Ground penetrating radar investigations at the Lake Condah Mission Cemetery: Locating unmarked graves in areas with extensive subsurface disturbance

Ground penetrating radar (GPR) was used to non-invasively map the location of unmarkedgraves within the Lake Condah Mission Cemetery in western Victoria as a means of siting future interments. This cemetery was associated with the former Lake Condah Mission (established in 1869) and continues to be an important site for local Indigenous people. It is anecdotally thought to contain more than 100 graves however only 26 are currently marked. The GPR survey identified an additional 14 probable unmarked graves as well as 49 other areas that may contain one or more unmarked burials. The extensive subsurface disturbance present at the site and the presence of many extant tree roots made the effective interpretation of the GPR data difficult. Despite this, it was still possible to delineate areas where no unmarked graves are present. This is an important outcome for managing the cultural heritage of the cemetery because it identifies areas where new graves can be emplaced in a culturally appropriate fashion. This demonstrates the utility of GPR as a means of effectively managing heritage sites containing unmarked graves, even when substantial subsurface disturbance is present.

The Stereological Analysis and Spatial Distribution of Neurons in the Human Subthalamic Nucleus

The subthalamic nucleus (STN) is a small, ovoid structure, and an important site of deep brain stimulation (DBS) for the treatment of Parkinson’s disease. Although the STN is a clinically important structure, there are many unresolved issues with regard to it. These issues are especially related to the anatomical subdivision, neuronal phenotype, neuronal composition, and spatial distribution. In this study, we have examined the expression pattern of 8 neuronal markers [nNOS, NeuN, parvalbumin (PV), calbindin (CB), calretinin (CR), FOXP2, NKX2.1, and PAX6] in the adult human STN. All of the examined markers, except CB, were present in the STN. To determine the neuronal density, we have performed stereological analysis on Nissl-stained and immunohistochemical slides of positive markers. The stereology data were also used to develop a three-dimensional map of the spatial distribution of neurons within the STN. The nNOS population exhibited the largest neuronal density. The estimated total number of nNOS STN neurons is 281,308 ± 38,967 (± 13.85%). The STN neuronal subpopulations can be divided into two groups: one with a neuronal density of approximately 3,300 neurons/mm3 and the other with a neuronal density of approximately 2,200 neurons/mm3. The largest density of STN neurons was observed along the ventromedial border of the STN and the density gradually decreased toward the dorsolateral border. In this study, we have demonstrated the presence of 7 neuronal markers in the STN, three of which were not previously described in the human STN. The human STN is a collection of diverse, intermixed neuronal subpopulations, and our data, as far as the cytoarchitectonics is concerned, did not support the tripartite STN subdivision.

An Introduction to Spiral Steroids

In addition to the classical steroids, which have cholesterol as a precursor, there are steroids with 7-dehydrocholesterol as a precursor. This review describes the identification of these steroids, their biosynthesis and some aspects of their function. There are three classes of these compounds, distinguished by the number of their carbon atoms, 23, 24 and 25. Each class has a spiral steroid and is a phosphodiester. Up until these investigations, no spiral steroids or steroid phosphodiesters were known. There are at least 13 compounds of which six have been purified to near homogeneity. Each one has been characterized by its mass and proposed composition. They function by regulating the NaK-ATPase. Based on the tissues in which they have been detected, each class of compound seems to regulate a different isoform of the NaK-ATPase. This is an important site of endocrine regulation.

“This changes things”: Children, targeting, and the making of precision

Avoidance of civilian casualties increasingly affects the political calculus of legitimacy in armed conflict. “Collateral damage” is a problem that can be managed through the material production of precision, but it is also the case that precision is a problem managed through the cultural production of collateral damage. Bearing decisively on popular perceptions of ethical conduct in recourse to political violence, childhood is an important site of meaning-making in this process. In pop culture, news dispatches, and social media, children, as quintessential innocents, figure prominently where the dire human consequences of imprecision are depicted. Children thus affect the practical “precision” of even the most advanced weapons, perhaps precluding a strike for their presence, potentially coloring it with their corpses. But who count as children, how, when, where, and why are not at all settled questions. Drawing insights from what the 2015 film, Eye in the Sky, reveals about a key social technology of governance we have already internalized, I explore how childhood is itself a terrain of engagement in the (un)making of precision.

