scholarly journals Effect of Paraplegia on the Time Course of Exogenous Fatty Acid Incorporation Into the Plasma Triacylglycerol Pool in the Postprandial State

2021 ◽  
Vol 12 ◽  
Author(s):  
David W. McMillan ◽  
Gregory C. Henderson ◽  
Mark S. Nash ◽  
Kevin A. Jacobs
Keyword(s):  
Fatty Acid ◽  
Dietary Fat ◽  
Time Course ◽  
Statistical Significance ◽  
Fat Metabolism ◽  
Fat Absorption ◽  
Exogenous Fatty Acid ◽  
Lower Amplitude ◽  
Cord Injury ◽  
Dietary Fat Absorption

Spinal cord injury (SCI) results in disordered fat metabolism. Autonomic decentralization might contribute to dyslipidemia in SCI, in part by influencing the uptake of dietary fats through the gut-lymph complex. However, the neurogenic contributions to dietary fat metabolism are unknown in this population. We present a subset of results from an ongoing registered clinical trial (NCT03691532) related to dietary fat absorption. We fed a standardized (20 kcal⋅kgFFM–1) liquid meal tolerance test (50% carb, 35% fat, and 15% protein) that contained stable isotope lipid tracer (5 mg⋅kgFFM–1 [U-13C]palmitate) to persons with and without motor complete thoracic SCI. Blood samples were collected at six postprandial time points over 400 min. Changes in dietary fatty acid incorporated into the triacylglycerol (TAG) pool (“exogenous TAG”) were used as a marker of dietary fat absorption. This biomarker showed that those with paraplegia had a lower amplitude than non-injured participants at Post240 (52.4 ± 11.0 vs. 77.5 ± 16.0 μM), although this failed to reach statistical significance (p = 0.328). However, group differences in the time course of absorption were notable. The injury level was also strongly correlated with time-to-peak exogenous TAG concentration (r = −0.806, p = 0.012), with higher injuries resulting in a slower rise in exogenous TAG. This time course documenting exogenous TAG change is the first to show a potential neurogenic alteration in SCI dietary fat absorption.

The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice

2000 ◽  
Vol 14 (13) ◽  
pp. 2040-2046 ◽  
Author(s):  
Galya Vassileva ◽  
Leslie Huwyler ◽  
Kevin Poirier ◽  
Luis B. Agellon ◽  
Matthew J. Toth
Keyword(s):  
Fatty Acid ◽  
Dietary Fat ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fat Absorption ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Dietary Fat Absorption

scholarly journals Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia

1999 ◽  
Vol 81 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Kim G. Jackson ◽  
Antonios Zampelas ◽  
Jacky M. E. Knapper ◽  
Caroline C. Culverwell ◽  
John Wright ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dietary Fat ◽  
Peak Concentration ◽  
Fat Absorption ◽  
Response Curves ◽  
Postprandial Lipaemia ◽  
Apo B ◽  
Delayed Entry ◽  
Dietary Fat Absorption ◽  
Meal Consumption

The extent and duration of postprandial lipaemia have been linked to risk of CHD but the influence of dietary variables on, and the relative contributions of, exogenous (chylomicron) and endogenous (VLDL) triacylglycerols to the total lipaemic response have not been comprehensively evaluated. In the present study the triacylglycerol, apolipoprotein (apo) B-48 and retinyl ester (RE) responses to three test meals of varying monounsaturated (MUFA) and saturated fatty acid (SFA) content were measured in the triacylglycerol-rich lipoprotein (TRL) fraction of plasma (ρ = 1·006 g/ml) for 9 h after meal consumption. Fifteen healthy normolipidaemic young men consumed, on separate occasions, three test meals which were identical apart from their MUFA and SFA contents. Expressed as a percentage of total energy the MUFA/SFA contents of the meals were: (1) 12 %/17 %; (2) 17 %/12 % and (3) 24 %/5 %. The contribution of the intestinally-derived lipoproteins (chylomicrons) to the lipaemic response was investigated by determining the time to reach peak concentration and the total and incremental areas under the time response curves (AUC and incremental AUC) for RE, apoB-48 and triacylglycerol in the TRL fraction. No significant differences in these measurements were observed for the three meals. However, visual comparison of the postprandial responses to the three meals suggested that as meal MUFA content increased there was a tendency for the triacylglycerol, apoB-48 and RE responses to become biphasic as opposed to the typical monophasic response seen with the 12 % MUFA/17 % SFA meal. Comparison of the apoB-48 and RE responses for the three test meals confirmed other workers’ findings of delayed entry of RE relative to apoB-48 in TRL. The value of the two markers in investigating dietary fat absorption and metabolism is discussed.

132-OR: Peripheral Serotonin Regulates Dietary Fat Absorption and Intestinal Chylomicron Production

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 132-OR
Author(s):  
FITORE RAKA ◽  
KHOSROW ADELI
Keyword(s):  
Dietary Fat ◽  
Fat Absorption ◽  
Dietary Fat Absorption

PREVENTION OF APPARENT ADIPOSITY BY FRACTIONS OF DISTILLED COW URINE: A NON-INVASIVE APPROACH

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (03) ◽  
pp. 73-78
Author(s):  
Ketan Hatware ◽  
Sanjay Sharma ◽  
Ashwini Deshpande ◽  
Kiran Patil ◽  
Sravani Karri ◽  
...  
Keyword(s):  
Dietary Fat ◽  
Fat Absorption ◽  
Invasive Approach ◽  
Non Invasive ◽  
Area Of Interest ◽  
Liquid Liquid Extraction ◽  
Pathological Conditions ◽  
Cow Urine ◽  
Bioactive Fraction ◽  
Dietary Fat Absorption

Owing to the multifactorial pathological conditions management of obesity is a challenging problem. finding an effective and safe remedy is a huge area of interest for many scientists and healthcare professionals in the field of biomedicine. There is a traditional claim that fresh cow urine and its distillate have anti-obesity activity. The present study aimed to assess the bioactive fraction of distillated cow urine having anti-obesity potential. Distilled cow urine was extracted by liquid-liquid extraction method using different solvents. Distilled cow urine and all the fractions were assessed for the anti-obesity activity by analysing non-invasive parameters. The distilled cow urine and it’s methanolic as well as butanolic fractions show significant anti-obesity potential. It has been found that body weight reduced without affecting food consumption. This effect was probably due to the reduction in dietary fat absorption by reducing the pancreatic lipase activity and enhancing its excretion in faeces. Further research is required to explore the exact mechanism of action.

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