scholarly journals Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Xusan Xu ◽  
Shucun Luo ◽  
Xia Wen ◽  
Xiaoxia Wang ◽  
Jingwen Yin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Negative Symptoms ◽  
Clinical Performance ◽  
Clinical Manifestations ◽  
Analysis Of Covariance ◽  
First Episode ◽  
Imaging Data ◽  
Resting State Functional Connectivity ◽  
Mental Symptoms ◽  
First Episode Schizophrenia

Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal–striatal–thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. Fifty-two FES patients and 52 matched healthy controls were recruited. All subjects underwent genotyping via the improved multiplex ligation detection reaction technique and scanning with magnetic resonance imaging (MRI) to provide orbitofrontal–striatal–thalamic functional and structural imaging data. A two-way analysis of covariance model was employed to examine abnormal brain connectivities, and Spearman correlations were applied to estimate the relationships between brain connectivity and clinical manifestations. In the FES group, those with the SAP97 rs3915512 TT genotype showed lower structural and functional connectivity than A allele carriers between the orbitofrontal gyrus and striatum/thalamus. In the FES group, negative correlations were found between resting-state functional connectivity (RSFC) in the orbitofrontal gyrus and thalamus, and positive symptoms between structural connections in the orbitofrontal gyrus and striatum and cognitive functions, and positive correlations were suggested between RSFC in the orbitofrontal gyrus and thalamus and negative symptoms. Our findings suggested that the SAP97 rs3915512 polymorphism may be involved in mental symptoms and cognitive dysfunction in FES patients by influencing structural and functional connectivity of the orbitofrontal–striatal and orbitofrontal–thalamic regions.

scholarly journals Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Woo-Sung Kim ◽  
Guangfan Shen ◽  
Congcong Liu ◽  
Nam-In Kang ◽  
Keon-Hak Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Negative Relationship ◽  
First Episode ◽  
Frontal Pole ◽  
Resting State Functional Connectivity ◽  
Significant Group ◽  
Attenuated Psychosis Syndrome ◽  
The Right ◽  
First Episode Schizophrenia

Abstract Altered resting-state functional connectivity (FC) of the amygdala (AMY) has been demonstrated to be implicated in schizophrenia (SZ) and attenuated psychosis syndrome (APS). Specifically, no prior work has investigated FC in individuals with APS using subregions of the AMY as seed regions of interest. The present study examined AMY subregion-based FC in individuals with APS and first-episode schizophrenia (FES) and healthy controls (HCs). The resting state FC maps of the three AMY subregions were computed and compared across the three groups. Correlation analysis was also performed to examine the relationship between the Z-values of regions showing significant group differences and symptom rating scores. Individuals with APS showed hyperconnectivity between the right centromedial AMY (CMA) and left frontal pole cortex (FPC) and between the laterobasal AMY and brain stem and right inferior lateral occipital cortex compared to HCs. Patients with FES showed hyperconnectivity between the right superficial AMY and left occipital pole cortex and between the left CMA and left thalamus compared to the APS and HCs respectively. A negative relationship was observed between the connectivity strength of the CMA with the FPC and negative-others score of the Brief Core Schema Scales in the APS group. We observed different altered FC with subregions of the AMY in individuals with APS and FES compared to HCs. These results shed light on the pathogenetic mechanisms underpinning the development of APS and SZ.

scholarly journals SU101. Altered Resting-State Functional Connectivity of Striatum in First-Episode Schizophrenia

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S197-S198
Author(s):  
Yi Wang ◽  
Karen S. Y. Hung ◽  
Michelle Y. Deng ◽  
Simon S. Y. Lui ◽  
Joe C. Y. Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

Fronto-parietal white matter microstructural deficits are linked to performance IQ in a first-episode schizophrenia Han Chinese sample

2012 ◽  
Vol 43 (10) ◽  
pp. 2047-2056 ◽  
Author(s):  
Q. Wang ◽  
C. Cheung ◽  
W. Deng ◽  
M. Li ◽  
C. Huang ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Deficits ◽  
Negative Symptoms ◽  
Diffusion Tensor ◽  
Clinical Manifestations ◽  
First Episode ◽  
Chinese Sample ◽  
Schizophrenia Group ◽  
Core Deficit ◽  
First Episode Schizophrenia

BackgroundEvidence shows that cognitive deficits and white matter (WM) dysconnectivity can independently be associated with clinical manifestations in schizophrenia. It is important to explore this triadic relationship in order to investigate whether the triplet could serve as potential extended endophenotypes of schizophrenia.MethodDiffusion tensor images and clinical performances were evaluated in 122 individuals with first-episode schizophrenia and 122 age- and gender-matched controls. In addition, 65 of 122 of the patient group and 40 of 122 controls were measured using intelligence quotient (IQ) testing.ResultsThe schizophrenia group showed lower fractional anisotropy (FA) values than controls in the right cerebral frontal lobar sub-gyral (RFSG) WM. The schizophrenia group also showed a significant positive correlation between FA in the RFSG and performance IQ (PIQ); in turn, their PIQ score showed a significant negative correlation with negative syndromes.ConclusionsOverall, these findings support the hypothesis that WM deficits may be a core deficit that contributes to cognitive deficits as well as to negative symptoms.

