scholarly journals Preclinical Models and Resources to Facilitate Basic Science Research on Malignant Mesothelioma – A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Ben William Johnson ◽  
Ken Takahashi ◽  
Yuen Yee Cheng
Keyword(s):  
Malignant Mesothelioma ◽  
Basic Science ◽  
Latency Period ◽  
Science Research ◽  
Developed Countries ◽  
Diagnosis And Treatment ◽  
Preclinical Models ◽  
Basic Science Research ◽  
Radio Therapy ◽  
Laboratory Technology

Malignant mesothelioma is an aggressive cancer with poor prognosis, predominantly caused by human occupational exposure to asbestos. The global incidence of mesothelioma is predicted to increase as a consequence of continued exposure to asbestos from a variety of sources, including construction material produced in the past in developed countries, as well as those currently being produced in developing countries. Mesothelioma typically develops after a long latency period and consequently it is often diagnosed in the clinic at an advanced stage, at which point standard care of treatment, such as chemo- and radio-therapy, are largely ineffective. Much of our current understanding of mesothelioma biology, particularly in relation to disease pathogenesis, diagnosis and treatment, can be attributed to decades of preclinical basic science research. Given the postulated rising incidence in mesothelioma cases and the limitations of current diagnostic and treatment options, continued preclinical research into mesothelioma is urgently needed. The ever-evolving landscape of preclinical models and laboratory technology available to researchers have made it possible to study human disease with greater precision and at an accelerated rate. In this review article we provide an overview of the various resources that can be exploited to facilitate an enhanced understanding of mesothelioma biology and their applications to research aimed to improve the diagnosis and treatment of mesothelioma. These resources include cell lines, animal models, mesothelioma-specific biobanks and modern laboratory techniques/technologies. Given that different preclinical models and laboratory technologies have varying limitations and applications, they must be selected carefully with respect to the intended objectives of the experiments. This review therefore aims to provide a comprehensive overview of the various preclinical models and technologies with respect to their advantages and limitations. Finally, we will detail about a highly valuable preclinical laboratory resource to curate high quality mesothelioma biospecimens for research; the biobank. Collectively, these resources are essential to the continued advancement of precision medicine to curtail the increasing health burden caused by malignant mesothelioma.

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

Setting Up for Success: Strategies to Foster Surgeons’ Pursuit of Basic Science Research

2021 ◽  
Vol 268 ◽  
pp. 71-78
Author(s):  
Devon Livingston-Rosanoff ◽  
Keon Young Park ◽  
Esra Alagoz ◽  
Susan Thibeault ◽  
Angela Gibson
Keyword(s):  
Basic Science ◽  
Science Research ◽  
Success Strategies ◽  
Basic Science Research

scholarly journals Research Productivity and Citation Impact of Indian institutes of Science Education and Research

2021 ◽  
Vol 41 (6) ◽  
pp. 455-462
Author(s):  
Jyotshna Sahoo ◽  
Sudam Charan Sahu ◽  
Basudev Mohanty
Keyword(s):  
Science Education ◽  
Research Productivity ◽  
Basic Science ◽  
Research Output ◽  
Citation Impact ◽  
Science Research ◽  
Publication Patterns ◽  
Research Outcomes ◽  
Basic Science Research ◽  
Research Publications

The paper’s main objective is to investigate the trends of basic science research in India using a combination of qualitative and quantitative approaches. It examines the publication patterns and impact of research productivity of five basic science institutions, i.e., “Indian Institutes of Science Education and Research” (IISER), namely IISER Kolkata, IISER Pune, IISER Mohali, IISER Bhopal, and IISER Thiruvananthapuram. The research output indexed in the SCOPUS bibliographic database of these five established IISERs was obtained from 2015 to 2019. A total number of 7329 research publications were analysed using various scientometric dimensions. This paper makes a concerted effort to present a comprehensive picture of the assessment of research outcomes at the five older IISERs, which are ostensibly India’s most active and prominent basic science research institutions. The findings reveal that these institutions are accountable for important research outcomes, such as a high number of citations, preferences towards open access (OA) publications, a rise in research publication year over year, a strong author network, a high degree of collaboration, and a high impact in terms of other scientometrics indicators. This paper discusses the findings of the research publications on the position of IISERs in basic sciences research and draws some conclusions about their effects.

