scholarly journals Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing

2021 ◽  
Vol 12 ◽  
Author(s):  
Jason Michael Johnson ◽  
Melissa M. Chen ◽  
Eric M. Rohren ◽  
Sujit Prabhu ◽  
Beth Chasen ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Conventional Imaging ◽  
Delayed Imaging ◽  
Time Points ◽  
Non Invasive ◽  
Imaging Time ◽  
Standardized Uptake Values ◽  
Pre Treatment ◽  
True Progression ◽  
Time Point

Background: Glioblastomas are malignant, often incurable brain tumors. Reliable discrimination between recurrent disease and treatment changes is a significant challenge. Prior work has suggested glioblastoma FDG PET conspicuity is improved at delayed time points vs. conventional imaging times. This study aimed to determine the ideal FDG imaging time point in a population of untreated glioblastomas in preparation for future trials involving the non-invasive assessment of true progression vs. pseudoprogression in glioblastoma.Methods: Sixteen pre-treatment adults with suspected glioblastoma received FDG PET at 1, 5, and 8 h post-FDG injection within the 3 days prior to surgery. Maximum standard uptake values were measured at each timepoint for the central enhancing component of the lesion and the contralateral normal-appearing brain.Results: Sixteen patients (nine male) had pathology confirmed IDH-wildtype, glioblastoma. Our results revealed statistically significant improvements in the maximum standardized uptake values and subjective conspicuity of glioblastomas at later time points compared to the conventional (1 h time point). The tumor to background ratio at 1, 5, and 8 h was 1.4 ± 0.4, 1.8 ± 0.5, and 2.1 ± 0.6, respectively. This was statistically significant for the 5 h time point over the 1 h time point (p > 0.001), the 8 h time point over the 1 h time point (p = 0.026), and the 8 h time point over the 5 h time point (p = 0.036).Conclusions: Our findings demonstrate that delayed imaging time point provides superior conspicuity of glioblastoma compared to conventional imaging. Further research based on these results may translate into improvements in the determination of true progression from pseudoprogression.

scholarly journals PC3 - 219 Evaluation of delayed FDG-PET in differentiating progressive disease from post-treatment radiation effect in brain tumors

2016 ◽  
Vol 43 (S4) ◽  
pp. S23-S23
Author(s):  
R.A. Harrison ◽  
A. Masood ◽  
O. Mawlawi ◽  
D. Schellingerhout ◽  
B.A. Chasen ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Fdg Pet ◽  
Progressive Disease ◽  
Radiation Effect ◽  
Post Treatment ◽  
Delayed Imaging ◽  
Time Points ◽  
Delayed Time ◽  
Time Point

Traditional and advanced magnetic resonance imaging techniques are often unable to differentiate progressive central nervous system neoplasm from post-treatment radiation effect (PTRE). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) with delayed imaging has been shown to increase the specificity of PET imaging for cerebral neoplasm in small studies. We sought to further evaluate the potential diagnostic benefits of delayed imaging at 5 hours versus standard imaging at 1 hour to differentiate progressive disease (PD) from PTRE in patients with primary or metastatic brain tumors treated with radiation therapy.Ten patients with primary (n=4) and metastatic (n=6) brain tumors were identified, with diagnostic confirmation of PD or PTRE provided by pathology or>3 month clinical and radiographic follow-up. Maximum standard uptake values (SUV) were calculated for suspicious areas of abnormal contrast enhancement (lesion) and compared to contralateral normal appearing brain (background) at both early and delayed time points. Seven patients were classified as having PD and 3 as having PTRE based pathology or clinical/radiographic follow up. The average lesion to background ratio (L/B) at the early time point (1.16+0.50) was significantly different than L/B for the later time point (1.72+1.10), p=0.030. The mean L/B for PD was 2.17+1.01 at the later time point compared to 0.65+0.06 for PTRE (p=0.010). For the earlier time point, L/B for PD was 1.40+0.42, compared to the L/B for PTRE which was 0.61+0.10 (p=0.003).L/B ratios at early and delayed time points successfully differentiated between patients with PD and PTRE, with significantly greater L/B ratios seen at delayed time points. These initial results are promising and further investigation is underway to evaluate the contribution of delayed imaging in differentiating PD from PTRE.