scholarly journals Comparative Study on the Functional Connectivity of Amygdala and Hippocampal Neural Circuits in Patients With First-Episode Schizophrenia and Other High-Risk Populations

2021 ◽  
Vol 12 ◽  
Author(s):  
Xinrui Wang ◽  
Zhiyang Yin ◽  
Qikun Sun ◽  
Xiaowei Jiang ◽  
Li Chao ◽  
...  
Keyword(s):  
High Risk ◽  
Functional Connectivity ◽  
Correlation Analysis ◽  
Limbic System ◽  
Neural Circuits ◽  
Analysis Of Covariance ◽  
First Episode ◽  
High Risk Populations ◽  
First Episode Schizophrenia ◽  
Post Hoc

Objective: Cortical-limbic system neural circuit abnormalities are closely related to the onset of schizophrenia (SZ). The amygdala, hippocampus, cingulate, and prefrontal lobe are important components of the loop. In this study, we compared resting-state functional connectivity (rs-FC) between the amygdala/hippocampus and cingulate/prefrontal regions among patients with first-episode schizophrenia (FE-SZ), high risk populations with SZ (HR-SZ), and healthy controls (HCs). By discovering the abnormal pattern of the cortical-limbic system of SZ and HR-SZ, we attempted to elucidate the pathophysiological mechanism of SZ.Method: This study collected seventy-five FE-SZ patients, 59 HR-SZ, and 64 HCs. Analysis of variance and chi-square tests were used to analyze their demographic data. Analysis of covariance and post-hoc analysis were performed on the functional connectivity of the three groups. Finally, correlation analysis between the significant brain functional connectivity value and the scale score was performed.Results: The results of the analysis of covariance showed that there were significant differences in rs-FC between the amygdala and the right middle cingulate and between the hippocampus and the bilateral medial superior frontal gyrus among the three groups (Gaussian random field (GRF)-corrected voxel p < 0.001, cluster p < 0.05). Post hoc comparisons showed that the rs-FC of the amygdala—right middle cingulate and the hippocampus—bilateral medial superior frontal gyrus in patients with SZ was significantly lower than that of HR-SZ and HC (Bonferroni corrected p < 0.001). There was no significant difference between the HR-SZ and HC groups. The results of the correlation analysis showed that rs-FC of the hippocampus-medial frontal gyrus in patients with SZ was positively correlated with core depression factor scores on the Hamilton Depression Scale (P = 0.006, R = 0.357).Conclusion: There were different patterns of functional connectivity impairment in the amygdala and hippocampal neural circuits in the schizophrenic cortical-limbic system, and these patterns may be more useful than genetics as state-related imaging changes of the disease.

scholarly journals M149. THE TOPOGRAPHY OF STRIATAL DOPAMINE AND SYMPTOMS IN PSYCHOSIS: AN INTEGRATIVE PET AND MRI STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S192-S192
Author(s):  
Rob McCutcheon ◽  
Sameer Jauhar ◽  
Fiona Pepper ◽  
Matthew Nour ◽  
Maria Rogdaki ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Negative Symptoms ◽  
Striatal Dopamine ◽  
Psychotic Symptoms ◽  
Dopamine Synthesis ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
Positron Emission ◽  
Mri Study

Abstract Background Striatal dopamine dysfunction is proposed to underlie symptoms in psychosis, yet it is not known how changes in a single neurotransmitter could underlie the heterogenous presentations that are seen clinically. One hypothesis is that the symptomatic consequences of aberrant dopamine signalling may depend on where within the striatum dysfunction occurs. Positron emission tomography (PET) allows for the measurement of dopamine function across the striatum. However, when using typical atlas-based parcellation methods, the collinearity between measures of dopamine function within each striatal subdivision precludes investigation of this hypothesis. Methods We use a novel and data-driven parcellation method to address the above, and investigate relationships between spatial variability in dopamine synthesis capacity and psychotic symptoms. We employ a multimodal imaging approach combining 18F-DOPA PET and resting state MRI in 29 unmedicated and minimally-treated patients with first episode psychosis and 21 healthy controls. In each participant, we use resting state functional connectivity maps to quantify the functional connectivity of each striatal voxel to cortical networks. Network-specific striatal dopamine synthesis capacity (Kicer) was calculated for the resulting connectivity defined parcellations. Results Connectivity defined parcellations generated Kicer values with equivalent reliability, and significantly greater orthogonality to standard anatomical parcellation methods. Dopamine function within striatal areas connected to the default mode network is strongly associated with negative symptoms (p<0.001). Discussion These findings suggest that individual differences in the topography of striatal dopamine dysfunction contribute to shaping psychotic symptomatology.

scholarly journals Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEG

2019 ◽  
Vol 24 ◽  
pp. 101959 ◽  
Author(s):  
Kristin K. Lottman ◽  
Timothy J. Gawne ◽  
Nina V. Kraguljac ◽  
Jeffrey F. Killen ◽  
Meredith A. Reid ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia ◽  
7T Fmri
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