scholarly journals Radiofrequency Ablation vs. Surgical Resection for Small Early-Stage Primary Intrahepatic Cholangiocarcinoma

2020 ◽  
Vol 10 ◽  
Author(s):  
Xin Xiang ◽  
Daixing Hu ◽  
Zheng Jin ◽  
Pan Liu ◽  
Huapeng Lin
Keyword(s):  
Radiofrequency Ablation ◽  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Early Stage

Surgical resection versus radiofrequency ablation very early‐stage HCC (≤2 cm Single HCC): A propensity score analysis

2019 ◽  
Vol 39 (12) ◽  
pp. 2397-2407 ◽  
Author(s):  
Hee Ho Chu ◽  
Jin Hyoung Kim ◽  
Pyo Nyun Kim ◽  
So Yeon Kim ◽  
Young‐Suk Lim ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Propensity Score ◽  
Surgical Resection ◽  
Propensity Score Analysis ◽  
Early Stage ◽  
Score Analysis

Radiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 379-379
Author(s):  
Abdulrahman Y Hammad ◽  
George Younan ◽  
Rahul Rajeev ◽  
Nicholas Gerard Berger ◽  
Kiran Turaga ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Resection Margin ◽  
Early Stage ◽  
Disease Stage ◽  
Resection Margins ◽  
National Cancer Database ◽  
Kaplan Meier ◽  
Positive Resection Margins ◽  
The Impact

379 Background: The role of radiotherapy (RT) for surgically resected intrahepatic cholangiocarcinoma (ICC) remains poorly defined. Radiotherapy is often considered when a positive resection margin exists. The present study sought to examine the impact of radiotherapy following liver resection. Methods: Patients with early stage ICC, who underwent surgical resection, were identified from the National Cancer Database (1998-2011). Patients were stratified by resection margin status and receipt of RT. Survival was analyzed by Kaplan-Meier method and a multivariate regression model was used to identify predictors of survival. Results: A total of 2,182 patients were identified. R0 status was obtained in 1,624 patients (74.4%). RT was delivered to 405 patients (R0=209, R1/R2=196). In the R1/R2 group, 196 patients received RT vs. 362 R1/R2 patients that did not receive RT. Survival for R0 vs. R1/R2 was 32m vs. 16.5m (p<0.001). RT appeared to trend toward improving survival for R1/R2 patients, though this was not significant (20.4m vs. 14.5m, p=0.191). In a multivariate model accounting for age, sex, comorbidities, disease stage and resection margins, RT was not a predictor of survival. Negative predictors of survival included age>65years (Hazards Ratio [HR]: 1.20 (95%CI: 1.04-1.39), p=0.013), and positive resection margins (HR: 1.95 (95%CI: 1.65-2.30), p<0.001). Female sex was the only positive predictor of survival identified (HR: 0.76 (95%CI: 0.65 -0.88), p<0.001). Conclusions: Surgical resection with negative margins provides the best outcome for patients with ICC. Radiotherapy does not appear to significantly impact survival in patients with positive resection margins.

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