scholarly journals Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation

2017 ◽  
Vol 11 ◽  
Author(s):  
Xiangsheng Zhang ◽  
Qi Wu ◽  
Qingrong Zhang ◽  
Yue Lu ◽  
Jingpeng Liu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Nlrp3 Inflammasome ◽  
Early Brain Injury ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Experimental Subarachnoid Hemorrhage

scholarly journals COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Yongfa Zhang ◽  
Baocheng Gao ◽  
Jingsong Ouyang ◽  
Bai Tai ◽  
Shuai Zhou
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Early Brain Injury ◽  
Brain Barrier ◽  
Inflammasome Activation ◽  
Mimetic Peptide ◽  
Blood Brain ◽  
Experimental Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a kind of severe hemorrhagic stroke, and early brain injury acted as one of the main causes of death and delayed neurological deficit in patients with subarachnoid hemorrhage. In this process, the function and structural integrity of the blood-brain barrier play an important role. In this study, we have observed whether the apolipoprotein E (apoE) mimetic peptide, COG133, can alleviate early brain injury after subarachnoid hemorrhage. For this purpose, an experimental subarachnoid hemorrhage model was constructed in mice and treated by intravenous injection of COG133 at a dosage of 1 mg/kg. Then, the function and integrity of the blood-brain barrier were detected, and the pyroptosis level of the neuron was determined. The results showed that COG133 could protect blood-brain barrier function and structure integrity, reduce early brain injury, and ameliorate neurological function after subarachnoid hemorrhage. In terms of molecular mechanism, COG133 inhibits blood-brain barrier destruction through the proinflammatory CypA-NF-κB-MMP9 pathway and reduces neuronal pyroptosis by inhibiting NLRP3 inflammasome activation. In conclusion, this study demonstrated that apoE-mimetic peptide, COG133, can play a neuroprotective role by protecting blood-brain barrier function and inhibiting brain cell pyroptosis to reduce early brain injury after subarachnoid hemorrhage.

scholarly journals Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

2019 ◽  
Vol 152 (3) ◽  
pp. 368-380 ◽  
Author(s):  
Yuke Xie ◽  
Jianhua Peng ◽  
Jinwei Pang ◽  
Kecheng Guo ◽  
Lifang Zhang ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Microglial Activation ◽  
Early Brain Injury ◽  
Experimental Subarachnoid Hemorrhage

scholarly journals Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage

2015 ◽  
Vol 12 (1) ◽  
pp. 967-973 ◽  
Author(s):  
BINGJIE ZHENG ◽  
HUAILEI LIU ◽  
RUKE WANG ◽  
SHANCAI XU ◽  
YAOHUA LIU ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Early Brain Injury ◽  
Experimental Subarachnoid Hemorrhage ◽  
Non Coding Rnas

scholarly journals TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage

2015 ◽  
Vol 290 (32) ◽  
pp. 19900-19909 ◽  
Author(s):  
Dingding Zhang ◽  
Huiying Yan ◽  
Hua Li ◽  
Shuangying Hao ◽  
Zong Zhuang ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Early Brain Injury ◽  
Experimental Subarachnoid Hemorrhage
Sign in / Sign up

Export Citation Format

Share Document