scholarly journals Systematic and Quantitative Structure-Property Relationships of Polymeric Medical Nanomaterials: From Systematic Synthesis and Characterization to Computer Modeling and Nano-Bio Interaction and Toxicity

2020 ◽  
Author(s):  
kegang Liu ◽  
xueya wang ◽  
Xiaochun Li-Blatter ◽  
Marc P. Wolf ◽  
Patrick Hunziker
Keyword(s):  
Computer Modeling ◽  
Polymeric Micelles ◽  
Physicochemical Characterization ◽  
Medical Application ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Quantitative Structure Property Relationships ◽  
Medical Diagnostic

<div>Nanomaterials are suitable for numerous applications in medicine. Building on their design versatility, they enable construction of novel targeted therapies, including personalized medicine. However, the freedom of design entails a multitude of parameters, which have to be optimized for application in nanomedicine. <br></div><div>Currently,nonamaterial assortment is mainly anecdotal, non-systematic and non-representative. In contrast to the mostly oligo-disciplinary nature of many publications, we here present a systematic and comprehensive multidisciplinary approach to chemical synthesis, physicochemical characterization, computer modeling, and in vitro and in vivo exploration of nanomaterials that may be suited for medical application. Specially, we design and synthesize a library of amphiphilic oxazoline/siloxane block co-polymers with varying chain lengths and different end groups. In this regard, the computer modeling of the current polymer library is contributing to further optimization of these nanomaterials in a fast and reliable, and efficient way. In conclusion, these outstandingly versatile and non-toxic polymers can be synthesized rapidly and easily and self-assemble to polymeric micelles in aqueous solutions, thus rendering them amenable for numerous medical diagnostic and therapeutic applications <br></div><div></div>

scholarly journals Systematic and Quantitative Structure-Property Relationships of Polymeric Medical Nanomaterials: From Systematic Synthesis and Characterization to Computer Modeling and Nano-Bio Interaction and Toxicity

2020 ◽  
Author(s):  
kegang Liu ◽  
xueya wang ◽  
Xiaochun Li-Blatter ◽  
Marc P. Wolf ◽  
Patrick Hunziker
Keyword(s):  
Computer Modeling ◽  
Polymeric Micelles ◽  
Physicochemical Characterization ◽  
Medical Application ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Quantitative Structure Property Relationships ◽  
Medical Diagnostic

<div>Nanomaterials are suitable for numerous applications in medicine. Building on their design versatility, they enable construction of novel targeted therapies, including personalized medicine. However, the freedom of design entails a multitude of parameters, which have to be optimized for application in nanomedicine. <br></div><div>Currently,nonamaterial assortment is mainly anecdotal, non-systematic and non-representative. In contrast to the mostly oligo-disciplinary nature of many publications, we here present a systematic and comprehensive multidisciplinary approach to chemical synthesis, physicochemical characterization, computer modeling, and in vitro and in vivo exploration of nanomaterials that may be suited for medical application. Specially, we design and synthesize a library of amphiphilic oxazoline/siloxane block co-polymers with varying chain lengths and different end groups. In this regard, the computer modeling of the current polymer library is contributing to further optimization of these nanomaterials in a fast and reliable, and efficient way. In conclusion, these outstandingly versatile and non-toxic polymers can be synthesized rapidly and easily and self-assemble to polymeric micelles in aqueous solutions, thus rendering them amenable for numerous medical diagnostic and therapeutic applications <br></div><div></div>

Nonclassical crystallization in vivo et in vitro (I): Process-structure-property relationships of nanogranular biominerals

2016 ◽  
Vol 196 (2) ◽  
pp. 244-259 ◽  
Author(s):  
Stephan E. Wolf ◽  
Corinna F. Böhm ◽  
Joe Harris ◽  
Benedikt Demmert ◽  
Dorrit E. Jacob ◽  
...  
Keyword(s):  
Structure Property ◽  
Structure Property Relationships ◽  
Process Structure

scholarly journals State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products

2020 ◽  
Vol 4 ◽  
pp. 239784732097975
Author(s):  
Stéphanie Boué ◽  
Didier Goedertier ◽  
Julia Hoeng ◽  
Anita Iskandar ◽  
Arkadiusz K Kuczaj ◽  
...  
Keyword(s):  
Ad Hoc ◽  
State Of The Art ◽  
Physicochemical Characterization ◽  
Objective Evaluation ◽  
Vapor Generation ◽  
Characterization Methods ◽  
Clinical Exposure ◽  
Aerosol Generation

E-vapor products (EVP) have become popular alternatives for cigarette smokers who would otherwise continue to smoke. EVP research is challenging and complex, mostly because of the numerous and rapidly evolving technologies and designs as well as the multiplicity of e-liquid flavors and solvents available on the market. There is an urgent need to standardize all stages of EVP assessment, from the production of a reference product to e-vapor generation methods and from physicochemical characterization methods to nonclinical and clinical exposure studies. The objective of this review is to provide a detailed description of selected experimental setups and methods for EVP aerosol generation and collection and exposure systems for their in vitro and in vivo assessment. The focus is on the specificities of the product that constitute challenges and require development of ad hoc assessment frameworks, equipment, and methods. In so doing, this review aims to support further studies, objective evaluation, comparison, and verification of existing evidence, and, ultimately, formulation of standardized methods for testing EVPs.

scholarly journals Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4127
Author(s):  
Aline de Cristo Soares Alves ◽  
Franciele Aline Bruinsmann ◽  
Silvia Stanisçuaski Guterres ◽  
Adriana Raffin Pohlmann
Keyword(s):  
Monoclonal Antibody ◽  
Physicochemical Characterization ◽  
Vascular Endothelial ◽  
Organic Nanoparticles ◽  
Humanized Monoclonal Antibody ◽  
Angiogenesis Process ◽  
Endothelial Growth Factor ◽  
Drug Pharmacokinetics

Bevacizumab (BCZ) is a recombinant humanized monoclonal antibody against the vascular endothelial growth factor, which is involved in the angiogenesis process. Pathologic angiogenesis is observed in several diseases including ophthalmic disorders and cancer. The multiple administrations of BCZ can cause adverse effects. In this way, the development of controlled release systems for BCZ delivery can promote the modification of drug pharmacokinetics and, consequently, decrease the dose, toxicity, and cost due to improved efficacy. This review highlights BCZ formulated in organic nanoparticles providing an overview of the physicochemical characterization and in vitro and in vivo biological evaluations. Moreover, the main advantages and limitations of the different approaches are discussed. Despite difficulties in working with antibodies, those nanocarriers provided advantages in BCZ protection against degradation guaranteeing bioactivity maintenance.

scholarly journals The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance In Vitro While Reducing Its Toxicity In Vivo

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 186
Author(s):  
Maria Natalia Calienni ◽  
Daniela Maza Vega ◽  
C. Facundo Temprana ◽  
María Cecilia Izquierdo ◽  
David E. Ybarra ◽  
...  
Keyword(s):  
Side Effects ◽  
Water Solubility ◽  
Polymeric Micelles ◽  
Skin Penetration ◽  
Distribution Volume ◽  
And Performance ◽  
Oral Doses ◽  
Advanced Basal Cell Carcinoma

Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the in vitro and in vivo toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical application. These findings may be also useful for the consideration of topical delivery of other drugs with a low water solubility.

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