Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

Frontiers in Pharmacology ◽

10.3389/fphar.2015.00261 ◽

2015 ◽

Vol 6 ◽

Author(s):

Maria Thomas ◽

Stefan Winter ◽

Britta Klumpp ◽

Miia Turpeinen ◽

Kathrin Klein ◽

...

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

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Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator–Activated Receptor Alpha (PPARα)

Molecular Pharmacology ◽

10.1124/mol.112.082503 ◽

2013 ◽

Vol 83 (3) ◽

pp. 709-718 ◽

Author(s):

Maria Thomas ◽

Oliver Burk ◽

Britta Klumpp ◽

Benjamin A. Kandel ◽

Georg Damm ◽

...

Keyword(s):

Transcriptional Regulation ◽

Cytochrome P450 ◽

Cytochrome P450 3A4 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Hepatic Cytochrome

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Perfluorinated Alkyl Acids in Hawaiian Cetaceans and Potential Biomarkers of Effect: Peroxisome Proliferator-Activated Receptor Alpha and Cytochrome P450 4A

Environmental Science & Technology ◽

10.1021/acs.est.8b05619 ◽

2019 ◽

Vol 53 (5) ◽

pp. 2830-2839 ◽

Author(s):

Adam E. Kurtz ◽

Jessica L. Reiner ◽

Kristi L. West ◽

Brenda A. Jensen

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Cytochrome P450 4A ◽

Perfluorinated Alkyl Acids ◽

Biomarkers Of Effect ◽

Potential Biomarkers

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Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.25.108 ◽

2010 ◽

Vol 25 (1) ◽

pp. 108-111 ◽

Author(s):

Kosuke Saito ◽

Kaoru Kobayashi ◽

Yuki Mizuno ◽

Yukina Fukuchi ◽

Tomomi Furihata ◽

...

Keyword(s):

Cytochrome P450 ◽

Constitutive Androstane Receptor ◽

Peroxisome Proliferator ◽

Primary Hepatocytes ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Rat Primary Hepatocytes

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The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARα) in the common brush tail possum (Trichosurus vulpecula)

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/s1532-0456(03)00197-2 ◽

2003 ◽

Vol 136 (2) ◽

pp. 165-173 ◽

Author(s):

Suong Ngoc Thi Ngo ◽

Ross Allan McKinnon ◽

Ieva Stupans

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Trichosurus Vulpecula ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Acyl Coa Oxidase ◽

Hepatic Cytochrome

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Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

Current Medicinal Chemistry ◽

10.2174/0929867321666140303143455 ◽

2014 ◽

Vol 21 (24) ◽

pp. 2803-2821 ◽

Author(s):

Marco Fidaleo ◽

Francesca Fanelli ◽

Maria Ceru ◽

Sandra Moreno

Keyword(s):

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

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Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)32420-1 ◽

1994 ◽

Vol 269 (27) ◽

pp. 18083-18089 ◽

Author(s):

C.N. Palmer ◽

M.H. Hsu ◽

A.S. Muerhoff ◽

K.J. Griffin ◽

E.F. Johnson

Keyword(s):

Binding Site ◽

Retinoid X Receptor ◽

Peroxisome Proliferator ◽

Response Element ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Peroxisome Proliferator Response Element ◽

Retinoid X Receptor Alpha

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The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)41738-3 ◽

1992 ◽

Vol 267 (27) ◽

pp. 19051-19053 ◽

Author(s):

A.S. Muerhoff ◽

K.J. Griffin ◽

E.F. Johnson

Keyword(s):

Cytochrome P450 ◽

Clofibric Acid ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor

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Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction

Chemico-Biological Interactions ◽

10.1016/j.cbi.2021.109521 ◽

2021 ◽

pp. 109521

Author(s):

Jesus Olivero-Verbel ◽

Jack R. Harkema ◽

Robert A. Roth ◽

Patricia E. Ganey

Keyword(s):

Inflammatory Response ◽

Mouse Model ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

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Natural peroxisome proliferator-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis

Journal of Dermatological Treatment ◽

10.3109/09546634.2010.499932 ◽

2010 ◽

Vol 22 (6) ◽

pp. 359-365 ◽

Author(s):

Clarence De Belilovsky ◽

Elia Roo-Rodriguez ◽

Caroline Baudouin ◽

Franck Menu ◽

Bernard Chadoutaud ◽

...

Keyword(s):

Atopic Dermatitis ◽

Therapeutic Response ◽

Topical Steroids ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

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Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha

Environmental Pollution ◽

10.1016/j.envpol.2021.118112 ◽

2021 ◽

pp. 118112

Author(s):

Xiaohui Xu ◽

Hao Ni ◽

Yajie Guo ◽

Yongfeng Lin ◽

Jing Ji ◽

...

Keyword(s):

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Hexafluoropropylene Oxide

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