scholarly journals Validation of a Portable Blood Gas Analyzer for Use in Challenging Field Conditions at High Altitude

2021 ◽  
Vol 11 ◽  
Author(s):  
Janek Nawrocki ◽  
Michael Furian ◽  
Aline Buergin ◽  
Laura Mayer ◽  
Simon Schneider ◽  
...  
Keyword(s):  
High Altitude ◽  
Research Question ◽  
Field Conditions ◽  
Diagnostic Tools ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Essential Point ◽  
Blood Samples ◽  
Siemens Healthcare ◽  
Arterial Blood

BackgroundNovel, portable blood gas analyzers (BGAs) may serve as essential point-of-care tools in remote regions, during air travel or in ambulance services but they have not been extensively validated.Research QuestionWe compared accuracy of a portable BGA to a validated stationary device.MethodsIn healthy individuals and patients with chronic obstructive pulmonary disease participating in clinical field studies at different altitudes, arterial blood samples were obtained at rest and during exercise in a hospital at 760 m and in a high altitude clinic at 3100 m. Paired measurements by a portable BGA (EPOC, Siemens Healthcare) and a stationary BGA (Rapidpoint500, Siemens Healthcare) were performed to compute bias (mean difference) and limits of agreement (95% CI of bias).ResultsOf 105 individuals, 248 arterial blood samples were analyzed, 108 at 760 m, 140 at 3100 m. Ranges of values measured by portable BGA were: pH 7.241−7.473, PaCO2 21.5−52.5 mmHg, and PaO2 45.5−107.1 mmHg. Bias (95% CI) between devices were: pH 0.007 (−0.029 to 0.044), PaCO2 −0.3 mmHg (−4.8 to 4.2), and PaO2 −0.2 mmHg (−9.1 to 4.7). For pH, agreement between devices was improved by the equation to correct pH by portable BGA = −1.37 + pHmeasured × 1.19; bias after correction −0.007 (−0.023 to 0.009). The portable BGA was easily handled and worked reliably.InterpretationAccuracy of blood gas analysis by the portable BGA in comparison to the reference BGA was adequate for clinical use. Because of portability and ease of handling, portable BGA are valuable diagnostic tools for use in everyday practice as well as under challenging field conditions.

Blood gas changes during panting in a small East African antelope, the dik-dik

1978 ◽  
Vol 44 (4) ◽  
pp. 534-537 ◽  
Author(s):  
M. Maskrey ◽  
P. P. Hoppe ◽  
O. S. Bamford
Keyword(s):  
Heat Stress ◽  
Heat Exposure ◽  
Blood Gases ◽  
Respiratory Alkalosis ◽  
Second Phase ◽  
Blood Gas ◽  
Climatic Chamber ◽  
East African ◽  
Blood Samples ◽  
Arterial Blood

Five adult male dik-dik (Madoqua kirkii) were exposed in a climatic chamber to an air temperature of 45 degrees C. Measurements were made of rectal temperature (Tre) and respiratory frequency (f) and arterial blood samples taken before and during heat exposure were analyzed for pH, PCO2 and PO2. During exposure, Tre and f increased in all animals. In the first 80 min dik-dik displayed thermal tachypnea and minor changes in blood gases. Continued exposure lead to hyperpnea accompanied by a fall in PaCO2 and a rise in pH. PaCO2 at first fell and then increased toward or above control levels. The dik-dik did not display second phase breathing. This observation confirms that second phase breathing is not essential to the development of respiratory alkalosis. The main conclusion of the study is that the dik-dik, unlike another heat-adapted antelope, the wildebeest (Taylor, Robertshaw, and Hoffmann. Am. J. Physiol. 217:907–910, 1969), is unable to resist alkalosis during heat stress.

scholarly journals Correlation between arterial and venous blood gas analysis parameters in patients with acute exacerbation of chronic obstructive pulmonary disease

2012 ◽  
Vol 140 (7-8) ◽  
pp. 436-440 ◽  
Author(s):  
Milos Novovic ◽  
Vesna Topic
Keyword(s):  
Acute Exacerbation ◽  
Venous Blood ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Obstructive Pulmonary Disease ◽  
Acute Exacerbation Of Copd ◽  
Arterial Blood ◽  
Exacerbation Of Copd ◽  
Venous Blood Gas ◽  
Oxygen Status

