Resting state functional connectivity and neural correlates of face-name encoding in patients with ischemic vascular lesions with and without the involvement of the left inferior frontal gyrus

Cortex ◽  
2019 ◽  
Vol 113 ◽  
pp. 15-28 ◽  
Author(s):  
Alana X. Batista ◽  
Paulo R. Bazán ◽  
Adriana B. Conforto ◽  
Maria da Graça M. Martins ◽  
Maurício Hoshino ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Neural Correlates ◽  
Vascular Lesions ◽  
Resting State Functional Connectivity ◽  
Left Inferior Frontal Gyrus

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Yun Wang ◽  
Kai-Juan Yan ◽  
Chen-Xiao Fan ◽  
Xiao-Nian Luo ◽  
Yuan Zhou
Keyword(s):  
Nucleus Accumbens ◽  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Resting State Fmri ◽  
Resting State Functional Connectivity ◽  
Functional Architecture ◽  
Superior Frontal Gyrus ◽  
Eyes Closed ◽  
Orbital Part

Abstract Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) during resting state. NAc contains different subdivisions and they may play different roles in addiction. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the NAc subdivisions in amphetamine-type stimulant abusers (ATSAs). Methods The present study recruited 17 male ATSAs and 22 healthy male controls. All the subjects underwent resting-state functional magnetic resonance imaging (fMRI) with their eyes closed. The NAc was divided into core-like and shell-like subdivisions. We used seed-based resting-state functional connectivity (RSFC) analyses to identify differences in brain functional architecture between ATSAs and healthy controls (HCs). Results ATSAs had lower positive RSFCs with all of the NAc subdivisions over the left orbital part of superior frontal gyrus and higher positive RSFCs with the NAc subdivisions over the left opercular part of inferior frontal gyrus than HCs, which indicates common abnormalities across the NAc subdivisions in ATSAs. In addition, the RSFCs between the NAc subdivisions and the left orbital part of superior frontal gyrus were negatively correlated with the addiction severity in ATSAs. Conclusion These results provide evidence that there are common RSFC patterns of the NAc subdivisions in ATSAs. The abnormality indicated by disrupted functional connectivity between the NAc subdivisions and prefrontal cortex suggests abnormal interaction between the rewarding process and cognitive control in ATSAs. Our results shed insight on the neurobiological mechanisms of ATSA and suggest potential novel therapeutic targets for treatment and intervention of ATSAs.

scholarly journals A-47 Resting-State Functional Connectivity Associated with Contact Level in Female Varsity Athletes

2020 ◽  
Vol 35 (5) ◽  
pp. 643-643
Author(s):  
A Wilson ◽  
W D Stevens ◽  
M Wojtowicz
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Female Athletes ◽  
Inferior Frontal Gyrus ◽  
Resting State Functional Connectivity ◽  
Contact Sport ◽  
Contact Sports ◽  
Varsity Athletes ◽  
Patient Health ◽  
Contact Exposure

Abstract Objective The effects of participation in contact sports on brain functioning is a growing area of concern in the athlete population. This pilot study examined differences in resting-state functional connectivity (rsFC) associated with level of contact in female varsity student athletes. Method Resting-state functional magnetic resonance imaging (fMRI) scans were collected from 29 female university athletes. Level of contact was characterized by active participation in collision sports (n = 13) and contact sports (n = 16). Athletes completed baseline testing including self-reported psychological measures. RsFC was compared between groups using Independent Component Analysis (ICA) within the default mode (DMN), frontoparietal (FPN), dorsal attention (DAN), salience (SN), and sensorimotor (SMN) networks. Results Collision sport athletes reported younger age at first sport (M = 4.7, SD = 1.2) and fewer past concussions (Md = 0, Range = 0–3) compared to contact sport athletes (M = 7.5, SD = 3.4; Md = 7.5, Range = 0–6; ps < .05). Collision sport athletes also reported fewer symptoms of depression on the Patient Health Questionnaire-9 (p = 0.03). Collision sport athletes had decreased rsFC between the SMN and the left inferior frontal gyrus (T = −5.6, pFDR = 0.008) compared to the contact sport athletes. This difference in rsFC was not associated with age at first sport or prior concussion history. Conclusions Consistent with prior studies of varsity athletes, altered patterns of rsFC were observed in areas supporting somatomotor function in female athletes with suspected greater contact exposure. Further research is necessary to examine whether these neural changes are attributable to greater exposure to sub-concussive hits or other factors, such as differences in visuomotor abilities.

scholarly journals Romantic jealousy is positively associated with fronto-striatal, insula and limbic responses to angry faces

2018 ◽  
Author(s):  
Xiaoxiao Zheng ◽  
Lizhu Luo ◽  
Jialin Li ◽  
Lei Xu ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Dorsal Striatum ◽  
Neural Representation ◽  
Resting State Functional Connectivity ◽  
Romantic Jealousy ◽  
The Right ◽  
Emotional Face ◽  
Emotional Responsivity

AbstractRomantic jealousy is a complex social emotion combining the different primary emotions of anger, fear and sadness. Previous evidence has suggested the involvement of fronto-striatal dopaminergic circuitry in clinical pathological jealousy, although little is known about overlaps with the neural representation of primary emotions involved in non-morbid jealousy. In the current study, 85 healthy subjects underwent fMRI during resting state and an emotional face recognition paradigm. A total of 150 faces (happy, angry, fearful, sad, neutral) were presented and subjects were required to identify the expression and rate its intensity. Trait romantic jealousy was assessed using the Multidimensional Jealousy Scale. Behavioral results showed that only intensity ratings of angry faces were positively associated with subjects’ jealousy scores. During processing of angry versus neutral expression faces, subjects with higher jealousy scores exhibited greater activation in the right thalamus, insula, fusiform gyrus and hippocampus, left dorsal striatum and superior parietal lobule and bilateral cerebellum and inferior frontal gyrus after controlling for trait aggression and sex. Functional connectivity between the inferior frontal gyrus and caudate was also increased. No associations with resting state functional connectivity were found. Overall, the present study demonstrates an association between romantic jealousy and increased intensity ratings of angry faces as well as in activity and functional connectivity of dorsal striatal-inferior frontal circuitry. Thus, increased emotional responsivity to social threat and enhanced activity in limbic regions and dopaminergic fronto-striatal circuitry may be features of both non-morbid and pathological jealousy.

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