Higher Negative Self-Reference Level in Patients With Personality Disorders and Suicide Attempt(s) History During Biological Treatment for Major Depressive Disorder: Clinical Implications

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD).Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory (BDI13). Associations between depression changes on BDI13 domains (Negative Self-Reference, Sad Mood, and Performance Impairment), treatment arm, time, and clinical variables were tested in a mixed linear model.Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI13 were personality disorders (+2.1 points), a past history of suicide attempt(s) (+1.7 points), age under 65 years old (+1.5 points), and female sex (+1.1 points).Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt(s).

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Associations of Non-Alcoholic Beverages with Major Depressive Disorder History and Depressive Symptoms Clusters in a Sample of Overweight Adults

Nutrients ◽

10.3390/nu12103202 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3202

Author(s):

M. Ángeles Pérez-Ara ◽

Margalida Gili ◽

Marjolein Visser ◽

Brenda W.J.H. Penninx ◽

Ingeborg A. Brouwer ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Symptoms ◽

Depressive Disorder ◽

Longitudinal Analysis ◽

Soft Drinks ◽

Alcoholic Beverages ◽

Major Depressive ◽

Cross Sectional ◽

History Of ◽

Overweight Adults

Background: Meta-analysis of observational studies concluded that soft drinks may increase the risk of depression, while high consumption of coffee and tea may reduce the risk. Objectives were to explore the associations between the consumption of soft drinks, coffee or tea and: (1) a history of major depressive disorder (MDD) and (2) the severity of depressive symptoms clusters (mood, cognitive and somatic/vegetative symptoms). Methods: Cross-sectional and longitudinal analysis based on baseline and 12-month-follow-up data collected from four countries participating in the European MooDFOOD prevention trial. In total, 941 overweight adults with subsyndromal depressive symptoms aged 18 to 75 years were analyzed. History of MDD, depressive symptoms and beverages intake were assessed. Results: Sugar-sweetened soft drinks were positively related to MDD history rates whereas soft drinks with non-nutritive sweeteners were inversely related for the high vs. low categories of intake. Longitudinal analysis showed no significant associations between beverages and mood, cognitive and somatic/vegetative clusters. Conclusion: Our findings point toward a relationship between soft drinks and past MDD diagnoses depending on how they are sweetened while we found no association with coffee and tea. No significant effects were found between any studied beverages and the depressive symptoms clusters in a sample of overweight adults.

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History of suicide attempt and right superior temporal gyrus volume in youth with treatment-resistant major depressive disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2018.07.030 ◽

2018 ◽

Vol 239 ◽

pp. 291-294 ◽

Cited By ~ 11

Author(s):

Quinn McLellan ◽

T. Christopher Wilkes ◽

Rose Swansburg ◽

Natalia Jaworska ◽

Lisa Marie Langevin ◽

...

Keyword(s):

Major Depressive Disorder ◽

Suicide Attempt ◽

Depressive Disorder ◽

Superior Temporal Gyrus ◽

Treatment Resistant ◽

Major Depressive ◽

History Of

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Increased fear-potentiated startle in major depressive disorder patients with lifetime history of suicide attempt

Journal of Affective Disorders ◽

10.1016/j.jad.2014.03.027 ◽

2014 ◽

Vol 162 ◽

pp. 34-38 ◽

Cited By ~ 18

Author(s):

Elizabeth D. Ballard ◽

Dawn F. Ionescu ◽

Jennifer L. Vande Voort ◽

Elizabeth E. Slonena ◽

Jose A. Franco-Chaves ◽

...

Keyword(s):

Major Depressive Disorder ◽

Suicide Attempt ◽

Depressive Disorder ◽

Major Depressive ◽

Lifetime History ◽

History Of ◽

Fear Potentiated Startle

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Personality disorders and depression

Psychological Medicine ◽

10.1017/s0033291702005780 ◽

2002 ◽

Vol 32 (6) ◽

pp. 1049-1057 ◽

Cited By ~ 61

Author(s):