Introduction. Arterial blood gas (ABG) analyses have an important role in the assessment and monitoring of the metabolic and oxygen status of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Arterial puncture could have a lot of adverse effects, while sampling of venous blood is simpler and is not so invasive. Objective. The aim of this study was to evaluate whether venous blood gas (VBG) values of pH, partial pressure of carbon dioxide (PCO2), partial oxygen pressure (PO2), bicarbonate (HCO3), and venous and arterial blood oxygen saturation (SO2) can reliably predict ABG levels in patients with acute exacerbation of COPD. Methods. Forty-seven patients with a prior diagnosis of COPD were included in this prospective study. The patients with acute exacerbation of this disease were examined at the General Hospital EMS Department in Prijepolje. ABG samples were taken immediately after venous sampling, and both were analyzed. Results. The Pearson correlation coefficients between arterial and venous parameters were 0.828, 0.877, 0.599, 0.896 and 0.312 for pH, PCO2, PO2, HCO3 and SO2, respectively. The statistically significant correlation between arterial and venous pH, PCO2 and HCO3, values was found in patients with acute exacerbation of COPD (p<0.001). Conclusion. When we cannot provide arterial blood for analysis, venous values of the pH, Pv,CO2 and HCO3 parameters can be an alternative to their arterial equivalents in the interpretation of the metabolic status in patients with acute exacerbation of COPD, while the values of venous Pv,O2 and Sv,O2 cannot be used as predictors in the assessment of oxygen status of such patients.

Arterial blood gas tensions during breath-hold diving in the Korean ama

1993 ◽  
Vol 75 (1) ◽  
pp. 285-293 ◽  
Author(s):  
J. Qvist ◽  
W. E. Hurford ◽  
Y. S. Park ◽  
P. Radermacher ◽  
K. J. Falke ◽  
...  
Keyword(s):  
Radial Artery ◽  
Breath Hold ◽  
Blood Gas ◽  
Arterial Pco2 ◽  
Blood Samples ◽  
Arterial Blood Gas ◽  
Time Limits ◽  
Arterial Blood ◽  
Normal Ranges ◽  
Arterial Po2

Korean female unassisted divers (cachido ama) breath-hold dive > 100 times to depths of 3–7 m during a work day. We sought to determine the extent of arterial hypoxemia during normal working dives and reasonable time limits for breath-hold diving by measuring radial artery blood gas tensions and pH in five cachido ama who dove to a fixed depth of 4–5 m and then continued to breath hold for various times after their return to the surface. Eighty-two blood samples were withdrawn from indwelling radial artery catheters during 37 ocean dives. We measured compression hyperoxia [arterial PO2 = 141 +/- 24 (SD) Torr] and hypercapnia (arterial PCO2 = 46.6 +/- 2.4 Torr) at depth. Mean arterial PO2 near the end of breath-hold dives lasting 32–95 s (62 +/- 14 s) was decreased (62.6 +/- 13.5 Torr). Mean arterial PCO2 reached 49.9 +/- 5.4 Torr. Complete return of these values to their baseline did not occur until 15–20 s after breathing was resumed. In dives of usual working duration (< 30 s), blood gas tensions remained within normal ranges. Detailed analysis of hemoglobin components and intrinsic oxygenation properties revealed no evidence for adaptive changes that could increase the tolerance of the ama to hypoxic or hypothermic conditions associated with repetitive diving.

Pregnant sheep develop hypoxaemia during short-term anaesthesia for caesarean delivery

2018 ◽  
Vol 52 (5) ◽  
pp. 497-503
Author(s):  
Gabrielle C Musk ◽  
Matthew W Kemp
Keyword(s):  
Partial Pressure ◽  
Endotracheal Tube ◽  
Caesarean Delivery ◽  
Supplemental Oxygen ◽  
Blood Gas ◽  
Short Term ◽  
Blood Samples ◽  
Arterial Blood ◽  
Pregnant Sheep ◽  
Pregnant Ewe

