scholarly journals Effects of Non-Surgical Periodontal Treatment on Reactive Oxygen Metabolites and Glycemic Control in Diabetic Patients with Chronic Periodontitis

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1056
Author(s):  
Simone Marconcini ◽  
Enrica Giammarinaro ◽  
Saverio Cosola ◽  
Giacomo Oldoini ◽  
Annamaria Genovesi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glycemic Control ◽  
Systemic Inflammation ◽  
Glycated Hemoglobin ◽  
Reactive Oxygen ◽  
Periodontal Treatment ◽  
Diabetic Patients ◽  
Reactive Oxygen Metabolites ◽  
Periodontal Infection ◽  
Oxygen Metabolites

Background: Periodontal infection may contribute to poor glycemic control and systemic inflammation in diabetic patients. The aim of the present study is to evaluate the efficacy of non-surgical periodontal treatment in diabetic patients by measuring oxidative stress outcomes. Methods: Sixty diabetic patients with periodontitis were enrolled, treated with scaling and full-mouth disinfection, and randomly prescribed chlorhexidine mouthwash, antioxidant mouthwash, or ozone therapy. Reactive oxygen metabolites (ROMs), periodontal parameters, and glycated hemoglobin were measured at baseline and then at 1, 3, and 6 months after. Results: At baseline, all patients presented with pathologic levels of plasmatic ROM (388 ± 21.36 U CARR), higher than the normal population. Probing depth, plaque index, and bleeding on probing values showed significant clinical improvements after treatment, accompanied by significant reductions of plasma ROM levels (p < 0.05). At the 6-month evaluation, the mean ROM relapsed to 332 ± 31.76 U CARR. Glycated hemoglobin decreased significantly (∆ = −0.52 units) after treatment. Both the test groups showed longer-lasting improvements of periodontal parameters. Conclusion: In diabetic patients, periodontal treatment was effective at reducing plasma ROM, which is an indicator of systemic oxidative stress and inflammation. The treatment of periodontal infection might facilitate glycemic control and decrease systemic inflammation.

scholarly journals Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0233550
Author(s):  
Masahito Morimoto ◽  
Toshiaki Hashimoto ◽  
Yoshimi Tsuda ◽  
Tadanori Nakatsu ◽  
Taisuke Kitaoka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorder ◽  
Reactive Oxygen ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Antioxidant Potential ◽  
Reactive Oxygen Metabolites ◽  
Oxygen Metabolites

scholarly journals Antioxidant Vitamins Reduce Oxidative Stress and Ventricular Remodeling in Patients with Acute Myocardial Infarction

2005 ◽  
Vol 18 (3) ◽  
pp. 487-496 ◽  
Author(s):  
C. Gasparetto ◽  
A. Malinverno ◽  
D. Culacciati ◽  
D. Gritt ◽  
P.G. Prosperini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Reactive Oxygen ◽  
Total Antioxidant Status ◽  
Left Ventricular ◽  
Antioxidant Vitamins ◽  
Reactive Oxygen Metabolites ◽  
Oxygen Metabolites

We analyzed soluble vascular adhesion molecules (sVCAM-1), reactive oxygen metabolites (ROMs) level, total antioxidant status (TAS) and telediastolic left ventricular volume (TLW) in patients with myocardial infarction undergoing reperfusion therapy and treated with antioxidant vitamins (AT) or placebo (P) before and for 1 month after reperfusion. After reperfusion, sVCAM-1 serum concentration, reactive oxygen metabolites level, and TLW were significantly higher in patients treated with placebo than in those treated with antioxidant vitamins, while TAS was significantly higher in patients treated with antioxidant supplementation. We observed that 48 hours after reperfusion sVCAM-1 (P) vs sVCAM −1(AT) was 2.03±0.5 vs 1.63±0.7 μg/ml with p<0.01; ROMs (P) vs ROMs (AT) were 335.60±35.80 vs 307.50±47.10 U.CARR with p<0.05; TAS (P) vs TAS (AT) was 526.47±44.24 vs 737.65±51.15 μmol/l with p<0.01; 1 week after reperfusion TLW (P) vs TLW (AT) was 125.12±29.80 vs 119.40±29.40 ml with p<0.05; 1 month after reperfusion TLW (P) vs TLW (AV) was 132.00±33.50 vs 123.40±21.60 ml with p<0.05. In the first period after infarction, vitamin treatment improves the antioxidant system and reduces oxidative stress, inflammatory process and left ventricular remodeling.