Archaeological study of the Varzuga River

The Varzuga River on the northern shore of the White Sea is an important site for the archaeology of Russian Lapland. Here the archaeological study of this region began. The work provides a historiographical overview from the first finds in the XIX century to the excavations of 2009–2013, when two objects were examined: the fortification of the beginning of the XV century and the rural cemetery of the XIV–XVIII centuries. The reconstruction of a small rural fortress was made. We managed to find the first church of the village of the end of the XIV — beginning of the XV century. Interesting information about the late medieval burial rite has been obtained. Anthropological materials speak about the Karelian basis of the medieval population of the Terek coast. According to the results of archaeological work, it is clear that in the middle of the XIV century, a large Korela settlement with a church already existed on the site of the modern village.

‘Essentially an American Institution Planted on Foreign Soil’: The American Library in Paris, the Paris Herald, the Paris Tribune and Ex Libris

In 1920, the American Library in Paris (ALP) was incorporated, with the desire to ‘be a somewhat adequate representation of American life and thought’ in the city. This paper will argue that the ALP - an institution established for overseas soldiers in 1918, which became its own entity in 1920 and celebrated a century of service in 2020 - would do more than represent America in the interwar period: it would play a role in shaping American identity as well. Through archival materials, this paper explores the ALP’s representation in the three periodicals most imbricated with its interwar existence: the Paris editions of the Chicago Tribune and the New York Herald, and the little magazine, Ex Libris. I argue that the ALP - in both its physical and psychic forms - was an important site for the formation of transnational American identity in the interwar period, and that it strived to weigh in on conversations about emerging literary movements, including modernism and the Harlem Renaissance. American identity, as the Library represented it, combined national exceptionalism with a true desire for transnational cooperation. It was firmly at home on international soil, and well-versed in the era’s literary debates.

The Biopolitics of Language Learning

This chapter critically examines modes of English language learning that capitalize on the linguistic malleability of youth, collectively known as early English education (yeongeo jogi gyoyuk), arguing that the embodied nature of language learning makes such investments an important site for the inculcation of neoliberal subjectivities. A prominent aspect of the Korean English fever was the emphasis placed on exposing youths to English at an increasingly earlier age. Focusing on the case of early study abroad (jogi yuhak), this chapter argues that these aged-based projects of English language learning are not simply outcomes of increasing competition that drives down the age for first exposure to English; instead, they are facilitated by a deep sense of anxiety that derives from viewing youth as a limited resource, and in this sense, they are a site of biopolitics, where bodies of youth come to be incorporated into the logic of neoliberalism.

Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells

HCV infection induces inflammation leading to fibrosis, cirrhosis, and cancer. The current study identifies the mechanisms leading to the activation of the NLRP3 inflammasome in hepatocytes, which is an important site of viral replication.

Fans and Fan Activism

Fan communities have been actively celebrating popular culture like the Harry Potter books and films, the music and fashion of Beyoncé, Korean pop sensation BTS, and the Star Wars media empire, as well as nearly every professional sports team for decades; and research on fans and fan communities has grown alongside them. The proliferation of internet and social media access has made fandom even more prominent. This chapter summarizes and synthesizes existing fandom research while highlighting how digital media have influenced fandom. First, it argues that fandom is best conceptualized as an ideal type organized around consumption, knowledge, engagement, community, identity, and emotional connection and that the internet has made each element more accessible. It then describes how fandom research has demonstrated that—as subcultures—fan communities can replicate and enact many of the same class, gender, and race inequities seen in broader society, although not identically. These inequities are evident in how society responds to different fandoms as well as fans’ experiences within their communities. Finally, it summarizes the growing literature on how fan communities have been mobilized for pro-social and activist behavior. These fan activists are adept at such behavior because they have tapped into the skills and knowledge they developed through their fandom, their proximity to mass cultural events like book and movie releases, and their communities’ potential as a source of bloc recruitment. In sum, fan communities are an important site of community and identity and an important subject of analysis in an increasingly digitized world.

The evolution of gender-inclusive language. Evidence from the German Bundestag, 1949-2021

Gender-inclusive language is an important issue in the struggle for political equality between women and men. Parliaments are an important site in this struggle as they both reflect and shape gender-relations in society. Based on a novel high-quality corpus of all its debates we study the evolution of gender-fair language in the German parliament, Bundestag, between 1949 and 2021. As a "gender language" with a grammatical gender, German offers ideal conditions to inspect semantically symmetric male and female forms of personal nouns. Our analysis of more than 2.5 million occurrences of 1,600 lemmas of personal nouns reveals that female forms had been virtually non-existent in debates before experiencing a dramatic increase since the 1980s. This evolution in language use has been induced by the gender, partisan affiliation and generational affiliation of MPs.