Short-term anaesthesia of the pregnant ewe may be required for caesarean delivery of a preterm foetus within a research protocol. The aim of this study was to evaluate and compare the acid-base and haematological status of the ewe and foetus at the time of surgical delivery by collecting maternal and foetal arterial blood samples. Fifteen date-mated singleton-pregnant merino cross ewes at 122.0 (±0.5) days of gestation were anaesthetised with a combination of midazolam (0.5 mg/kg) and ketamine (10 mg/kg) by intravenous injection. A subarachnoid injection of lidocaine (60 mg) was given to desensitise the caudal abdomen. Supplemental oxygen was not provided, and an endotracheal tube was not placed in the ewe’s trachea. The development of maternal respiratory acidosis (hypercapnia) and hypoxaemia was anticipated. Samples of arterial blood for blood gas analyses were collected simultaneously from the radial artery of the ewe and the umbilical artery of the foetus immediately after delivery. The results from the maternal blood samples were within the normal range for pH, partial pressure of carbon dioxide in arterial blood (PaCO2), base excess, glucose, lactate, haematocrit and haemoglobin concentration. The maternal partial pressure of oxygen in arterial blood (PaO2) revealed hypoxaemia: 45.2 (41.1–53.4) mmHg. Foetal arterial blood gas analysis revealed hypoxaemia (15.0 ± 3.1 mmHg) and hypoglycaemia (0.1 (0.1–1.1) mmol/L). The benefit of providing supplemental oxygen and/or placing an endotracheal tube must be carefully weighed against the benefit of saving time when prompt delivery of the foetus is planned. In this study the pregnant ewe developed severe hypoxaemia, and this abnormality may have contributed to a low foetal PaO2.

Venous blood gases: is it useful in COPD?

2017 ◽  
Vol 42 (1) ◽  
Author(s):  
Akkan Avci ◽  
Salim Satar ◽  
Erdem Aksay ◽  
Mürsel Koçer ◽  
Muhammed Semih Gedik ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Pearson Correlation ◽  
Venous Blood ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Acute Exacerbation Of Copd ◽  
Arterial Blood ◽  
Exacerbation Of Copd ◽  
Venous Blood Gas

AbstractIntroductionThe present study aims to investigate whether values of venous blood gas sampling can be used instead of arterial blood gas values in the evaluation of blood gas for the emergency service patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).MethodsPatients diagnosed COPD and identified to have acute exacerbation of COPD based on acute exacerbation of COPD criteria participated in the study. Data from arterial and venous samples were compared using Spearman and Pearson correlation and Bland-Altman analysis.ResultsNinety patients were included in this study. The results indicated statistically significant correlations between venous blood gas pH, pODiscussion and conclusionThe findings of the study suggest that some formulations can be used to estimate pH and pCO

Effect of Aspirin and Statins on Pulmonary Function and Inflammation in Patients with AECOPD

Nano LIFE ◽  
2020 ◽  
pp. 2050005
Author(s):  
Guangqing Duan ◽  
Kaixuan Lv ◽  
Lyu Juncheng ◽  
Na Tian ◽  
Lichun Zhang ◽  
...  
Keyword(s):  
Lung Function ◽  
Nonparametric Test ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Obstructive Pulmonary Disease ◽  
Arterial Blood Gas ◽  
Medication Group ◽  
Coronary Ct ◽  
Arterial Blood ◽  
Retrospective Clinical Study

Background: The influence of coronary atherosclerosis and related treatment drugs on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) development requires in-depth study. The study investigated the effect of coronary artery calcification (CAC) and drugs for CAC on the development of AECOPD. Methods: This retrospective clinical study recruited subjects with AECOPD from May 2017 to May 2019. All subjects performed spirometry and coronary computed tomography (CT), and were divided into three groups according to whether coronary CT revealed CAC and whether they had received oral aspirin and statins: AECOPD group, AECOPD[Formula: see text]CAC nonmedication and AECOPD[Formula: see text]CAC medication. The t-test and nonparametric test were used for analyzing the lung function, arterial blood gas, routine blood and lipid between groups. Results: Compared with the AECOPD group, Lym% were significantly higher ([Formula: see text]) in both the AECOPD[Formula: see text]CAC nonmedication and the AECOPD[Formula: see text]CAC medication. The AECOPD[Formula: see text]CAC medication group also had significantly higher PaO2 ([Formula: see text]). WBC, Neu, and Neu% in the AECOPD[Formula: see text]CAC medication group were significantly lower ([Formula: see text]) compared to the AECOPD group. Conclusions: Aspirin and statins for the treatment of cardiovascular diseases may be linked to improving lung function, normalizing blood gas levels, and reducing inflammation in patients with AECOPD and CAC. Further, randomized controlled trials are needed to explore this topic.

Sign in / Sign up

Export Citation Format

Share Document