Neural Correlates of Cognitive-Attentional Syndrome: An fMRI Study on Repetitive Negative Thinking Induction and Resting State Functional Connectivity

AbstractThe default mode network (DMN) is thought to capture intrinsic activity of the brain and has been instrumental in understanding the dynamics of the brain. However, the DMN has not been without critics; both conceptual and empirical. The empirical criticisms caution against physiological noise as a source for the reported connectivity in the DMN. Smaller flip angles (FAs) have been modelled and shown to reduce physiological noise in BOLD signal recordings. A previous functional MRI (fMRI) study with flickering checkerboard stimuli, manipulated FAs to show that activity in the posterior-cingulate cortex (PCC) and precuneus is prone to physiological noise. This raises questions about studies that show activations in these areas (PCC and precuneus) with a fixed FA and the role of these areas in brain networks like DMN. Given the prominent role of PCC and precuneus in DMN, we studied the effect of FAs on the resting-state functional connectivity involving these areas in DMN. We used four FAs and recorded resting-state activity in a 3-T scanner. The results show PCC and precuneus BOLD functional connectivity is inconsistent. We lend support to previous empirical criticisms of DMN, linking its activity to physiological noise. Our results add to concerns about PCC and precuneus related BOLD activity and their putative role in DMN. Alongside previous studies we advocate using smaller flip angles as an empirical tool to investigate physiological noise in fMRI studies.

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Belief in Communism and Theory of Mind

Frontiers in Psychology ◽

10.3389/fpsyg.2021.697251 ◽

2021 ◽

Vol 12 ◽

Author(s):

Outong Chen ◽

Fang Guan ◽

Yu Du ◽

Yijun Su ◽

Hui Yang ◽

...

Keyword(s):

Functional Connectivity ◽

Theory Of Mind ◽

Resting State ◽

Brain Activity ◽

Neural Correlates ◽

Resting State Functional Connectivity ◽

Neural Basis ◽

Spontaneous Brain Activity ◽

Multiple Regions ◽

Left Thalamus

A belief in communism refers to the unquestionable trust and belief in the justness of communism. Although former studies have discussed the political aim and social value of communism, the cognitive neural basis of a belief in communism remains largely unknown. In this study, we determined the behavioral and neural correlates between a belief in communism and a theory of mind (ToM). For study 1, questionnaire scores were measured and for study 2, regional homogeneity (ReHo) and resting-state functional connectivity (rsFC) were used as an index for resting-state functional MRI (rs-fMRI), as measured by the Belief in Communism Scale (BCS). The results showed that a belief in communism is associated with higher ReHo in the left thalamus and lower ReHo in the left medial frontal gyrus (MFG). Furthermore, the results of the rsFC analysis revealed that strength of functional connectivity between the left thalamus and the bilateral precuneus is negatively associated with a belief in communism. Hence, this study provides evidence that spontaneous brain activity in multiple regions, which is associated with ToM capacity, contributes to a belief in communism.

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