scholarly journals PD030: Effects of non-surgical periodontal treatment on reactive oxygen metabolites and glycemic control in diabetic patients with chronic periodontitis

2018 ◽  
Vol 45 ◽  
pp. 50-51
Keyword(s):  
Glycemic Control ◽  
Chronic Periodontitis ◽  
Reactive Oxygen ◽  
Periodontal Treatment ◽  
Diabetic Patients ◽  
Reactive Oxygen Metabolites ◽  
Oxygen Metabolites

scholarly journals Effects of Non-Surgical Periodontal Treatment on Reactive Oxygen Metabolites and Glycemic Control in Diabetic Patients with Chronic Periodontitis

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1056
Author(s):  
Simone Marconcini ◽  
Enrica Giammarinaro ◽  
Saverio Cosola ◽  
Giacomo Oldoini ◽  
Annamaria Genovesi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glycemic Control ◽  
Systemic Inflammation ◽  
Glycated Hemoglobin ◽  
Reactive Oxygen ◽  
Periodontal Treatment ◽  
Diabetic Patients ◽  
Reactive Oxygen Metabolites ◽  
Periodontal Infection ◽  
Oxygen Metabolites

Background: Periodontal infection may contribute to poor glycemic control and systemic inflammation in diabetic patients. The aim of the present study is to evaluate the efficacy of non-surgical periodontal treatment in diabetic patients by measuring oxidative stress outcomes. Methods: Sixty diabetic patients with periodontitis were enrolled, treated with scaling and full-mouth disinfection, and randomly prescribed chlorhexidine mouthwash, antioxidant mouthwash, or ozone therapy. Reactive oxygen metabolites (ROMs), periodontal parameters, and glycated hemoglobin were measured at baseline and then at 1, 3, and 6 months after. Results: At baseline, all patients presented with pathologic levels of plasmatic ROM (388 ± 21.36 U CARR), higher than the normal population. Probing depth, plaque index, and bleeding on probing values showed significant clinical improvements after treatment, accompanied by significant reductions of plasma ROM levels (p < 0.05). At the 6-month evaluation, the mean ROM relapsed to 332 ± 31.76 U CARR. Glycated hemoglobin decreased significantly (∆ = −0.52 units) after treatment. Both the test groups showed longer-lasting improvements of periodontal parameters. Conclusion: In diabetic patients, periodontal treatment was effective at reducing plasma ROM, which is an indicator of systemic oxidative stress and inflammation. The treatment of periodontal infection might facilitate glycemic control and decrease systemic inflammation.

Short-Term Effects of Non-Surgical Periodontal Treatment on Plasma Level of Reactive Oxygen Metabolites in Patients With Chronic Periodontitis

2009 ◽  
Vol 80 (6) ◽  
pp. 901-906 ◽  
Author(s):  
Naofumi Tamaki ◽  
Takaaki Tomofuji ◽  
Daisuke Ekuni ◽  
Reiko Yamanaka ◽  
Tatsuo Yamamoto ◽  
...  
Keyword(s):  
Plasma Level ◽  
Chronic Periodontitis ◽  
Reactive Oxygen ◽  
Periodontal Treatment ◽  
Reactive Oxygen Metabolites ◽  
Short Term ◽  
Oxygen Metabolites ◽  
Short Term Effects

scholarly journals Effects of Non-Surgical Periodontal Therapy on Plasma Level of Reactive Oxygen Metabolites and Glycemic Status in Type-2 Diabetic Patients with Chronic Periodontitis

2017 ◽  
Vol 14 (1) ◽  
pp. 357-365 ◽  
Author(s):  
S. Gopalakrishnan ◽  
T. Ramakrishnan ◽  
P. Harinath ◽  
Joyson Moses ◽  
V. Shankarram ◽  
...  
Keyword(s):  
Plasma Level ◽  
Chronic Periodontitis ◽  
Reactive Oxygen ◽  
Diabetic Patients ◽  
Reactive Oxygen Metabolites ◽  
Glycemic Status ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic ◽  
Oxygen Metabolites

scholarly journals Prevalence of Reactive Oxygen Metabolites Levels in Chronic Periodontitis with Diabetic Mellitus and Chronic Periodontitis Patients in GCF, Plasma and Saliva: A Biochemical Study

