The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies

Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted researchers to propose the polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) as promoters of resolution of cancer-associated inflammation. SPMs were found to inhibit the CRC-associated pro-inflammatory milieu via specific G-coupled protein receptors, although clinical data are still lacking. This review aims to summarize the state-of-the-art in this field, ultimately providing insights for the development of innovative anti-CRC therapies that promote the endogenous lipid-mediated resolution of CRC-associated inflammation.

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Nutritional Optic Neuropathies: State of the Art and Emerging Evidences

Nutrients ◽

10.3390/nu12092653 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2653

Author(s):

Matilde Roda ◽

Natalie di Geronimo ◽

Marco Pellegrini ◽

Costantino Schiavi

Keyword(s):

Bariatric Surgery ◽

Optic Neuropathy ◽

Multidisciplinary Approach ◽

State Of The Art ◽

Signs And Symptoms ◽

Therapeutic Strategies ◽

Scientific Interest ◽

Optic Nerve Atrophy ◽

Prompt Diagnosis

Nutritional optic neuropathy is a cause of bilateral, symmetrical, and progressive visual impairment with loss of central visual acuity and contrast sensitivity, dyschromatopsia, and a central or centrocecal scotoma. The clinical features are not pathognomonic, since hereditary and toxic forms share similar signs and symptoms. It is becoming increasingly common due to the widespread of bariatric surgery and strict vegetarian or vegan diets, so even the scientific interest has recently increased. In particular, recent studies have focused on possible pathogenetic mechanisms, and on novel diagnostic and therapeutic strategies in order to prevent the onset, make a prompt diagnosis and an accurate nutritional supplementation, and to avoid irreversible optic nerve atrophy. Nowadays, there is clear evidence of the role of cobalamin, folic acid, thiamine, and copper, whereas further studies are needed to define the role of niacin, riboflavin, and pyridoxine. This review aims to summarize the etiology, diagnosis, and treatment of nutritional optic neuropathy, and it is addressed not only to ophthalmologists, but to all physicians who could come in contact with a patient with a possible nutritional optic neuropathy, being a fundamental multidisciplinary approach.

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The Role of Anti-Inflammatory Drugs in Colorectal Cancer

Annual Review of Medicine ◽

10.1146/annurev-med-112211-154330 ◽

2013 ◽

Vol 64 (1) ◽

pp. 131-144 ◽

Cited By ~ 65

Author(s):

Dingzhi Wang ◽

Raymond N. DuBois

Keyword(s):

Colorectal Cancer ◽

Inflammatory Drugs ◽

Anti Inflammatory

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The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

Perioperaciina Medicina ◽

10.31636/prmd.v4i2.2 ◽

2021 ◽

Vol 4 (2) ◽

pp. 11-16

Author(s):

O Kalashnikov ◽

O Sulyma ◽

T Osadchuk ◽

V Zayets ◽

T Nizalov ◽

...

Keyword(s):

Side Effects ◽

Adverse Side Effects ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

High Level ◽

Time Of Administration ◽

Inflammatory Effect ◽

The Ideal

The authors of the article analyzed the experience of domestic and foreign experts in the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major joints. Background and Objective. To analyze the literature sources in order to determine the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major ligaments. Materials and methods. Articles in specialized scientific journals and collections, Internet resource.Results. The analysis of literature sources determined the important role of HA preparations in the supplying and functioning of the articular cartilage. Researchers are inclined to believe that the ideal HA preparation should be as close as possible to the physiological HA of the synovial fluid of the joint. The developed domestic drug Artro-Patch fully corresponds to these parameters. Conclusions. The use of modern injectable HA preparations is advisable at stages 1–3 of OA. Anti-inflammatory effect of HA preparations makes it possible to reduce the dose and time of administration of non-steroidal anti-inflammatory drugs and, as a consequence, reduce the risk of developing many adverse side effects of NSAIDs. The high level of safety of HA preparations, the absence of serious side effects during their long-term use determine their widespread use in the clinical practice of modern orthopedists.