Reactive Oxygen Metabolites (ROMs) as an Index of Oxidative Stress in Obstructive Sleep Apnea Patients

2003 ◽  
Vol 7 (3) ◽  
pp. 105-109 ◽  
Author(s):  
Kostas Christou ◽  
Nikolaos Markoulis ◽  
Anargyros N. Moulas ◽  
Chaido Pastaka ◽  
Kostantinos I. Gourgoulianis
Keyword(s):  
Oxidative Stress ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Reactive Oxygen ◽  
Reactive Oxygen Metabolites ◽  
Obstructive Sleep ◽  
Oxygen Metabolites

scholarly journals Serum Reactive Oxygen Metabolite Levels Are Associated with Poor Prognosis in Patients with Diffuse Large B-Cell Lymphoma

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1704-1704
Author(s):  
Shinji Ogura ◽  
Takahiro Kamiya ◽  
Kota Mizuno ◽  
Chisako Ito ◽  
Yuriko Fujita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Poor Prognosis ◽  
Cell Lymphoma ◽  
Reactive Oxygen ◽  
B Cell Lymphoma ◽  
High Serum ◽  
Reactive Oxygen Metabolites ◽  
Large B Cell Lymphoma ◽  
Oxygen Metabolites

Abstract [Introduction] Oxidative stress caused by the increased production of reactive oxygen species (ROS) or decreased efficacy of the antioxidant system is implicated in the pathogenesis of various disease entities, such as atherosclerosis, cardiovascular disease, renal failure, malignant tumors, and autoimmune diseases. Recent observations suggested that oxidative stress is closely related to all aspects of cancer. Oxidative stress markers are prognostically important in various cancers including diffuse large B-cell lymphoma (DLBCL). However, the prognostic role of serum reactive oxygen metabolites (ROMs) in DLBCL is still unknown. The objective of this study is to evaluate the role of serum ROMs in patients with DLBCL. [Methods] We enrolled 52 patients with DLBCL who were treated at our institution between 2012 and 2014. To assess oxidative stress, instead of measuring serum ROS directly, we measured serum d-ROMs (the derivatives of Reactive Oxygen Metabolites) levels. In the present study, serum d-ROMs levels were prospectively examined in 52 patients with DLBCL and 12 healthy subjects by using the Free Radical Analytical System 4 (FRAS 4, Wismerll Co. Ltd., Tokyo, Japan). The d-ROMs test has been successfully used to evaluate oxidative stress in a very large number of studies on humans and animals. The d-ROMs test essentially determines the concentration of hydroperoxides in the blood, which are substances that belong to a broad class of reactive oxygen metabolites. The d-ROMs concentration is expressed in Carratelli Units (1 CARR U = 0.08mg hydrogen peroxide/dl). The study protocol and sampling were approved by the Institutional Review Board of Yokohama Municipal Citizen's Hospital, and it was carried out in accordance with the Declaration of Helsinki. [Results] The median follow-up time was 52 months. Median age at diagnosis was 74 years (range, 39-91 years) and 60% were male. 34 patients (65%) were stage 3-4 and 33 patients (63%) were R-IPI poor risk. The serum d-ROMs levels in patients with DLBCL were significantly elevated compared with normal controls (578.9+/-194.3 vs. 286.8+/-24.2 CARR U, P<0.001). In 52 DLBCL patients, patients with high serum d-ROMs levels (≥513 CARR U) had significantly shorter overall survival (OS) than those with low serum d-ROMs levels (<513 CARR U) (5-year OS, 37.9% versus 77.7%, respectively; P<0.001) (Figure. 1). In multivariate analysis, parameters having independent adverse significance for OS were: high serum d-ROMs levels (≥513 CARR U) (p=0.002, HR 5.17), high LDH levels (p=0.008, HR 4.58), and extranodal involvement >1 (p=0.002, HR 4.57). [Conclusion] In the present study we demonstrated that elevated serum d-ROMs levels are associated with poor prognosis in patients with DLBCL. In particular, our data proved that a high serum d-ROMs level is an independent prognostic factor for survival in patients with DLBCL. These results suggest that oxidative stress may have an important role in DLBCL and may be also a useful prognostic biomarker. Since our results are based on a small-sized analysis, further large prospective studies are warranted to verify this conclusion. Disclosures No relevant conflicts of interest to declare.

Relationship Between Periodontal Condition and Plasma Reactive Oxygen Metabolites in Patients in the Maintenance Phase of Periodontal Treatment

2008 ◽  
Vol 79 (11) ◽  
pp. 2136-2142 ◽  
Author(s):  
Naofumi Tamaki ◽  
Takaaki Tomofuji ◽  
Takayuki Maruyama ◽  
Daisuke Ekuni ◽  
Reiko Yamanaka ◽  
...  
Keyword(s):  
Reactive Oxygen ◽  
Maintenance Phase ◽  
Periodontal Treatment ◽  
Reactive Oxygen Metabolites ◽  
Periodontal Condition ◽  
Oxygen Metabolites
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