scholarly journals Expression of South East Asian Ovalocytic Band 3 Disrupts Erythroblast Cytokinesis and Reticulocyte Maturation

2020 ◽  
Vol 11 ◽  
Author(s):  
Joanna F. Flatt ◽  
Christian J. Stevens-Hernandez ◽  
Nicola M. Cogan ◽  
Daniel J. Eggleston ◽  
Nicole M. Haines ◽  
...  
Keyword(s):  
East Asian ◽  
Band 3 ◽  
Reticulocyte Maturation

Structural Studies on the Effects of the Deletion in the Red Cell Anion Exchanger (band 3, AE1) Associated with South East Asian Ovalocytosis

1999 ◽  
Vol 285 (3) ◽  
pp. 1289-1307 ◽  
Author(s):  
Eric J. Chambers ◽  
Graham B. Bloomberg ◽  
Susan M. Ring ◽  
Michael J.A. Tanner
Keyword(s):  
Anion Exchanger ◽  
East Asian ◽  
Band 3 ◽  
Red Cell ◽  
Structural Studies

scholarly journals Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells

2000 ◽  
Vol 351 (3) ◽  
pp. 839-839 ◽  
Author(s):  
L. J. BRUCE ◽  
O. WRONG ◽  
A. M. TOYE ◽  
M. T. YOUNG ◽  
G. OGLE ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Renal Tubular Acidosis ◽  
East Asian ◽  
New Guinea ◽  
Band 3 ◽  
Red Cells ◽  
Renal Tubular

scholarly journals The expression of the abnormal human red cell anion transporter from South-East Asian ovalocytes (band 3 SAO) inXenopusoocytes

FEBS Letters ◽  
1993 ◽  
Vol 330 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Jonathan D. Groves ◽  
Susan M. Ring ◽  
Ann E. Schofield ◽  
Michael J.A. Tanner
Keyword(s):  
East Asian ◽  
Band 3 ◽  
Red Cell ◽  
Anion Transporter

scholarly journals Monoclonal antibodies recognizing epitopes on the extracellular face and intracellular N-terminus of the human erythrocyte anion transporter (band 3) and their application to the analysis of South East Asian ovalocytes

Blood ◽  
1995 ◽  
Vol 85 (10) ◽  
pp. 2929-2936 ◽  
Author(s):  
JS Smythe ◽  
FA Spring ◽  
B Gardner ◽  
SF Parsons ◽  
PA Judson ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Human Erythrocyte ◽  
East Asian ◽  
Band 3 ◽  
Extracellular Loop ◽  
Binding Studies ◽  
Cooperative Interactions ◽  
The Third ◽  
Anion Transporter

This report describes the production and characterization of 13 rodent monoclonal antibodies to the human erythrocyte anion transport protein AE1 (syn. band 3). Eleven antibodies (4 murine and 7 rat) recognize epitopes dependent on the integrity of the third extracellular loop of the protein. Two antibodies (1 murine and 1 rat) recognize epitopes on the N-terminal cytoplasmic domain. Quantitative binding studies using radioiodinated IgG and Fab fragments of antibodies to extracellular epitopes on AE1 ranged from 77,000 to 313,000 (IgG) and from 241,000 to 772,000 (Fab) molecules bound at saturation. The results indicate that the epitopes recognized by different antibodies vary in their accessibility and suggest that there is heterogeneity in the organization of individual AE1 molecules in the red blood cell membrane. Quantitative binding studies on South East Asian ovalocytes using several antibodies to AE1 and an anti-Wrb show a marked reduction in the number of antibody molecules bound at saturation. These results are consistent with the existence of highly cooperative interactions between transmembrane domains of AE1 in normal erythrocytes and the disruption of these interactions in the variant AE1 found in South East Asian ovalocytes.

scholarly journals Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells

2000 ◽  
Vol 350 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Lesley J. BRUCE ◽  
Oliver WRONG ◽  
Ashley M. TOYE ◽  
Mark T. YOUNG ◽  
Graham OGLE ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
East Asian ◽  
Band 3 ◽  
Anion Transport ◽  
Red Cells ◽  
Red Cell ◽  
Transport Activity ◽  
Anion Transport Activity ◽  
Renal Tubular ◽  
Compound Heterozygotes

We describe three mutations of the red-cell anion exchanger band 3 (AE1, SLC4A1) gene associated with distal renal tubular acidosis (dRTA) in families from Malaysia and Papua New Guinea: Gly701 → Asp (G701D), Ala858 → Asp (A858D) and deletion of Val850 (δV850). The mutations A858D and ∆V850 are novel; all three mutations seem to be restricted to South-East Asian populations. South-East Asian ovalocytosis (SAO), resulting from the band 3 deletion of residues 400–408, occurred in many of the families but did not itself result in dRTA. Compound heterozygotes of each of the dRTA mutations with SAO all had dRTA, evidence of haemolytic anaemia and abnormal red-cell properties. The A858D mutation showed dominant inheritance and the recessive ∆V850 and G701D mutations showed a pseudo-dominant phenotype when the transport-inactive SAO allele was also present. Red-cell and Xenopus oocyte expression studies showed that the ∆V850 and A858D mutant proteins have greatly decreased anion transport when present as compound heterozygotes (∆V850/A858D, ∆V850/SAO or A858D/SAO). Red cells with A858D/SAO had only 3% of the SO42- efflux of normal cells, the lowest anion transport activity so far reported for human red cells. The results suggest dRTA might arise by a different mechanism for each mutation. We confirm that the G701D mutant protein has an absolute requirement for glycophorin A for movement to the cell surface. We suggest that the dominant A858D mutant protein is possibly mis-targeted to an inappropriate plasma membrane domain in the renal tubular cell, and that the recessive ∆V850 mutation might give dRTA because of its decreased anion transport activity.

scholarly journals Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells

2000 ◽  
Vol 350 (1) ◽  
pp. 41 ◽  
Author(s):  
Lesley J. BRUCE ◽  
Oliver WRONG ◽  
Ashley M. TOYE ◽  
Mark T. YOUNG ◽  
Graham OGLE ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
Renal Tubular Acidosis ◽  
East Asian ◽  
New Guinea ◽  
Band 3 ◽  
Red Cells ◽  
Renal Tubular

Maxims of Foreign Policy

Itinerario ◽  
2000 ◽  
Vol 24 (2) ◽  
pp. 62-79
Author(s):  
W.J. Boot
Keyword(s):  
Foreign Policy ◽  
Sixteenth Century ◽  
Foreign Relations ◽  
East Asian ◽  
Modern Period ◽  
Cultural Sphere ◽  
Japanese Identity

In the pre-modern period, Japanese identity was articulated in contrast with China. It was, however, articulated in reference to criteria that were commonly accepted in the whole East-Asian cultural sphere; criteria, therefore, that were Chinese in origin.One of the fields in which Japan's conception of a Japanese identity was enacted was that of foreign relations, i.e. of Japan's relations with China, the various kingdoms in Korea, and from the second half of the sixteenth century onwards, with the Portuguese, Spaniards, Dutchmen, and the Kingdom of the Ryūkū.

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