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The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention

European Journal of Cancer ◽

10.1016/0959-8049(95)00137-8 ◽

1995 ◽

Vol 31 (7-8) ◽

pp. 1071-1076 ◽

Cited By ~ 104

Author(s):

F.M Giardiello ◽

G.J.A Offerhaus ◽

R.N DuBois

Keyword(s):

Colorectal Cancer ◽

Cancer Prevention ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Colorectal Cancer Prevention

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Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-000609 ◽

2020 ◽

Vol 8 (2) ◽

pp. e000609

Author(s):

Yungang Wang ◽

Yanxia Ding ◽

Yijun Deng ◽

Yu Zheng ◽

Shengjun Wang

Keyword(s):

Colorectal Cancer ◽

Inflammatory Bowel Disease ◽

Regulatory Network ◽

Suppressor Cells ◽

Therapeutic Strategies ◽

Heterogeneous Population ◽

Myeloid Derived Suppressor Cells ◽

Immature Myeloid Cells ◽

Inflammatory Bowel

Colitis-associated cancer (CAC) is a specific type of colorectal cancer that develops from inflammatory bowel disease (IBD). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are essential for the pathological processes of inflammation and cancer. Accumulating evidence indicates that MDSCs play different but vital roles during IBD and CAC development and impede CAC immunotherapy. New insights into the regulatory network of MDSCs in the CAC pathogenesis are opening new avenues for developing strategies to enhance the effectiveness of CAC treatment. In this review, we explore the role of MDSCs in chronic inflammation, dysplasia and CAC and summarize the potential CAC therapeutic strategies based on MDSC blockade.

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State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

Life ◽

10.3390/life10060082 ◽

2020 ◽

Vol 10 (6) ◽

pp. 82

Author(s):

Federico Mucci ◽

Donatella Marazziti ◽

Alessandra Della Vecchia ◽

Stefano Baroni ◽

Paolo Morana ◽

...

Keyword(s):

Mood Disorders ◽

State Of The Art ◽

Therapeutic Strategies ◽

Metabolic Processes ◽

Metabolic Markers ◽

Comprehensive Review ◽

Immune Systems

Mounting evidence highlights the involvement of inflammatory/immune systems and their relationships with neurotransmitters and different metabolic processes in mood disorders. Nevertheless, there is a general agreement that available findings are still inconclusive. Therefore, further investigations are required, aimed at deepening the role of possible alterations of biomarkers in the pathophysiology of mood disorders that might lead to more focused and tailored treatments. The present study is a comprehensive review on these topics that seem to represent intriguing avenues for the development of real innovative therapeutic strategies of mood disorders.

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The Contemporary Role of Resection and Ablation in Colorectal Cancer Liver Metastases

Digestive Disease Interventions ◽

10.1055/s-0040-1715816 ◽

2020 ◽

Vol 04 (03) ◽

pp. 291-302

Author(s):

Mariam F. Eskander ◽

Christopher T. Aquina ◽

Aslam Ejaz ◽

Timothy M. Pawlik

Keyword(s):

Colorectal Cancer ◽

Portal Vein ◽

Surgical Oncology ◽

Portal Vein Ligation ◽

Safe Alternative ◽

Colorectal Cancer Liver Metastases ◽

Liver Remnant ◽

New Era ◽

Ablation Therapy

AbstractAdvances in the field of surgical oncology have turned metastatic colorectal cancer of the liver from a lethal disease to a chronic disease and have ushered in a new era of multimodal therapy for this challenging illness. A better understanding of tumor behavior and more effective systemic therapy have led to the increased use of neoadjuvant therapy. Surgical resection remains the gold standard for treatment but without the size, distribution, and margin restrictions of the past. Lesions are considered resectable if they can safely be removed with tumor-free margins and a sufficient liver remnant. Minimally invasive liver resections are a safe alternative to open surgery and may offer some advantages. Techniques such as portal vein embolization, association of liver partition with portal vein ligation for staged hepatectomy, and radioembolization can be used to grow the liver remnant and allow for resection. If resection is not possible, nonresectional ablation therapy, including radiofrequency and microwave ablation, can be performed alone or in conjunction with resection. This article presents the most up-to-date literature on resection and ablation, with a discussion of current controversies and future directions.

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