scholarly journals HMGB1-TIM3-HO1: A New Pathway of Inflammation in Skin of SARS-CoV-2 Patients? A Retrospective Pilot Study

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1219
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Gerolamo Cicco ◽  
Vincenza Sara Scarcella ◽  
...  
Keyword(s):  
Pilot Study ◽  
Skin Biopsy ◽  
T Lymphocyte ◽  
Heme Oxygenase 1 ◽  
Lymphocyte Population ◽  
Upper Airways ◽  
Reliable Methods ◽  
Hematoxylin Eosin ◽  
Entire Planet ◽  
Skin Samples

The SARS-CoV-2 pandemic has completely disrupted the health systems of the entire planet. From the earliest months, it became increasingly clear that in addition to affecting the upper airways and lungs, there were other organs that could be affected. Among these, the skin became a real “sentinel signal” to be able to even suspect COVID-19. Background: this study deals with a little-explored issue for now: the study of skin immunopathology in SARS-CoV-2 positive subjects ascertained using the most reliable methods available. Methods: we used skin biopsy samples from SARS-CoV-2 positive and negative patients, studying morphology (Hematoxylin-Eosin), T lymphocyte population (CD4 and CD8), three markers such as HMGB-1, TIM-3 and HO-1 by immunohistochemistry. Results: although the presence of the CD4 and CD8 T population did not differ statistically significantly, we found greater activation and release of HMGB-1 in skin samples from SARS-CoV-2 positive patients, greater immunolabeling for TIM-3 at the level of CD4 and CD8 and a reduced expression of Heme oxygenase 1. Conclusions: these results support the possibility that there is immune deregulation in SARS-CoV-2 positive patients who develop skin manifestations of various kinds.

Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

The Lancet ◽  
1991 ◽  
Vol 337 (8733) ◽  
pp. 76-77 ◽  
Author(s):  
T. Hattori ◽  
N. Asou ◽  
H. Suzushima ◽  
K. Takatsuki ◽  
K. Tanaka ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Population

scholarly journals cDNA Array Analysis Identifies Thymic LCK as Upregulated in Moderate Murine Zinc Deficiency before T-Lymphocyte Population Changes

2001 ◽  
Vol 131 (12) ◽  
pp. 3189-3196 ◽  
Author(s):  
J. Bernadette Moore ◽  
Raymond K. Blanchard ◽  
Wayne T. McCormack ◽  
Robert J. Cousins
Keyword(s):  
Zinc Deficiency ◽  
T Lymphocyte ◽  
Cdna Array ◽  
Lymphocyte Population ◽  
Population Changes ◽  
Array Analysis

T Lymphocyte Population Dynamics and Function Following a Primary Bovine Herpesvirus Type-1 Infection

1987 ◽  
Vol 1 (4) ◽  
pp. 287-304 ◽  
Author(s):  
PHILIP J. GRIEBEL ◽  
LOUIS QUALTIERE ◽  
WILLIAM C. DAVIS ◽  
ADRIAN GEE ◽  
HELLE BIELEFELDT OHMANN ◽  
...  
Keyword(s):  
Population Dynamics ◽  
T Lymphocyte ◽  
Bovine Herpesvirus ◽  
Lymphocyte Population ◽  
Herpesvirus Type ◽  
Bovine Herpesvirus Type 1 ◽  
Dynamics And Function ◽  
And Function

scholarly journals An Investigation into the Impact of a Glutaminase Inhibitor, Compound 968, on Nrf2 Signaling

2021 ◽  
Vol 1 (1) ◽  
pp. 41-47
Author(s):  
Wei Lei ◽  
Valentin M. Kliebe ◽  
Xin Chen
Keyword(s):  
Molecular Docking ◽  
Pilot Study ◽  
Neurodegenerative Diseases ◽  
Heme Oxygenase ◽  
Pathological Process ◽  
Luciferase Assay ◽  
Heme Oxygenase 1 ◽  
Nrf2 Activation ◽  
Energy Synthesis ◽  
The Impact

Glutaminase is a critical enzyme that catalyzes the process of glutaminolysis for energy synthesis. Meanwhile, glutaminase also contributes to the pathological process of various diseases, such as cancer, neurodegenerative diseases, and inflammation. This leads to the discovery of glutaminase inhibitors for therapeutical uses. However, the mechanisms of the beneficial therapeutical effect of glutaminase inhibitors are still unclear. This pilot study aimed to determine the impact of a well-characterized glutaminase inhibitor, compound 968 (C968), on Nrf2 signaling. We performed molecular docking, luciferase assay, and quantitative PCR to determine the activation of Nrf2 and the expression of several Nrf2-related genes. These experiments found that C968 induced the Nrf2 activation and promoted the expression of Nrf2, heme oxygenase-1 (HO-1), and NAD(P)H Quinone Dehydrogenase-1 (NQO-1). All findings provide evidence that Nrf2 activation could be one of the mechanisms contributing to the therapeutical activity of C968, but more studies are warranted to further confirm this mechanism.

A prospective pilot study of the T‐lymphocyte response to fine particulate matter exposure

2020 ◽  
Vol 40 (5) ◽  
pp. 619-630
Author(s):  
Margueritta Al Zallouha ◽  
Yann Landkocz ◽  
Clémence Méausoone ◽  
Fréderic Ledoux ◽  
Fabien Visade ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Pilot Study ◽  
T Lymphocyte ◽  
Fine Particulate Matter ◽  
Lymphocyte Response ◽  
Prospective Pilot Study ◽  
Fine Particulate ◽  
Particulate Matter Exposure

Embedded Adrenal Cells Graft Reduced Local and Early Nonspecific Inflammatory Phenomena Which Follow Agarose Beads Implantation

1992 ◽  
Vol 1 (5) ◽  
pp. 349-354 ◽  
Author(s):  
Ch. Cadic ◽  
S. Vitiello ◽  
H. Gin ◽  
P.J. Neveu ◽  
B. Dupuy
Keyword(s):  
T Lymphocyte ◽  
Inflammatory Reaction ◽  
Cell Populations ◽  
Lymphocyte Population ◽  
Cellular Reaction ◽  
Adrenal Cells ◽  
Agarose Beads ◽  
Macrophage Marker ◽  
Suitable Solution ◽  
Cell Subpopulations

Microencapsulation of adrenal cells is proposed for reducing the nonspecific inflammatory reaction observed around polymer implants. This hypothesis was tested by comparing both host cellular reaction and the surrounding graft cell populations which appeared either when agarose embedded cells or when empty agarose beads were implanted. Our results showed that the fibrotic material that surrounded the implanted empty agarose microbeads was not as severe and important when adrenal cells were present. Similarly, T lymphocyte population surrounding the graft was considerably reduced together with the percentage of CD4 and CD8 positive cell subpopulations. The activation macrophage marker IaD disappeared. Our results support the hypothesis that embedded adrenal cells may be a suitable solution for reducing early inflammatory events due to microcapsules implantation.

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