scholarly journals Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

2019 ◽  
Vol 10 ◽  
Author(s):  
Min Li ◽  
Lexiang Cui ◽  
Xuemin Feng ◽  
Chao Wang ◽  
Yinmeng Zhang ◽  
...  
Keyword(s):  
Hippocampal Neuron ◽  
Mapk Pathway ◽  
Neuron Damage

scholarly journals Neurotropin® alleviates hippocampal neuron damage through a HIF-1α/MAPK pathway

2017 ◽  
Vol 23 (5) ◽  
pp. 428-437 ◽  
Author(s):  
Wen-Li Fang ◽  
De-Qiang Zhao ◽  
Fei Wang ◽  
Mei Li ◽  
Sheng-Nuo Fan ◽  
...  
Keyword(s):  
Hippocampal Neuron ◽  
Mapk Pathway ◽  
Neuron Damage

scholarly journals Target of HIV-1 Envelope Glycoprotein gp120–Induced Hippocampal Neuron Damage: Role of Voltage-Gated K+ Channel Kv2.1

2015 ◽  
Vol 28 (9) ◽  
pp. 495-503 ◽  
Author(s):  
Qing Zhu ◽  
Xu Song ◽  
Jing Zhou ◽  
Yixin Wang ◽  
Jianxun Xia ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Hippocampal Neuron ◽  
K Channel ◽  
Voltage Gated ◽  
Envelope Glycoprotein Gp120 ◽  
Glycoprotein Gp120 ◽  
Neuron Damage ◽  
Hiv 1

Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited

2002 ◽  
pp. 237-251 ◽  
Author(s):  
Gary W. Mathern ◽  
P. David Adelson ◽  
Leslie D. Cahan ◽  
Joao P. Leite
Keyword(s):  
Hippocampal Neuron ◽  
Human Epilepsy ◽  
Neuron Damage

scholarly journals Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Biqiong Zhang ◽  
Yaodong Zhang ◽  
Wenning Wu ◽  
Tanzhen Xu ◽  
Yanyan Yin ◽  
...  
Keyword(s):  
Hippocampal Neuron ◽  
Neuron Damage

Comprehensive epigenetic analysis of m6A modification in the hippocampal injury of diabetic rats

Epigenomics ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 1811-1824
Author(s):  
Yu Song ◽  
Qunhui Wang ◽  
Lei Li ◽  
Songyu Chen ◽  
Yuhao Zhao ◽  
...  
Keyword(s):  
Hippocampal Neuron ◽  
Cognitive Disorders ◽  
Diabetic Rats ◽  
Behavioral Tests ◽  
Rat Models ◽  
Glucose Levels ◽  
Neuron Damage ◽  
Ht22 Cell ◽  
Epigenetic Analysis ◽  
Insight Into

Aim: To study RNA N6-methyladenosine (m6A) modification in the diabetic hippocampus. Methods: Behavioral tests and staining were performed to evaluate the damage to the diabetic hippocampus in model rats. Western blotting was performed to investigate the expression of methylation-related enzymes, and flow cytometry was used to demonstrate HT22 cell apoptosis. M6A and RNA sequencing analyses were conducted to profile m6A-tagged transcripts in the diabetic hippocampus. Results: The rat models of diabetes mellitus suffered from cognitive disorders and hippocampal neuron damage. High glucose levels altered the expression of methylation-related enzymes. A total of 4890 differentially methylated m6A peaks and 63 differentially expressed genes and differentially methylated m6A sites were identified. Conclusion: The findings suggest that m6A modification is altered in the diabetic hippocampus and provide new insight into diabetic hippocampal injury.

Protective effects of TJ-960 herbal mixture on hippocampal neuron damage induced by cobalt focus in the cerebral cortex of rats

1991 ◽  
Vol 34 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Eiichi Sugaya ◽  
Atsushi Ishige ◽  
Kyoji Sekiguchi ◽  
Toshimitsu Yuzurihara ◽  
Susumu Iizuka ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Hippocampal Neuron ◽  
Protective Effects ◽  
Herbal Mixture ◽  
Neuron Damage

P102 ROLE OF ENDOGENOUS MAPK PATHWAY SUPPRESSOR ON IBD

2018 ◽  
Vol 154 (1) ◽  
pp. S52
Author(s):  
Sharad Khare ◽  
Qiong Zhang
Keyword(s):  
Mapk Pathway
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