M. FAVA ◽

A. H. FARABAUGH ◽

A. H. SICKINGER ◽

E. WRIGHT ◽

J. E. ALPERT ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Symptoms ◽

Personality Disorder ◽

Depressive Disorder ◽

Personality Disorders ◽

Antidepressant Treatment ◽

Significant Proportion ◽

Obsessive Compulsive ◽

Major Depressive ◽

Before And After

Background. Personality disorders (PDs) were assessed among depressed out-patients by clinical interview before and after antidepressant treatment with fluoxetine to assess the degree of stability of PD diagnoses and determine whether changes in PD diagnoses across treatment are related to the degree of improvement in depressive symptoms.Method. Three hundred and eighty-four out-patients (55% women; mean age = 39.9±10.5) with major depressive disorder (MDD) diagnosed with the SCID-P were enrolled into an 8 week trial of open treatment with fluoxetine 20 mg/day. The SCID-II was administered to diagnose PDs at baseline and endpoint.Results. A significant proportion (64%) of our depressed out-patients met criteria for at least one co-morbid personality disorder. Following 8 weeks of fluoxetine treatment, there was a significant reduction in the proportion of patients meeting criteria for avoidant, dependent, passive-aggressive, paranoid and narcissistic PDs. From baseline to endpoint, there was also a significant reduction in the mean number of criteria met for paranoid, schizotypal, narcissistic, borderline, avoidant, dependent, obsessive–compulsive, passive aggressive and self-defeating personality disorders. While changes in cluster diagnoses were not significantly related to improvement in depressive symptoms, there were significant relationships between degree of reduction in depressive symptoms (percentage change in HAM-D-17 scores) and degree of change in the number of criteria met for paranoid, narcissistic, borderline and dependent personality disorders.Conclusions. Personality disorder diagnoses were found to be common among untreated out-patients with major depressive disorder. A significant proportion of these patients no longer met criteria for personality disorders following antidepressant treatment, and changes in personality disorder traits were significantly related to degree of improvement in depressive symptoms in some but not all personality disorders. These findings suggest that the lack of stability of PD diagnoses among patients with current MDD may be attributable in part to a direct effect of antidepressant treatment on behaviours and attitudes that comprise PDs.

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Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder

Cureus ◽

10.7759/cureus.9061 ◽

2020 ◽

Author(s):

Robert D Abbott ◽

Kyle Sherwin ◽

Hannah Klopf ◽

Holly J Mattingly ◽

Kelly Brogan

Keyword(s):

Quality Of Life ◽

Major Depressive Disorder ◽

Depressive Symptoms ◽

Depressive Disorder ◽

Lifestyle Intervention ◽

Major Depressive ◽

History Of ◽

Online Lifestyle

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Major depressive disorder history among patients who sought blepharoplasty operation in a private ophthalmology hospital in Saudi Arabia

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.733 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S535-S535

Author(s):

D. Nagui Rizk ◽

M. Abo Ghanima

Keyword(s):

Saudi Arabia ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Body Dysmorphic Disorder ◽

Past History ◽

Self Assessment ◽

Major Depressive ◽

History Of ◽

Competing Interest ◽

Number Of Individuals

BackgroundMuch attention has focused on body dysmorphic disorder among patients undergoing plastic surgeries, but there has been little evaluation of their past history of major depressive disorder (MDD).AimTo estimate the prevalence rate of past history of Major Depressive Disorder (MDD) in patients undergoing Blepharoplasty operation in a private ophthalmology hospital in Jeddah, Saudi Arabia.MethodsAll patients who have undergone blepharoplasty operation during the period from 5 April to 4 October 2016 (6 months) were included. Previous psychiatric history was taken from the patients by psychiatric assessment and self-assessment questionnaire, diagnosis of Major Depressive Disorder (MDD) confirmed previously by consultant psychiatrists in patients’ health records was included.ResultsOne hundred and forty-eight persons undergone blepharoplasty in the hospital from 5 April to 4 October 2016. They were 89 females (60%) and 59 males (40%). Among those 148 persons, 10 patients were previously diagnosed with major depressive disorder by consultant psychiatrists with a percentage of 6.8% where 5 were females (5.6% of 89 females) and 5 were males (8.5% of 59 males).ConclusionsThe number of individuals who present for blepharoplasty operation with a history of Major Depressive disorder needs to take a special consideration. A link between MDD and cosmetic operation decision should be further studied.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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