scholarly journals Dietary fat overload reprograms brown fat mitochondria

2015 ◽  
Vol 6 ◽  
Author(s):  
Daniele Lettieri Barbato ◽  
Giuseppe Tatulli ◽  
Rolando Vegliante ◽  
Stefano M. Cannata ◽  
Sergio Bernardini ◽  
...  
Keyword(s):  
Dietary Fat ◽  
Brown Fat ◽  
Brown Fat Mitochondria

Brown fat mitochondria

1984 ◽  
Vol 9 (11) ◽  
pp. 489-491 ◽  
Author(s):  
David G. Nicholls ◽  
Eduardo Rial
Keyword(s):  
Brown Fat ◽  
Brown Fat Mitochondria

GDP binding to rat brown fat mitochondria: effects of thyroxine at different ambient temperatures

1981 ◽  
Vol 241 (3) ◽  
pp. C134-C139 ◽  
Author(s):  
U. Sundin
Keyword(s):  
Linear Increase ◽  
Reciprocal Relationship ◽  
Brown Fat ◽  
Hormone Activity ◽  
Ambient Temperatures ◽  
Heating Capacity ◽  
Brown Adipose ◽  
Induced Changes ◽  
Brown Fat Mitochondria

Reports on a reciprocal relationship between sympathetic-nerve and experimentally induced changes in thyroid-hormone activity called into question the proposed role of thyroxine in the changes seen in the brown fat after cold adaptation. Rats reared at +30, +22, and +5 degrees C received daily injections of thyroxine (1 mg/kg). After 3 wk of treatment, the thermogenic state of the tissue was assessed by measuring the capacity of the brown fat mitochondria to bind guanosine 5'-diphosphate (GDP). GDP-inhibited mitochondrial swelling, brown adipose tissue (BAT) wet weights, and mitochondrial yields were also measured. The control animals showed a linear increase in GDP binding between +30 and +5 degrees C. Thyroxine was found to lower the GDP binding markedly at +5 degrees C, less so at +22 degrees C, while no effect was evident at +30 degrees C. The values at +22 and +30 degrees C were identical. The other parameters studied all confirmed these results. The conclusion made is that the thyroxine-induced rise in basal metabolic rate lowers the critical temperature and reduces the demand for nonshivering thermogenesis. This is reflected in the reduced GDP binding and hence heating capacity of the brown fat mitochondria.

Influence of subdiaphragmatic vagotomy and brown fat sympathectomy on thermogenesis in rats

1985 ◽  
Vol 249 (3) ◽  
pp. E239-E243 ◽  
Author(s):  
P. L. Andrews ◽  
N. J. Rothwell ◽  
M. J. Stock
Keyword(s):  
Insulin Treatment ◽  
Brown Fat ◽  
Guanosine Diphosphate ◽  
Subdiaphragmatic Vagotomy ◽  
Brown Adipose ◽  
Adrenergic Antagonist ◽  
Brown Adipose Tissue Activity ◽  
Acute Injection ◽  
Brown Fat Mitochondria ◽  
Thermogenic Response

Infusion of rats with insulin (8 U/day via implanted minipump) for 7 days caused a 22% rise in resting oxygen consumption, which was inhibited by acute injection of the beta-adrenergic antagonist propranolol. Insulin treatment produced significant increases in brown fat mass, protein content, and total thermogenic activity (assessed from binding of guanosine diphosphate to isolated brown fat mitochondria), but these responses were inhibited by prior surgical sympathectomy of the tissue. Animals subjected to subdiaphragmatic vagotomy gained more weight than pair-fed, sham-operated controls and showed reductions in total energy expenditure, the acute thermogenic response to a meal and brown adipose tissue activity. Daily injections of insulin (1 U/day) prevented all of these effects of vagotomy. These data demonstrate that the changes in brown fat activity induced by exogenous insulin are mediated by the sympathetic nervous system and that the depressed thermogenesis and brown fat activity associated with vagotomy appear to be due to a relative insulin deficiency and can be reversed by treatment with the hormone.