scholarly journals L-Alanyl-Glutamine dipeptide pretreatment attenuates ischemia-reperfusion injury in rat testis

2011 ◽  
Vol 26 (suppl 1) ◽  
pp. 21-25 ◽  
Author(s):  
João Paulo de Vasconcelos Leitão ◽  
Jefferson Menezes Viana Santos ◽  
Raquel Cavalcante de Vasconcelos ◽  
José Huygens Parente Garcia ◽  
Paulo Roberto Leitão de Vasconcelos ◽  
...  
Keyword(s):  
Spermatic Cord ◽  
Testicular Torsion ◽  
Ischemia Reperfusion Injury ◽  
Reduced Glutathione ◽  
Ischemia Reperfusion ◽  
Time Points ◽  
Rat Testis ◽  
Pre Treatment ◽  
The Right ◽  
Time Point

PURPOSE: To investigate the effect of alanyl-glutamine dipeptide (L-Ala-Gln) pre-treatment on ischemia-reperfusion (I/R) injury after unilateral testicular torsion-detorsion in a comparative controlled experiment. METHODS: Forty-eight rats (150-200 g) randomly distributed into 4 groups (n=12), and distributed in 2 subgroups (n=6) each, were treated with saline 2.0 ml (G-1, G-3) or L-Ala-Gln 20%, 0.75g/kg dissolved in saline (total volume 2.0 ml) administered in the left saphenous vein 30 minutes before ischemia. Anesthetized rats were subjected to I/R induced by torsion (720°) of the right spermatic cord lasting 1h (G-1, G-2) or 3 hours (G-3, G4). Anesthesia was again applied at the end of ischemia time (T-0) for testis detorsion and 6 hours later (T-6) for orchiectomy. All operations were performed on the right testes through transverse scrotal incisions. Right orchiectomy was carried out at the end of ischemia (T-0), and 6 hours later (T-6) to evaluate the concentrations of malondialdehyde (MDA) and reduced glutathione (GSH) in the testis. RESULTS: Pretreatment with L-Ala-Gln reduced MDA contents in rat testis at the end of ischemia lasting 3 hours. There was significant increase of GSH levels in T-6 time-point after 1 hour of ischemia. GSH levels also increased in T-0 and T-6 time-points in rats subjected to ischemia for 3 hours. CONCLUSION: L-Ala-Gln administered before torsion/detorsion of the spermatic cord decreases lipid peroxidation during ischemia and protects the testis from oxidative stress by upregulating GSH levels during reperfusion.

Inhibition and flare patterns of metabolic response to the heat shock protein 90 (Hsp90) inhibitor IPI-504 visualized by FDG-PET in patients (pts) with advanced gastrointestinal stromal tumors (GIST) resistant to tyrosine kinase inhibitor (TKI) therapy

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 3530-3530 ◽  
Author(s):  
A. D. Van den Abbeele ◽  
J. T. Yap ◽  
D. S. Grayzel ◽  
J. Walker ◽  
G. D. Demetri
Keyword(s):  
Fdg Pet ◽  
Kinase Inhibitor ◽  
Metabolic Response ◽  
Clinical Investigation ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibitor ◽  
Resistance Mutations ◽  
Hsp90 Inhibition ◽  
Standardized Uptake Values ◽  
Time Point

