scholarly journals Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane Films

2019 ◽  
Vol 6 (3) ◽  
pp. 69 ◽  
Author(s):  
Aaron C. Wilson ◽  
Shih-Feng Chou ◽  
Roberto Lozano ◽  
Jonathan Y. Chen ◽  
Pierre F. Neuenschwander
Keyword(s):  
Polymeric Materials ◽  
Fold Increase ◽  
Human Blood Plasma ◽  
Enzymatic Reactions ◽  
Structure Property ◽  
Weight Changes ◽  
Implantable Medical Devices ◽  
Structure Property Relationships ◽  
Elongation To Failure

Hemocompatibility remains a challenge for injectable and/or implantable medical devices, and thromboresistant coatings appear to be one of the most attractive methods to down-regulate the unwanted enzymatic reactions that promote the formation of blood clots. Among all polymeric materials, polyurethanes (PUs) are a class of biomaterials with excellent biocompatibility and bioinertness that are suitable for the use of thromboresistant coatings. In this work, we investigated the thermal and physico-mechanical behaviors of ester-based and ether-based PU films for potential uses in thromboresistant coatings. Our results show that poly(ester urethane) and poly(ether urethane) films exhibited characteristic peaks corresponding to their molecular configurations. Thermal characterizations suggest a two-step decomposition process for the poly(ether urethane) films. Physico-mechanical characterizations show that the surfaces of the PU films were hydrophobic with minimal weight changes in physiological conditions over 14 days. All PU films exhibited high tensile strength and large elongation to failure, attributed to their semi-crystalline structure. Finally, the in vitro clotting assays confirmed their thromboresistance with approximately 1000-fold increase in contact time with human blood plasma as compared to the glass control. Our work correlates the structure-property relationships of PU films with their excellent thromboresistant ability.

Combined TEM/SEI of polymer membranes

1984 ◽  
Vol 42 ◽  
pp. 386-387
Author(s):  
L. C. Sawyer
Keyword(s):  
Three Dimensional ◽  
Polymer Membranes ◽  
Industrial Process ◽  
Polymeric Materials ◽  
Structure Property ◽  
Shape Distribution ◽  
Structure Property Relationships ◽  
Wide Range ◽  
Fundamental Understanding ◽  
Potential Applications

Structure-property relationships are important in the process optimization and fundamental understanding of many polymeric materials, including membranes. Polymer membranes are currently being used for separation, concentration or purification in a wide range of industrial process applications. The process used to manufacture the membrane, and the polymer type, determines the morphology, which influences the membrane transport properties and potential applications. The morphology includes: pore size, shape, distribution and their overall three dimensional arrangement. Microscopical methods are needed to image the structures formed by the various processes, in order to systematically study changes in variables for specific applications.

Nonclassical crystallization in vivo et in vitro (I): Process-structure-property relationships of nanogranular biominerals

2016 ◽  
Vol 196 (2) ◽  
pp. 244-259 ◽  
Author(s):  
Stephan E. Wolf ◽  
Corinna F. Böhm ◽  
Joe Harris ◽  
Benedikt Demmert ◽  
Dorrit E. Jacob ◽  
...  
Keyword(s):  
Structure Property ◽  
Structure Property Relationships ◽  
Process Structure

Characterization of Metal-Oxide Nanoparticles: Synthesis and Dispersion in Polymeric Coatings

2002 ◽  
Vol 740 ◽  
Author(s):  
Li-Piin Sung ◽  
Stephanie Scierka ◽  
Mana Baghai-Anaraki ◽  
Derek L. Ho
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Sol Gel ◽  
Polymeric Materials ◽  
Oxide Nanoparticles ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Yield Information ◽  
Sol Gel Synthesis

ABSTRACTMetal-oxide nanoparticles can be used to optimize UV absorption and to enhance the stiffness, toughness, and probably the service life of polymeric materials. Characterization of the nano- and microstructure dispersion of particles is necessary to optimize the structure-property relationships. Characterizations of both TiO2 particles dispersed in an acrylic-urethane matrix and TiO2 nanostructured films obtained through sol-gel synthesis are discussed. Experimental methods include microscopy (confocal, AFM) and small angle neutron scattering (SANS). Results from SANS experiments, which yield information about the cluster size of the nano-TiO2 particles and the spatial dispersion in various nanoparticle/polymer samples are presented and compared to the results of microscopy studies.

scholarly journals Systematic and Quantitative Structure-Property Relationships of Polymeric Medical Nanomaterials: From Systematic Synthesis and Characterization to Computer Modeling and Nano-Bio Interaction and Toxicity

2020 ◽  
Author(s):  
kegang Liu ◽  
xueya wang ◽  
Xiaochun Li-Blatter ◽  
Marc P. Wolf ◽  
Patrick Hunziker
Keyword(s):  
Computer Modeling ◽  
Polymeric Micelles ◽  
Physicochemical Characterization ◽  
Medical Application ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Quantitative Structure Property Relationships ◽  
Medical Diagnostic

<div>Nanomaterials are suitable for numerous applications in medicine. Building on their design versatility, they enable construction of novel targeted therapies, including personalized medicine. However, the freedom of design entails a multitude of parameters, which have to be optimized for application in nanomedicine. <br></div><div>Currently,nonamaterial assortment is mainly anecdotal, non-systematic and non-representative. In contrast to the mostly oligo-disciplinary nature of many publications, we here present a systematic and comprehensive multidisciplinary approach to chemical synthesis, physicochemical characterization, computer modeling, and in vitro and in vivo exploration of nanomaterials that may be suited for medical application. Specially, we design and synthesize a library of amphiphilic oxazoline/siloxane block co-polymers with varying chain lengths and different end groups. In this regard, the computer modeling of the current polymer library is contributing to further optimization of these nanomaterials in a fast and reliable, and efficient way. In conclusion, these outstandingly versatile and non-toxic polymers can be synthesized rapidly and easily and self-assemble to polymeric micelles in aqueous solutions, thus rendering them amenable for numerous medical diagnostic and therapeutic applications <br></div><div></div>

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