scholarly journals A Response to: Commentary: Stabilizing Constructs through Collaboration across Different Research Fields as a Way to Foster the Integrative Approach of the Research Domain Criteria (RDoC) Project

2016 ◽  
Vol 10 ◽  
Author(s):  
Jacqueline A. Sullivan
Keyword(s):  
Integrative Approach ◽  
Research Domain Criteria ◽  
Research Fields ◽  
Research Domain

scholarly journals Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior

2012 ◽  
Vol 14 (1) ◽  
pp. 29-37 ◽  
Keyword(s):  
Mental Disorders ◽  
Neural Circuits ◽  
Integrative Approach ◽  
Research Domain Criteria ◽  
Diagnostic Systems ◽  
Research Perspective ◽  
Treatment And Prevention ◽  
Regulatory Systems ◽  
Positive Valence ◽  
Research Domain

Current diagnostic systems for mental disorders were established before the tools of neuroscience were available, and although they have improved the reliability of psychiatric classification, progress toward the discovery of disease etiologies and novel approaches to treatment and prevention may benefit from alternative conceptualizations of mental disorders. The Research Domain Criteria (RDoC) initiative is the centerpiece of NIMH's effort to achieve its strategic goal of developing new methods to classify mental disorders for research purposes. The RDoC matrix provides a research framework that encourages investigators to reorient their research perspective by taking a dimensional approach to the study of the genetic, neural, and behavioral features of mental disorders, RDoCs integrative approach includes cognition along with social processes, arousal/regulatory systems, and negative and positive valence systems as the major domains, because these neurobehavioral systems have all evolved to serve the motivational and adaptive needs of the organism. With its focus on neural circuits informed by the growing evidence of the neurodevelopmental nature of many disorders and its capacity to capture the patterns of co-occurrence of behaviors and symptoms, the RDoC approach holds promise to advance our understanding of the nature of mental disorders.

Challenges of Fear Conditioning Research in the Age of RDoC

2017 ◽  
Vol 225 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Tina B. Lonsdorf ◽  
Jan Richter
Keyword(s):  
Fear Conditioning ◽  
Clinical Diagnosis ◽  
Research Domain Criteria ◽  
Major Focus ◽  
The Future ◽  
Definition Of ◽  
Methodological Considerations ◽  
Research Domain

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.

The Psychophysiology of Anxiety and Mood Disorders

2017 ◽  
Vol 225 (3) ◽  
pp. 175-188 ◽  
Author(s):  
Peter J. Lang ◽  
Lisa M. McTeague ◽  
Margaret M. Bradley
Keyword(s):  
Mental Health ◽  
Heart Rate ◽  
Brain Function ◽  
Physiological Reactivity ◽  
Research Domain Criteria ◽  
Diagnostic Systems ◽  
Psychophysiological Reactivity ◽  
Diagnostic Categories ◽  
New Research ◽  
Research Domain

Abstract. Several decades of research are reviewed, assessing patterns of psychophysiological reactivity in anxiety patients responding to a fear/threat imagery challenge. Findings show substantive differences in these measures within principal diagnostic categories, questioning the reliability and categorical specificity of current diagnostic systems. Following a new research framework (US National Institute of Mental Health [NIMH], Research Domain Criteria [RDoC]; Cuthbert & Insel, 2013 ), dimensional patterns of physiological reactivity are explored in a large sample of anxiety and mood disorder patients. Patients’ responses (e.g., startle reflex, heart rate) during fear/threat imagery varied significantly with higher questionnaire measured “negative affect,” stress history, and overall life dysfunction – bio-marking disorder groups, independent of Diagnostic and Statistical Manuals (DSM). The review concludes with a description of new research, currently underway, exploring brain function indices (structure activation, circuit connectivity) as potential biological classifiers (collectively with the reflex physiology) of anxiety and mood pathology.

The Starry Deer Caiman and Structure 44 at Yaxchilan, Chiapas, Mexico

2016 ◽  
Vol 2 (1) ◽  
pp. 5-24 ◽  
Author(s):  
Stanislaw Iwaniszewski ◽  
Jesús Galindo Trejo
Keyword(s):  
Milky Way ◽  
Integrative Approach ◽  
Research Fields ◽  
Dwelling House ◽  
House Building

This paper analyses the meaning of astronomical alignments of Structure 44 from Yaxchilan, Mexico. The lack of direct solar referents calls for a more integrative approach in which archaeoastronomy is supplemented by the research fields of archaeology, epigraphy and iconography. The designation of Structure 44 as an otoot (dwelling, house) building allows us to conceptualize it as a type of animate entity which is linked with the representation of the figure of the Starry Deer Caiman, one of the Maya Milky Way constellations.

Trauma and mood disorders: comorbidity with post-traumatic stress disorder or overlapping symptoms?

2016 ◽  
Vol Ano 6 ◽  
pp. 38-42
Author(s):  
Andrea Feijó Mello ◽  
Euthymia B. Almeida Prado
Keyword(s):  
Mood Disorders ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Research Domain Criteria ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Research Domain

O presente artigo discorre sobre a comorbidade entre transtorno bipolar (TB) e transtorno de estresse póstraumático (TEPT) e questiona sobre certos casos serem melhor avaliados à luz das novas teorias do Research Domain Criteria (RDoC), principalmente aqueles quadros de TEPT com sintomas disfóricos que podem ser classificados como TB, apesar de não preencherem critérios para tal. Nesse caso, questiona-se a comorbidade e propõe-se um aprofundamento da fisiopatologia dessa sintomatologia que está sobreposta. Clinicamente, esse olhar poderá facilitar o manejo farmacológico de pacientes graves com histórico de trauma.

Positive Mood States and Gambling Disorder

2019 ◽  
pp. 366-379
Author(s):  
Sarah W. Yip ◽  
Zu Wei Zhai ◽  
Iris M. Balodis ◽  
Marc N. Potenza
Keyword(s):  
Impulse Control ◽  
Gambling Disorder ◽  
Adult Population ◽  
Approach Motivation ◽  
Gambling Problems ◽  
Research Domain Criteria ◽  
Monetary Rewards ◽  
Neuroimaging Data ◽  
Positive Valence ◽  
Research Domain

Gambling problems are experienced by about 1% of the adult population, with higher estimates reported in adolescents. Both positive and negative motivations for gambling exist and may contribute to gambling problems. Positive valence disturbances involving how people process rewards, including monetary rewards relevant to gambling, have been reported in gambling disorder and have been associated with the disorder and clinically relevant measures relating to impaired impulse control. Positive valence systems as they relate to gambling disorder and clinically relevant features thereof are considered in this chapter. Findings from neuroimaging data related to the positive valence system constructs of approach motivation, initial and sustained/longer term responsiveness to reward, habit and reward learning are reviewed. Possible interactions between positive valence systems and other Research Domain Criteria (RDoC) systems are also discussed within the context of gambling disorder, as is how the application of an RDoC framework can be used to further understanding of gambling disorder.

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