2015 ◽  
Vol 8 (2) ◽  
pp. 705-710
Author(s):  
UMA SUDHAKAR ◽  
T. RAMAKRISHNAN ◽  
A. REKHA ◽  
J. MEENA ◽  
H. TAMIZHCHELVAN ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Biochemical Study ◽  
Reactive Oxygen ◽  
Reactive Oxygen Metabolites ◽  
Diabetic Mellitus ◽  
Oxygen Metabolites

Relationship Between Periodontal Condition and Plasma Reactive Oxygen Metabolites in Patients in the Maintenance Phase of Periodontal Treatment

2008 ◽  
Vol 79 (11) ◽  
pp. 2136-2142 ◽  
Author(s):  
Naofumi Tamaki ◽  
Takaaki Tomofuji ◽  
Takayuki Maruyama ◽  
Daisuke Ekuni ◽  
Reiko Yamanaka ◽  
...  
Keyword(s):  
Reactive Oxygen ◽  
Maintenance Phase ◽  
Periodontal Treatment ◽  
Reactive Oxygen Metabolites ◽  
Periodontal Condition ◽  
Oxygen Metabolites

scholarly journals Generation of Reactive Oxygen Metabolites by the Varicose Vein Wall

2002 ◽  
Vol 23 (6) ◽  
pp. 550-555 ◽  
Author(s):  
J. Glowinski ◽  
S. Glowinski
Keyword(s):  
Varicose Vein ◽  
Reactive Oxygen ◽  
Reactive Oxygen Metabolites ◽  
Vein Wall ◽  
Oxygen Metabolites

Generation of reactive oxygen metabolites by phagocytosing endothelial cells

1988 ◽  
Vol 72 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Peter Görög ◽  
Jeremy D. Pearson ◽  
Vijay V. Kakkar
Keyword(s):  
Endothelial Cells ◽  
Reactive Oxygen ◽  
Reactive Oxygen Metabolites ◽  
Oxygen Metabolites

Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria

1987 ◽  
Vol 253 (4) ◽  
pp. C495-C499 ◽  
Author(s):  
P. D. Walker ◽  
S. V. Shah
Keyword(s):  
Hydrogen Peroxide ◽  
Mitochondrial Respiration ◽  
Critical Role ◽  
Reactive Oxygen ◽  
Reactive Oxygen Metabolites ◽  
Enhanced Production ◽  
Production Of Hydrogen ◽  
Hydrogen Peroxide Generation ◽  
Dose Dependent ◽  
Oxygen Metabolites

Agents that affect mitochondrial respiration have been shown to enhance the generation of reactive oxygen metabolites. On the basis of the well-demonstrated ability of gentamicin to alter mitochondrial respiration (stimulation of state 4 and inhibition of state 3), it was postulated that gentamicin may enhance the generation of reactive oxygen metabolites by renal cortical mitochondria. The aim of this study was to examine the effect of gentamicin on the production of hydrogen peroxide (measured as the decrease in scopoletin fluorescence) in rat renal cortical mitochondria. The hydrogen peroxide generation by mitochondria was enhanced from 0.17 +/- 0.02 nmol . mg-1 . min-1 (n = 14) in the absence of gentamicin to 6.21 +/- 0.67 nmol . mg-1 . min-1 (n = 14) in the presence of 4 mM gentamicin. This response was dose dependent with a significant increase observed at even the lowest concentration of gentamicin tested, 0.01 mM. Production of hydrogen peroxide was not increased when gentamicin was added to incubation media in which mitochondria or substrate was omitted or heat-inactivated mitochondria were used. The gentamicin-induced change in fluorescence was completely inhibited by catalase (but not by heat-inactivated catalase), indicating that the decrease in fluorescence was due to hydrogen peroxide. Thus this study demonstrates that gentamicin enhances the production of hydrogen peroxide by mitochondria. Because of their well-documented cytotoxicity, reactive oxygen metabolites may play a critical role in gentamicin nephrotoxicity.

Sign in / Sign up

Export Citation Format

Share Document