scholarly journals Efficacy of a Single Dose of Pregabalin on Signs of Anxiety in Cats During Transportation—A Pilot Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Terttu Lamminen ◽  
Mira Korpivaara ◽  
Minna Suokko ◽  
John Aspegrén ◽  
Clara Palestrini ◽  
...  
Keyword(s):  
Pilot Study ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Oral Solution ◽  
Common Adverse Event ◽  
External Observer ◽  
Clinical Safety ◽  
Fear And Anxiety ◽  
User Friendly ◽  
Anxiety And Fear

Objectives: The aim of this clinical pilot study was to evaluate the dosage, efficacy, and clinical safety of a single oral dose of pregabalin in cats that experience fear and anxiety when placed into a carrier and transported by car.Methods: Thirteen client-owned cats were enrolled in a blinded, randomized, crossover study with three treatment days approximately 1 week apart. The cats were assigned to receive pregabalin oral solution at dosages of 5 and 10 mg/kg and placebo in a randomized order, one treatment per week. Treatment was administered ~90 min before placing the cat into a carrier and starting transportation. Efficacy was assessed by the owners using a categorical scale and, based on video recordings, by an external observer, both blinded to the treatment.Results: Owners assessed that cats given pregabalin displayed less vocalization, restlessness, and panting during transportation than did cats given placebo. Correlation between owners' and external observer's assessment of the overall treatment effect was good (0.63, p < 0.01), which confirms the owners' ability to observe reliably their own cat's behavior. Transient mild ataxia was the most common adverse event reported. The human commercial formulation used in this study was found difficult or very difficult to administer by 79% of the owners.Conclusions and Relevance: Based on results of this pilot study, a single oral dose of pregabalin was well tolerated and decreased signs of anxiety and fear associated with car transportation in cats, as evaluated by blinded owners and external observer. The use of pregabalin prior to traveling may improve cat welfare and compliance for transportation. Further studies are needed to investigate the use of oral pregabalin in cats to alleviate signs of anxiety and fear associated with transportation and sequelae, like veterinary visits, and to develop a more user-friendly formulation.

scholarly journals Design of Fear and Anxiety of COVID-19 Assessment Tool in Spanish Adult Population

2021 ◽  
Vol 11 (3) ◽  
pp. 328
Author(s):  
Juan Gómez-Salgado ◽  
Regina Allande-Cussó ◽  
Sara Domínguez-Salas ◽  
Juan Jesús García-Iglesias ◽  
Valle Coronado-Vázquez ◽  
...  
Keyword(s):  
Pilot Study ◽  
Assessment Tool ◽  
Adult Population ◽  
Weighted Kappa ◽  
Spanish Population ◽  
Validity And Reliability ◽  
Reliability Study ◽  
Final Version ◽  
Fear And Anxiety ◽  
Anxiety And Fear

The aim of this study was to develop a specific scale to measure anxiety and fear levels in the general Spanish population. For this, a transcultural adaptation to Spanish of the fear of coronavirus disease 2019 (COVID-19) scale, in its original version of 10 items, was carried out. Then, the Anxiety and Fear of COVID-19 Assessment Scale (AMICO, for its acronym in Spanish) was designed by translating the tool and Delphi technique into three rounds. Ten experts participated voluntarily, and inter-observer match rates and the reliability study of the designed scale were calculated. A pilot study was carried out with the final version of the scale for the validity and reliability study. The instrument did not raise problems in semantic and cultural terms during the first and second rounds of the translation process, with an overall weighted Kappa value of 0.9. In the third round, eight new items were designed and consensual, obtaining a weighted overall value of 0.89. The pilot study sample was made up of 445 subjects, of which 60.3% were women with a mean age of 46.2 years. The final version consisted of 16 items, 2 factors, and a Cronbach’s alpha value of 0.92. The AMICO scale was developed to assess the level of anxiety and fear of COVID-19 and proved to be valid and reliable for its use in the adult Spanish population.

A pilot study of the disposition of pilocarpine in plasma, saliva and urine after a single oral dose

1999 ◽  
Vol 8 (2) ◽  
pp. 81-83 ◽  
Author(s):  
Chantana Aromdee ◽  
Martin M Ferguson ◽  
Robin Ledger ◽  
Justin Wall
Keyword(s):  
Pilot Study ◽  
Oral Dose ◽  
Single Oral Dose

A Rapid (48 hours) Thyroid Suppression Test using a Single Oral Dose of 100 of Triiodothyronine

1973 ◽  
Vol 12 (03) ◽  
pp. 218-224
Author(s):  
Elli Lakka - Papadodima ◽  
Constantin Ntalles ◽  
Denis Ikkos
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Suppression Test

Des mesurages répétés de la fixation thyroïdienne de 10 minutes du 132I injecté intraveineusement on été effectués sur 55 malades euthyroïdiens sans et avec goitre et sur 16 malades hyperthyreoïdiens par 4 jours consécutifs. Immédiatement après le premier mesurage tous les malades recevaient une dose unique oral de 100 μg de Triiodothyronine (T3). Les valeurs de fixation 24, 48 et 72 heures après le T3 (moyen ± déviation standard) étaient de 75 ± 1,7, 64 ± 1,8, et 67 ± 1,9 dans le groupe euthyroïdien et le 106 ± 2,6, 104 ± 2,2 et 108 ± 4,0 dans le groupe hyperthyroïdien, exprimés en pourcentage du groupe controle. 48 heures après T3 tous les personnes euthyroïdiens, sauf une, avaient des valeurs en dessous de 88% tandis que la valeur la plus basse des personnes hyperthyroïdiens ce jour était de 93%. La séparation des valeurs 48 heures des deux groupes était complète après avoir respecté l’influence de la première fixation sur la valeur 48 heures. On peut donc supposer q’un test thyroïdien de suppression utilisable en clinique peut-être effectué en 48 heures après une administration oral de 100 μg de T3 et mesurage de la fixation 10 minutes après l’injection du radioisotope.

Effect of Aspirin on the Thrombelastogram of Human Blood

1973 ◽  
Vol 30 (03) ◽  
pp. 494-498 ◽  
Author(s):  
G de Gaetano ◽  
J Vermylen
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Platelet Function ◽  
Human Blood ◽  
Platelet Rich Plasma ◽  
Plasma Samples ◽  
Release Reaction ◽  
Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

1970 ◽  
Vol 31 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Paul D. Altland ◽  
Benjamin Highman ◽  
Milton G. Parker ◽  
Michael P. Dieter
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Serum Enzyme ◽  
Tissue Changes

Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women

1983 ◽  
Vol 103 (3) ◽  
pp. 309-314 ◽  
Author(s):  
G. Rosadini ◽  
P. Masturzo ◽  
G. Rodriguez ◽  
G. Murialdo ◽  
V. Montano ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Power Analysis ◽  
Sleep Pattern ◽  
Absolute Power ◽  
Normal Women

Abstract. The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.

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