scholarly journals Association of Maternal Gestational Weight Gain With Left Ventricle Geometry and Function in Offspring at 4 Years of Age: A Prospective Birth Cohort Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Jian Wang ◽  
Bowen Du ◽  
Yujian Wu ◽  
Zhuoyan Li ◽  
Qian Chen ◽  
...  
Keyword(s):  
Weight Gain ◽  
Left Ventricle ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Interventricular Septum ◽  
Birth Cohort Study ◽  
Gestational Weight ◽  
Concentric Hypertrophy ◽  
Septal Thickness ◽  
And Function

Background: Maternal gestational weight gain (GWG) may be associated with cardiovascular diseases in the offspring from childhood to adulthood. We aimed to investigate the association between maternal GWG and the left ventricle (LV) geometry and function in the offspring, and explore the influence of the intrauterine environment on early childhood cardiac change.Methods: Data of 981 mother-offspring pairs from the Shanghai Birth Cohort was used. Maternal pre-pregnancy weight and height, weight in the first trimester (≤ 12 weeks), and before delivery were measured. The echocardiography, blood pressure, and anthropometry assessment were evaluated in the offspring at 4 years of age.Results: Interventricular septal thickness during diastole had a significantly positive correlation with total GWG [β = 0.009, (0.001, 0.017)]. In the second and third trimesters, LV mass index [β = 0.149, (0.015,0.282)], interventricular septal thickness in systole [β = 0.027, (0.011,0.043)], and in diastole [β = 0.014, (0.005,0.023)] were positively associated with GWG. The risks of eccentric [OR = 1.115, (1.232, 1.010)] and concentric hypertrophy [OR = 1.133, (1.259,1.018)] increased with the elevation of maternal GWG.Conclusions: This study suggested that the excessive maternal GWG was associated with the thickening of the interventricular septum in the offspring, especially during the second and third trimesters. Excessive GWG in the second and third trimesters was a risk factor for LV eccentric and concentric hypertrophy in the offspring.

scholarly journals Association of gestational weight gain with cesarean section: a prospective birth cohort study in Southwest China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lujiao Huang ◽  
Ju Zhang ◽  
Hong Sun ◽  
Hongli Dong ◽  
Run Li ◽  
...  
Keyword(s):  
Weight Gain ◽  
Cesarean Section ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Southwest China ◽  
The Other ◽  
Public Health Issue ◽  
Birth Cohort Study ◽  
Gestational Weight ◽  
Prospective Birth Cohort

Abstract Background Cesarean section (CS) is a rising public health issue globally, and is particularly serious in China. Numerous studies have suggested that gestational weight gain (GWG) control may be an effective way to reduce the rate of CS. However, rare study has examined the association between GWG and CS among women in Southwest China. We proposed to examine their association based on a prospective birth cohort, and further to explore the optimal GWG range. Methods We retrieved data from a prospective birth cohort from Sichuan Provincial Hospital for Women and Children, Southwest China. Unconditional multivariable logistic regression was used to examine the association between GWG and CS by adjusting for potential confounders. In one analysis, we incorporated the GWG as a categorical variable according to the Institute of Medicine (IOM) recommendation, similar to the method used in the majority of previous studies. In the other analysis, we directly incorporated GWG as a continuous variable and natural cubic splines were used to characterize the potential nonlinear exposure-response relationship, aiming to identify the optimal GWG. We further stratified the above analysis by pre-pregnancy BMI and GDM, and then a heterogeneity test based on a multivariate meta-analysis was conducted to examine whether the stratum specific estimations agreed with each other. Results A total of 1363 participants were included. By adopting the IOM recommendation, the adjusted OR of CS was 0.63 (0.47, 0.84) for insufficient GWG and 1.42 (1.06, 1.88) for excessive GWG. After stratification by pre-pregnancy BMI, we found a higher risk of CS in associated with excessive GWG in the stratum of underweight compared with the other strata, which implied that pre-pregnancy BMI may be an effect modifier. By applying a flexible spline regression, the optimal GWG levels in terms of reducing the CS rate based on our data were more stringent than those of IOM recommendation, which were 9–12 kg for underweight women, < 19 kg for normal weight women and < 10 kg for overweight/obese women. Conclusions These results suggested that a more stringent recommendation should be applied in Southwest China, and that more attention should be given to underweight women.

scholarly journals Association of Gestational Weight Gain with Cesarean Section: A Prospective Birth Cohort Study in Southwest China