3530 Background: We have previously demonstrated the inhibition and rebound of GIST glycolytic metabolism with FDG-PET while pts were on or off TKI in prior trials of imatinib and sunitinib. We tested the same principle in a phase I trial of IPI-504, a novel potent inhibitor of Hsp90 (a chaperone for protein homeostasis) that results in selective destruction of the mutated KIT kinase in human GIST cell lines regardless of TKI-resistance mutations. Methods: Twenty-one patients with metatastic and/or unresectable GIST following failure of prior therapy with TKI were treated with IPI-504. Serial FDG-PET imaging was performed at baseline, during the 1st cycle after at least 2 doses (C1, days 4–11, “ON”, n = 18), and at the end of the 10-day off-treatment period prior to the start of the 2nd cycle (C1, “OFF”, n = 20). A subset of 5 pts also had FDG-PET at the end of the 3rd cycle (C3, day 11, “ON”). Maximum standardized uptake values (SUVmax) were measured in up to 3 lesions/pt with the greatest FDG uptake, and the SUVmax of all lesions was summed at each time point. Percent change in the summed mean SUVmax was calculated at each time point relative to the previous scan. Temporal changes were evaluated in those pts showing more than a 10% decrease in SUVmax during C1 “ON” compared to baseline. Results: We observed a >10% reduction in SUVmax (mean = - 28%) during the 1st cycle (C1, “ON”) in 8/18 pts. All these pts showed an increase in SUVmax (mean = +29%) when off therapy (C1, “OFF”). Three of these 8 pts had a scan during cycle 3. All demonstrated a decrease in SUVmax (mean = -30%) while on the drug (C3, “ON”). Conclusion: These preliminary findings suggest that: (1) tumor metabolic response as measured with FDG-PET parallels the intermittent pattern of IPI-504 administration in this study as early as after the 2nd dose administration; and, (2) IPI-504 has a rapid downstream effect on glucose metabolism similar to that observed with TKIs despite the very different mechanism of action of IPI-504. The pattern of response to Hsp90 inhibition seen in this heavily pretreated population strongly supports further clinical investigation. No significant financial relationships to disclose.

Diagnostic value of F-18 FDG PET/CT in patients with spondylodiscitis: Is dual time point imaging time worthy?

2016 ◽  
Vol 85 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Burcak Yilmaz Gunes ◽  
Cetin Onsel ◽  
Kerim Sonmezoglu ◽  
Resat Ozaras ◽  
Metin Halac ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Diagnostic Value ◽  
Imaging Time ◽  
Pet Ct ◽  
Dual Time Point ◽  
Fdg Pet Ct ◽  
Time Point

scholarly journals Added Value of Dual-Time-Point 18F-FDG PET/CT With Delayed Imaging for Detecting Aortic Graft Infection

Medicine ◽  
2015 ◽  
Vol 94 (27) ◽  
pp. e1124 ◽  
Author(s):  
Chih-Yung Chang ◽  
Cheng-Pei Chang ◽  
Chun-Che Shih ◽  
Bang-Hung Yang ◽  
Cheng-Yi Cheng ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Graft Infection ◽  
Added Value ◽  
Aortic Graft ◽  
Delayed Imaging ◽  
Pet Ct ◽  
Aortic Graft Infection ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Time Point

scholarly journals Time Sensitivity Factor of Single Pulmonary Nodule: A New Cancer Characteristic Metabolic Parameter byF18-FDG PET

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ching-Yuan Cheng ◽  
Kwo-Whei Lee ◽  
Chiang-Hsuan Lee ◽  
Yeu-Sheng Tyan ◽  
Cheng-Yi Cheng ◽  
...  
Keyword(s):  
Pulmonary Nodule ◽  
Fdg Pet ◽  
Metabolic Parameter ◽  
Sensitivity Factor ◽  
Multiple Time ◽  
Time Intervals ◽  
Time Points ◽  
Multiple Time Point ◽  
Time Sensitivity ◽  
Time Point

Objective. To calculate the time sensitivity factor (S) for discriminating the solitary pulmonary nodule (SPN) by FDG PET at different time points.Methods. The multiple time-point FDG PET images from 41 patients for evaluating SPN seen on chest X-ray or CT were prospectively analyzed to calculate and evaluateSagainst the gold standard of tissue histology (n=38) or long term clinicoradiographic follow-up (n=3). The maximal standardized uptake values (SUV) at the 3 hourly time points were measured. TheSwas calculated usingS=d{ln⁡(SUV)}/d{ln⁡(t)}at 3 different time intervals. ROC analysis of theSparameters was performed to evaluate the optimal cut-off value and their accuracy in classifying the SPN.Results. The SUV in malignant SPN was higher than the corresponding value in benign lesions at all 3 hourly time points (P<0.003). TheSparameters using 3 different time intervals all significantly separated the two groups (P<0.0005) with an optimal cut-off point near the theoretical value of zero with a high sensitivity of 100% and specificity of 86%.Conclusion. TheScan be calculated for SPNs using multiple time-point FDG PET, providing a tumor characteristic metabolic parameter with high discrimination power using a simple positive value representing malignancy.

scholarly journals Long-Term Monitoring of Dynamic Changes in Plasma EBV DNA For Improved Prognosis Prediction of Nasopharyngeal Carcinoma

