with a standardized scanning protocol for patients with optic disc drusen, the presence of optic disc drusen, prelaminar hyperreflective lines, peripapillary hyperreflective ovoid mass-like structures, the retinal nerve fiber layer thickness, and macular ganglion cell layer volume was obtained. Optic disc drusen were found in 3.1%, hyperreflective lines in 31.3%, and peripapillary hyperreflective ovoid mass-like structures in 81.3% of all IIH patients at least three months after the time of diagnosis. We found no significant differences in retinal nerve fiber layer thickness or macular ganglion cell layer volume in patients with hyperreflective lines or PHOMS respectively compared to patients without hyperreflective lines (p = 0.1285 and p = 0.1835). In conclusion, the prevalence of optic disc drusen in IIH patients is similar to the reported prevalence in the general population. The high prevalence of hyperreflective lines and peripapillary hyperreflective ovoid mass-like structures in IIH patients suggest these structures be a result of crowding in the optic nerve head caused by papilledema.

scholarly journals Choroidal Neovascularization in Congenital Disorders of the Optic Nerve

2007 ◽  
pp. 303-307
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Choroidal Neovascularization ◽  
Young Age ◽  
Age Related Macular Degeneration ◽  
Age Group ◽  
Important Place ◽  
Optic Nerve Diseases ◽  
Age Related ◽  
Optic Disc Drusen

Choroidal neovascularization is one of the most important visual losses seen in developed countries and is usually associated with age-related macular degeneration in the older age group. Choroidal neovascular membranes seen at a young age may be associated with pathologic myopia and ocular histoplasmosis; the idiopathic group also has an important place. Congenital optic nerve diseases are an important but rare disease group that makes peripapillary choroidal neovascularization in the young age group. Under these headings, besides isolated congenital optic nerve anomalies such as tilted disc, optic disc drusen, optic pit, and myelinated nerve fiber; anomalies showing serious neurological deficits such as optic disc coloboma, morning glory anomaly, optic nerve hypoplasia can also be counted. In this review, pathophysiology and treatment of the togetherness of optic nerve diseases and the neovascular membrane will be evaluated.

Optic Disc Drusen Associated with Optic Nerve Tumors

2015 ◽  
Vol 92 ◽  
pp. S67-S75 ◽  
Author(s):  
Kyoung Min Lee ◽  
Jeong-Min Hwang ◽  
Se Joon Woo
Keyword(s):  
Optic Nerve ◽  
Optic Disc ◽  
Optic Disc Drusen ◽  
Optic Nerve Tumors
Sign in / Sign up

Export Citation Format

Share Document