scholarly journals Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 868
Author(s):  
Jiayang Zhang ◽  
Ruoyu Sun ◽  
Tingting Jiang ◽  
Guangrui Yang ◽  
Lihong Chen

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.

2011 ◽  
Vol 147 ◽  
pp. S90
Author(s):  
S. Okutucu ◽  
U.N. Karakulak ◽  
G. Kabakci ◽  
E. Demiri ◽  
S.G. Fatihoglu ◽  
...  

2020 ◽  
Vol 74 (2) ◽  
pp. 9-13
Author(s):  
M.Ya. Ledyaev ◽  
◽  
A.M. Ledyaeva ◽  

The review is about modern conceptions of vascular tone regulation and its influence on circadian blood pressure rhythm.


Endocrinology ◽  
2021 ◽  
Author(s):  
Gregory P Westcott ◽  
Evan D Rosen

Abstract Adipose tissue, once thought to be an inert receptacle for energy storage, is now recognized as a complex tissue with multiple resident cell populations which actively collaborate in response to diverse local and systemic metabolic, thermal, and inflammatory signals. A key participant in adipose tissue homeostasis that has only recently captured broad scientific attention is the lymphatic vasculature. The lymphatic system’s role in lipid trafficking and mediating inflammation makes it a natural partner in the regulation of adipose tissue, and evidence supporting a bidirectional relationship between lymphatics and adipose tissue has accumulated in recent years. Obesity is now understood to impair lymphatic function, while altered lymphatic function results in aberrant adipose tissue deposition, though the molecular mechanisms governing these phenomena have yet to be fully elucidated. We will review our current understanding of the relationship between adipose tissue and the lymphatic system here, focusing on known mechanisms of lymphatic-adipose cross-talk.


2007 ◽  
Vol 293 (3) ◽  
pp. F655-F659 ◽  
Author(s):  
Rajiv Agarwal

Circadian blood pressure changes are blunted in patients with chronic kidney disease (CKD). Proteinuria is the most important correlate of hypertension in CKD. However, little is known about the influence of circadian blood pressure changes and variation in protein excretion rate. Furthermore, the impact of blood pressure components, e.g., mean arterial pressure and pulse pressure, on proteinuria has not been evaluated. To analyze the relationship of circadian changes in blood pressure on urinary protein excretion patterns, glomerular filtration rate was measured with iothalamate clearance and 24-h ambulatory blood pressure with SpaceLabs 90207 monitor in 22 patients with CKD. It was found that hourly protein excretion rates were 31% higher during the night. Excretion results of sodium, potassium, chloride, urea, and creatinine were also between 30 and 40% higher at night. Systolic, mean arterial, and pulse pressures but not diastolic pressure were related to daytime protein excretion rate. At night, the relationship of systolic, diastolic, and mean arterial pressures was significantly lower and essentially flat with respect to protein excretion rate, but the relationship of pulse pressure and proteinuria was not different from that seen during the day. Circadian variation in blood pressure did not impact circadian sodium excretion rate. In conclusion, these data suggest that patients with CKD have patterns of proteinuria that share different relationships with blood pressure components depending on the awake-sleep state. Pulse pressure is related to proteinuria independent of the awake-sleep state. Reducing mean arterial pressure during the day and pulse pressure during the day or night may be effective antiproteinuric strategies.


Author(s):  

A Chronobiology, a science that studies the temporal organization of living beings, establishes molecular mechanisms that explain the rhythmicity observed in organisms. Between the rhythmic variations observed is blood pressure, which shows a morning rise and nocturnal dipping, the latter being important in predicting cardiovascular risk. The individuals can also be chronophenotypically classified according to their daily preferences, in morningness-eveningness. Objectives: To verify the hypothesis of a relationship between the morning chronotype and the nondipper night pressure profile. Methodology: Descriptive cross-sectional study, with the realization of the noninvasive ambulatory monitoring of blood pressure to obtain the pressure curve and answer the questionnaire of Ostberg's personal preferences. Results: The survey included twenty participants, from nine were classified as dipper and eleven as nondipper; in addition, twelve were classified as morning and eight as non-morning. The hypothesis test revealed statistical significance in the relationship between morning chronotype and nocturnal non-descent pattern of blood pressure (p = 0.0493), confirming the initial hypothesis, which implies greater risk cardiovascular to this population. Conclusion: The relationship between morning and morning non-nocturnal blood pressure decrease, and further studies are needed to better characterizing this relationship.


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