2020 ◽  
Author(s):  
Wanxia Li ◽  
Jing Chen ◽  
Bijun Liang ◽  
Zonghua Li ◽  
Junzheng Li ◽  
...  
Keyword(s):  
Dynamic Change ◽  
Post Treatment ◽  
Dynamic Changes ◽  
Free Survival ◽  
Time Points ◽  
Ebv Dna ◽  
Pre Treatment ◽  
Negative Detection ◽  
Time Point

Abstract Background: This study was performed to investigate whether long-term monitoring of dynamic changes in plasma Epstein-Barr virus (EBV) DNA could improve prognosis prediction of nasopharyngeal carcinoma (NPC).Methods: 1077 non-metastatic NPC patients were recruited to retrospectively analyze the prognostic value of plasma EBV DNA load pre-treatment and 3, 12, 24, and 36 months post-treatment. We also examined the prognostic value of dynamic changes in plasma EBV DNA at various time points.Results: Patients with plasma EBV DNA load above optimal pre- and post-treatment cut-offs had significantly worse five-year progression-free survival, distant metastasis-free survival, locoregional relapse-free survival, and overall survival(OS) at all time points, excluding only OS at 36 months post-treatment due to limited mortalities. Patients with persistently undetectable plasma EBV DNA at the first four time points had the best prognosis, followed by those with positive detection pre-treatment and consistently negative detection post-treatment, those with negative detection pre-treatment and positive detection at one time point post-treatment, and those with positive detection pre-treatment and at one time point post-treatment, whereas patients with positive detection at ≥2 time points post-treatment had the worst prognosis. Cox proportional hazard models identified the dynamic change pattern as an independent prognostic factor, and ROC curve analysis demonstrated that the dynamic change at four time point was more valuable than any single time point for predicting disease progression, distant metastasis, locoregional relapse, and mortality.Conclusions: Dynamic changes in plasma EBV DNA pre- and post-treatment could predict the long-term survival outcome and provide accurate risk stratification in NPC.

Influence of scan time point and volume of intravenous contrast administration on blood-pool and liver SUVmax and SUVmean in [18F] FDG PET/CT

2018 ◽  
Vol 57 (02) ◽  
pp. 50-55
Author(s):  
Timm Braun ◽  
Panagiota Manava ◽  
Sigrid Ludwigs ◽  
Michael Lell ◽  
Matthias Schoen
Keyword(s):  
Fdg Pet ◽  
Contrast Material ◽  
Blood Pool ◽  
Intravenous Contrast ◽  
Scan Time ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Time Point

Summary Aim: To investigate the influence of scan time point and volume of intravenous contrast material in 18F-FDG PET/CT on maximum and mean standardized uptake values (SUVmax/mean) in bloodpool and liver. Methods: In 120 patients scheduled for routine whole-body 18F-FDG PET/CT the maximum and mean standardized uptake values (SUVmax/SUVmean) in the liver and blood pool were measured after varying scan time-point (delay 0 s-140 s post injectionem) and volume of contrast material (CM; 0 ml, 80 ml, 100 ml of 300 mg/ml of Iodine). Six groups of 20 patients were investigated: (1) without intravenous CM, (2-5) injection of 100 ml CM with a delay of 80 s (2), 100 s (3), 120 s (4), 140 s (5), and 80 ml CM and a delay of 100 s (6). SUVmax, SUVmean, maximum Hounsfield units (HUmax) and average Hounsfield units (HUav) were calculated with the use of manually drawn regions of interests (ROIs) over the aortic arch and healthy liver tissue. Results: SUVmax in bloodpool was significantly higher in group 3, 4 and 6 compared to group 1. Groups 2 and 5 also showed higher mean values of SUVmax, but the difference was not significant. SUVmean in bloodpool was also higher in groups 2, 3, 4, 5 and 6 compared to group 1, but the differences were only statistically significant in group 3. Both SUVmax and SUVmean in healthy liver tissue did not show significant differences when compared to the non contrast-enhanced control group. Conclusion: SUVmax and to a lesser extent SUVmean measured in CM enhanced FDG PET/CT in blood pool could be significantly altered in high contrast CT examinations. This should be kept in mind in PET/CT protocols and evaluation relying on SUVmax and SUVmean, for example when used in the assessment of therapy response, especially in highly vascularized tumor lesions.

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