Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes

Kosuke Saito; Kaoru Kobayashi; Yuki Mizuno; Yukina Fukuchi; Tomomi Furihata; Kan Chiba

doi:10.2133/dmpk.25.108

Peroxisome Proliferator-activated Receptor Alpha (PPARα) Agonists Induce Constitutive Androstane Receptor (CAR) and Cytochrome P450 2B in Rat Primary Hepatocytes

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.25.108 ◽

2010 ◽

Vol 25 (1) ◽

pp. 108-111 ◽

Cited By ~ 18

Author(s):

Kosuke Saito ◽

Kaoru Kobayashi ◽

Yuki Mizuno ◽

Yukina Fukuchi ◽

Tomomi Furihata ◽

...

Keyword(s):

Cytochrome P450 ◽

Constitutive Androstane Receptor ◽

Peroxisome Proliferator ◽

Primary Hepatocytes ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Rat Primary Hepatocytes

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Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

Frontiers in Pharmacology ◽

10.3389/fphar.2015.00261 ◽

2015 ◽

Vol 6 ◽

Cited By ~ 11

Author(s):

Maria Thomas ◽

Stefan Winter ◽

Britta Klumpp ◽

Miia Turpeinen ◽

Kathrin Klein ◽

...

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha

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Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat

Bioscience Biotechnology and Biochemistry ◽

10.1080/09168451.2014.923302 ◽

2014 ◽

Vol 78 (9) ◽

pp. 1550-1559

Author(s):

Zein Shaban Ibrahim ◽

Mohamed Mohamed Ahmed ◽

Samir Ahmed El-Shazly ◽

Mayumi Ishizuka ◽

Shoichi Fujita

Keyword(s):

Constitutive Androstane Receptor ◽

Clofibric Acid ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha

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Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator–Activated Receptor Alpha (PPARα)

Molecular Pharmacology ◽

10.1124/mol.112.082503 ◽

2013 ◽

Vol 83 (3) ◽

pp. 709-718 ◽

Cited By ~ 54

Author(s):

Maria Thomas ◽

Oliver Burk ◽

Britta Klumpp ◽

Benjamin A. Kandel ◽

Georg Damm ◽

...

Keyword(s):

Transcriptional Regulation ◽

Cytochrome P450 ◽

Cytochrome P450 3A4 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Hepatic Cytochrome

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Perfluorinated Alkyl Acids in Hawaiian Cetaceans and Potential Biomarkers of Effect: Peroxisome Proliferator-Activated Receptor Alpha and Cytochrome P450 4A

Environmental Science & Technology ◽

10.1021/acs.est.8b05619 ◽

2019 ◽

Vol 53 (5) ◽

pp. 2830-2839 ◽

Cited By ~ 5

Author(s):

Adam E. Kurtz ◽

Jessica L. Reiner ◽

Kristi L. West ◽

Brenda A. Jensen

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Cytochrome P450 4A ◽

Perfluorinated Alkyl Acids ◽

Biomarkers Of Effect ◽

Potential Biomarkers

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Phytanic acid, a natural peroxisome proliferator‐activated receptor agonist, regulates glucose metabolism in rat primary hepatocytes

The FASEB Journal ◽

10.1096/fj.01-0816fje ◽

2002 ◽

Vol 16 (7) ◽

pp. 718-720 ◽

Cited By ~ 77

Author(s):

Manuel Heim ◽

James Johnson ◽

Franziska Boess ◽

Igor Bendik ◽

Peter Weber ◽

...

Keyword(s):

Glucose Metabolism ◽

Receptor Agonist ◽

Phytanic Acid ◽

Peroxisome Proliferator ◽

Primary Hepatocytes ◽

Peroxisome Proliferator Activated Receptor ◽

Rat Primary Hepatocytes

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Fatty acids derived from triacylglycerol hydrolysis are a significant source of ligands for peroxisome proliferator‐activated receptor‐α (PPAR‐α) in rat primary hepatocytes

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.807.19 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Jessica M. Sapiro ◽

Mara T. Mashek ◽

Douglas G. Mashek

Keyword(s):

Fatty Acids ◽

Significant Source ◽

Peroxisome Proliferator ◽

Primary Hepatocytes ◽

Peroxisome Proliferator Activated Receptor ◽

Triacylglycerol Hydrolysis ◽

Rat Primary Hepatocytes

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Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13004 ◽

2018 ◽

Vol 123 ◽

pp. 42-50 ◽

Cited By ~ 16

Author(s):

Jukka Hakkola ◽

Camilla Bernasconi ◽

Sandra Coecke ◽

Lysiane Richert ◽

Tommy B. Andersson ◽

...

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Constitutive Androstane Receptor ◽

Pregnane X Receptor ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Aryl Hydrocarbon ◽

Cytochrome P450 Induction

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The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARα) in the common brush tail possum (Trichosurus vulpecula)

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology ◽

10.1016/s1532-0456(03)00197-2 ◽

2003 ◽

Vol 136 (2) ◽

pp. 165-173 ◽

Cited By ~ 7

Author(s):

Suong Ngoc Thi Ngo ◽

Ross Allan McKinnon ◽

Ieva Stupans

Keyword(s):

Cytochrome P450 ◽

Peroxisome Proliferator ◽

Trichosurus Vulpecula ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

The Common ◽

Acyl Coa Oxidase ◽

Hepatic Cytochrome

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Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

Current Medicinal Chemistry ◽

10.2174/0929867321666140303143455 ◽

2014 ◽

Vol 21 (24) ◽

pp. 2803-2821 ◽

Cited By ~ 65

Author(s):

Marco Fidaleo ◽

Francesca Fanelli ◽

Maria Ceru ◽

Sandra Moreno

Keyword(s):

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha

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Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)32420-1 ◽

1994 ◽

Vol 269 (27) ◽

pp. 18083-18089 ◽

Cited By ~ 2

Author(s):

C.N. Palmer ◽

M.H. Hsu ◽

A.S. Muerhoff ◽

K.J. Griffin ◽

E.F. Johnson

Keyword(s):

Binding Site ◽

Retinoid X Receptor ◽

Peroxisome Proliferator ◽

Response Element ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Peroxisome Proliferator Response Element ◽

Retinoid X Receptor Alpha

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