Binding of ATP to uncoupling protein of brown fat mitochondria as studied by means of spin-labeled ATP derivatives

FEBS Letters ◽  
1991 ◽  
Vol 284 (2) ◽  
pp. 195-198 ◽  
Author(s):  
P. Jakobs ◽  
A. Braun ◽  
P. Jezek ◽  
W.E. Trommer
Keyword(s):  
Uncoupling Protein ◽  
Brown Fat ◽  
Brown Fat Mitochondria ◽  
Atp Derivatives

scholarly journals Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

Cell ◽  
2012 ◽  
Vol 151 (2) ◽  
pp. 400-413 ◽  
Author(s):  
Andriy Fedorenko ◽  
Polina V. Lishko ◽  
Yuriy Kirichok
Keyword(s):  
Fatty Acid ◽  
Brown Fat ◽  
Brown Fat Mitochondria

GDP-binding to the brown fat mitochondria of developing rats: Cold adaption and heat production

1978 ◽  
Vol 3 (2) ◽  
pp. 103 ◽  
Author(s):  
Ulf Sundin ◽  
Barbara Cannon
Keyword(s):  
Heat Production ◽  
Brown Fat ◽  
Cold Adaption ◽  
Brown Fat Mitochondria

GDP binding to hamster brown fat mitochondria is reduced during hibernation

1985 ◽  
Vol 249 (6) ◽  
pp. R689-R693 ◽  
Author(s):  
B. A. Horwitz ◽  
J. S. Hamilton ◽  
K. S. Kott
Keyword(s):  
Binding Sites ◽  
Mitochondrial Protein ◽  
Substantial Reduction ◽  
Brown Fat ◽  
Short Photoperiod ◽  
Syrian Hamsters ◽  
Hydroxyacyl Coa Dehydrogenase ◽  
Brown Fat Mitochondria ◽  
Important Site ◽  
Thermogenic Capacity

Preparation for hibernation is accompanied by increased thermogenic capacity of brown fat (BAT), an important site of thermogenesis during arousal from hibernation. This study examined whether that thermogenic capacity is reduced in hibernation and reactivated during arousal. In one set of experiments, Syrian hamsters were exposed to short photoperiod (10:14 light-dark) and cold (7 degrees C). Those not hibernating at death (n = 10) served as controls for those that were (n = 9). A third group (n = 10) was killed 80–90 min after arousal was initiated by manual perturbation. Mitochondrial GDP binding (nmol/mg mitochondrial protein) was used to estimate thermogenic capacity. In a second experimental series, BAT citrate (si)-synthase and 3-hydroxyacyl-CoA dehydrogenase activities were measured in hibernating and nonhibernating hamsters. Although there were no differences in the maximum activities of these enzymes, GDP binding was markedly lower in the hibernators relative to the nonhibernators (0.214 +/- 0.031 vs. 0.535 +/- 0.039). However, in the partially aroused hamsters, GDP binding had doubled (0.438 +/- 0.04). Thus hibernation is accompanied by a substantial reduction of BAT thermogenic capacity (as manifested by GDP binding), which is reversed during arousal. The rapidity of this reversal indicates that it does not involve the synthesis of new GDP binding sites.

A Molecular Biology Study of the Uncoupling Protein of Brown Fat Mitochondria. A Contribution to the Analysis of Genes of Mitochondrial Carriers

1989 ◽  
pp. 251-260 ◽  
Author(s):  
Frederic Bouillaud ◽  
Serge Raimbault ◽  
Louis Casteilla ◽  
Anne-Marie Cassard ◽  
Daniel Ricquier
Keyword(s):  
Molecular Biology ◽  
Uncoupling Protein ◽  
Brown Fat ◽  
Mitochondrial Carriers ◽  
Brown Fat Mitochondria
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