2020 ◽  
Author(s):  
Lujiao Huang ◽  
Ju Zhang ◽  
Hong Sun ◽  
Hongli Dong ◽  
Run Li ◽  
...  
Keyword(s):  
Weight Gain ◽  
Cesarean Section ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Southwest China ◽  
Public Health Issue ◽  
Birth Cohort Study ◽  
Institute Of Medicine ◽  
Gestational Weight ◽  
Prospective Birth Cohort

Abstract Background: Cesarean section (CS) is a rising public health issue globally, which is even worse in China. Numerous studies have suggested that gestational weight gain (GWG) control may be an effective way to reduce the rate of CS. However, rare study has examined the association between GWG and CS among women in Southwest China. We proposed to examine their association based on a prospective birth cohort, and further to explore the optimal GWG range.Methods: We retrieved data from a prospective birth cohort conducted in Sichuan Provincial Hospital for Women and Children, Southwest China. Unconditional multivariable logistic regression was used to examine the association between GWG and CS by adjusting for potential confounders. In one analysis, we incorporated the GWG as categorical variable according to the Institute of Medicine (IOM) recommendation, just as the majority of previous studies did. In the other analysis, we directly incorporated the GWG as continuous variable and natural cubic splines was used to characterize the potential nonlinear exposure-response relationship, aiming to identify the optimal GWG. We further stratified the above analysis by pre-pregnancy BMI and GDM, and then a heterogeneity test based on multivariate meta-analysis was conducted to examine whether the stratum specific estimation agreed with each other.Results: A total of 1363 participants were included. By adopting the IOM recommendation, the adjusted OR of CS was 0.63 (0.47, 0.84) for insufficient GWG and 1.42 (1.06, 1.88) for excessive GWG respectively. When stratified by pre-pregnancy BMI, we further found that BMI may be an effect modifier with a higher risk of excessive GWG seen in the underweight women. By applying a flexible spline regression, the optimal GWG in term of reducing CS based on our data were more stringent than that of IOM recommendation, which were 9-12 kg for underweight women, <20 kg for normal weight women and <10 kg for overweight/obese women. Conclusion: These results suggested a more stringent recommendation should be applied in Southwest China, and more attention should be given to those underweight women.

scholarly journals Pre-pregnancy BMI, gestational weight gain and breast-feeding: a cohort study in China

2016 ◽  
Vol 20 (6) ◽  
pp. 1001-1008 ◽  
Author(s):  
Xing-Yong Tao ◽  
Kun Huang ◽  
Shuang-Qin Yan ◽  
A-Zhu Zuo ◽  
Rui-Wen Tao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Breast Feeding ◽  
Early Termination ◽  
Birth Cohort Study ◽  
Exclusive Breast Feeding ◽  
Gestational Weight ◽  
Urban City

AbstractObjectiveThe purpose of the present study was to examine the influence of maternal pre-pregnancy BMI and gestational weight gain (GWG) on initiation and duration of infant breast-feeding in a prospective birth cohort study.DesignBreast-feeding information was collected at 1, 3, 6 and 12 months postpartum. The association of pre-pregnancy BMI and GWG with delayed lactogenesis II and termination of exclusive breast-feeding was assessed with logistic regression analysis. The risk of early termination of any breast-feeding during the first year postpartum was assessed with Cox proportional hazards models.SettingUrban city in China.SubjectsWomen with infants from the Ma’anshan Birth Cohort Study (n 3196).ResultsThe median duration of any breast-feeding in this cohort was 7·0 months. Pre-pregnancy obese women had higher risks of delayed lactogenesis II (risk ratio=1·89; 95 % CI 1·04, 3·43) and early termination of any breast-feeding (hazard ratio=1·38; 95 % CI 1·09, 1·75) adjusted for potential maternal and infant confounders, when compared with normal-weight women. No differences in breast-feeding initiation or duration of exclusive breast-feeding according to pre-pregnancy BMI were found. Moreover, GWG was not associated with any poor breast-feeding outcomes.ConclusionsThe present study indicated that pre-pregnancy obesity increases the risks of delayed lactogenesis II and early termination of any breast-feeding in Chinese women.

Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort

2016 ◽  
Vol 151 ◽  
pp. 436-444 ◽  
Author(s):  
David Hervé ◽  
Nathalie Costet ◽  
Philippe Kadhel ◽  
Florence Rouget ◽  
Christine Monfort ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Prenatal Exposure ◽  
Gestational Weight

scholarly journals Non-Linear Relationships Between Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Duration of Breastfeeding

2020 ◽  
Author(s):  
Yijing Zhang ◽  
Yanfen Lin ◽  
Jian Xu ◽  
Zhong-cheng Luo ◽  
Sirui Cao ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Chinese Women ◽  
Breastfeeding Duration ◽  
Birth Cohort Study ◽  
Institute Of Medicine ◽  
Linear Regression Models ◽  
Gestational Weight

Abstract Background:Considering the potential inappropriateness of the 2009 Institute-of-Medicine criteria to Chinese women, we investigated the associations between pre-pregnancy body-mass-index (BMI), gestational-weight-gain (GWG) and breastfeeding-duration among Chinese women.Methods:This birth-cohort study included 225 mother-child pairs in Shanghai from 2010 to 2012. Mothers were interviewed during mid-to-late pregnancy and at 24-36 months postpartum. Information on pre-pregnancy BMI/GWG and breastfeeding-duration was collected during pregnancy and at 24-36 months postpartum, respectively. Using a data-driven approach based on spline-smoothing-fitting of the data, two-piecewise linear regression models were used to assess the relations between pre-pregnancy BMI, GWG and breastfeeding-duration. Results:Mothers being younger, longer daily working hours, and less time living with children per week were associated with shorter duration (P<0.05). The "inverted-U"-shaped and "flat-then-declining"-shaped associations between pre-pregnancy BMI, GWG and breastfeeding-duration were observed, respectively. Adjusting for related confounders, the increases in pre-pregnancy BMI below and above 22.5 kg/m2 were associated with an increase (P=0.044) and a marginal decrease (P=0.077) in breastfeeding-duration, respectively. One-kilogram increase in GWG was associated with 0.4-month decrease (95% CI: -0.7, -0.1) in breastfeeding-duration when GWG ≥ 17.5 kilograms, however, with nonsignificant changes when GWG <17.5 kilograms. Conclusion:Appropriate pre-pregnancy BMI (around 22.5 kg/m2) and GWG (< 17.5 kilograms) were favorable to sustained breastfeeding.

Association of gestational weight gain rate with infant anaemia in China: a birth cohort study

2020 ◽  
Vol 124 (12) ◽  
pp. 1285-1292
Author(s):  
Shaohua Yin ◽  
Yubo Zhou ◽  
Hongtian Li ◽  
Zhihao Cheng ◽  
Yali Zhang ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Birth Cohort Study ◽  
Maternal Weight ◽  
Third Trimester ◽  
Maternal Anaemia ◽  
Gestational Weight ◽  
Excessive Gestational Weight Gain ◽  
Increased Risk ◽  
Hb Concentration

AbstractExcessive gestational weight gain (GWG) increases the risk of maternal anaemia during pregnancy, but whether it is associated with offspring anaemia has not been investigated. We aimed to prospectively investigate the association of GWG rate in the second/third trimester with infant Hb concentration and anaemia risk. The present study comprised 13 765 infants born during 2006–2009 to mothers who participated in a trial on prenatal micronutrient supplementation. The GWG was calculated by subtracting the maternal weight at enrolment from that at end-pregnancy. The GWG rate was calculated as dividing the GWG by number of weeks between the two measurements and classified into quintiles within each category of maternal BMI. Infant Hb concentrations were measured at 6 and 12 months of age, and anaemia was defined as an Hb concentration <110 g/l. Of the 13 765 infants, 949 (6·9 %) were anaemic at 6 months and 728 (5·3 %) at 12 months. The GWG rate was inversely and linearly associated with the infant Hb concentrations at both 6 and 12 months (P < 0·001 for linearity). Compared with the middle quintile of GWG rate, the highest quintile was associated with an increased risk of anaemia at 6 months (adjusted OR 1·30, 95 % CI 1·07, 1·59) and 12 months (adjusted OR 1·74, 95 % CI 1·40, 2·17). The associations were consistently mediated by maternal anaemia during pregnancy (P < 0·001). In conclusion, excessive GWG rate appears to be associated with an increased risk of infant anaemia, partly independent of maternal anaemia during pregnancy that mediates the association.

Obesity, gestational weight gain and preterm birth: a study within the Danish National Birth Cohort

2007 ◽  
Vol 21 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Ellen Aagaard Nohr ◽  
Bodil Hammer Bech ◽  
Michael Vaeth ◽  
Kathleen M. Rasmussen ◽  
Tine Brink Henriksen ◽  
...  
Keyword(s):  
Weight Gain ◽  
Preterm Birth ◽  
Birth Cohort ◽  
Gestational Weight Gain ◽  
Gestational Weight ◽  
Danish National Birth Cohort
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