scholarly journals Basic science research in medicine

2012 ◽  
Vol 8 (3) ◽  
pp. 292-293
Author(s):  
A S Pandey
Keyword(s):  
Basic Science ◽  
Science Research ◽  
Basic Science Research

No abstract availableDOI: http://dx.doi.org/10.3126/kumj.v8i3.6214 Kathmandu Univ Med J 2010;8(3):292-3 

Advances in Basic Science Research

2010 ◽  
pp. 72-77
Author(s):  
Derrick C. Wan ◽  
Matthew D. Kwan ◽  
Eric I-Yun Chang ◽  
Geoffrey C. Gurtner ◽  
Michael T. Longaker
Keyword(s):  
Basic Science ◽  
Science Research ◽  
Basic Science Research

Sustainability in Higher Education through Basic Science Research

2012 ◽  
pp. 56-66
Author(s):  
P. Yogeeswari ◽  
D. Sriram
Keyword(s):  
Higher Education ◽  
Basic Science ◽  
Basic Research ◽  
Science Research ◽  
Medical Sciences ◽  
Industrial Growth ◽  
Non Profit ◽  
Social Sciences And Humanities ◽  
Basic Science Research ◽  
Recent Developments

Basic research in Universities is essential for a sustainable development. Recent developments in higher education have seen the inclusion of curiculum redesigned to serve the concept of developming young minds in the intrepretation, execution, and use of basic science research. The challenge for educators is to “demystify” research and teach in ways that are professionally meaningful as well as intellectually acceptable. The objective of this chapter is to bring in various case studies to prove the essentiality of basic research in higher education with specific concern over pharmaceutical industrial growth plans. Data on R&D in higher education can be broken down by field of science (natural sciences, engineering, medical sciences, agricultural sciences, social sciences, and humanities), by type of costs (current expenditures, capital expenditures), and by source of funds (business enterprise, government, higher education, private non-profit, and funds from abroad). Measures of R&D performance in the higher education sector are often estimated by national authorities, and evaluation methods are periodically revised. It is necessary to review the design and conduct of higher education R&D surveys to improve the comparability of these indicators.

Sustainability in Higher Education through Basic Science Research

2015 ◽  
pp. 666-676
Author(s):  
P. Yogeeswari ◽  
D. Sriram
Keyword(s):  
Higher Education ◽  
Basic Science ◽  
Basic Research ◽  
Science Research ◽  
Medical Sciences ◽  
Industrial Growth ◽  
Non Profit ◽  
Social Sciences And Humanities ◽  
Basic Science Research ◽  
Recent Developments

Basic research in Universities is essential for a sustainable development. Recent developments in higher education have seen the inclusion of curiculum redesigned to serve the concept of developming young minds in the intrepretation, execution, and use of basic science research. The challenge for educators is to “demystify” research and teach in ways that are professionally meaningful as well as intellectually acceptable. The objective of this chapter is to bring in various case studies to prove the essentiality of basic research in higher education with specific concern over pharmaceutical industrial growth plans. Data on R&D in higher education can be broken down by field of science (natural sciences, engineering, medical sciences, agricultural sciences, social sciences, and humanities), by type of costs (current expenditures, capital expenditures), and by source of funds (business enterprise, government, higher education, private non-profit, and funds from abroad). Measures of R&D performance in the higher education sector are often estimated by national authorities, and evaluation methods are periodically revised. It is necessary to review the design and conduct of higher education R&D surveys to improve the comparability of these indicators.

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