scholarly journals State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders

Life ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 82
Author(s):  
Federico Mucci ◽  
Donatella Marazziti ◽  
Alessandra Della Vecchia ◽  
Stefano Baroni ◽  
Paolo Morana ◽  
...  
Keyword(s):  
Mood Disorders ◽  
State Of The Art ◽  
Therapeutic Strategies ◽  
Metabolic Processes ◽  
Metabolic Markers ◽  
Comprehensive Review ◽  
Immune Systems

Mounting evidence highlights the involvement of inflammatory/immune systems and their relationships with neurotransmitters and different metabolic processes in mood disorders. Nevertheless, there is a general agreement that available findings are still inconclusive. Therefore, further investigations are required, aimed at deepening the role of possible alterations of biomarkers in the pathophysiology of mood disorders that might lead to more focused and tailored treatments. The present study is a comprehensive review on these topics that seem to represent intriguing avenues for the development of real innovative therapeutic strategies of mood disorders.

scholarly journals Nutritional Optic Neuropathies: State of the Art and Emerging Evidences

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2653
Author(s):  
Matilde Roda ◽  
Natalie di Geronimo ◽  
Marco Pellegrini ◽  
Costantino Schiavi
Keyword(s):  
Bariatric Surgery ◽  
Optic Neuropathy ◽  
Multidisciplinary Approach ◽  
State Of The Art ◽  
Signs And Symptoms ◽  
Therapeutic Strategies ◽  
Scientific Interest ◽  
Optic Nerve Atrophy ◽  
Prompt Diagnosis

Nutritional optic neuropathy is a cause of bilateral, symmetrical, and progressive visual impairment with loss of central visual acuity and contrast sensitivity, dyschromatopsia, and a central or centrocecal scotoma. The clinical features are not pathognomonic, since hereditary and toxic forms share similar signs and symptoms. It is becoming increasingly common due to the widespread of bariatric surgery and strict vegetarian or vegan diets, so even the scientific interest has recently increased. In particular, recent studies have focused on possible pathogenetic mechanisms, and on novel diagnostic and therapeutic strategies in order to prevent the onset, make a prompt diagnosis and an accurate nutritional supplementation, and to avoid irreversible optic nerve atrophy. Nowadays, there is clear evidence of the role of cobalamin, folic acid, thiamine, and copper, whereas further studies are needed to define the role of niacin, riboflavin, and pyridoxine. This review aims to summarize the etiology, diagnosis, and treatment of nutritional optic neuropathy, and it is addressed not only to ophthalmologists, but to all physicians who could come in contact with a patient with a possible nutritional optic neuropathy, being a fundamental multidisciplinary approach.

scholarly journals Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies

2021 ◽  
Vol 22 (5) ◽  
pp. 2700
Author(s):  
Maria Teresa Valenti ◽  
Luca Dalle Carbonare ◽  
Donato Zipeto ◽  
Monica Mottes
Keyword(s):  
At Risk ◽  
Stem Cells ◽  
Therapeutic Targets ◽  
Therapeutic Strategies ◽  
Epigenetic Modifications ◽  
Degenerative Diseases ◽  
Metabolic Processes ◽  
Autophagy Pathway ◽  
Autophagic Process

Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications.

scholarly journals The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2060
Author(s):  
Federica Ungaro ◽  
Silvia D’Alessio ◽  
Silvio Danese
Keyword(s):  
Colorectal Cancer ◽  
State Of The Art ◽  
Therapeutic Strategies ◽  
Lipid Mediators ◽  
Adverse Side Effects ◽  
Endogenous Lipid ◽  
Protein Receptors ◽  
Inflammatory Drugs ◽  
Inflammatory Milieu

Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted researchers to propose the polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) as promoters of resolution of cancer-associated inflammation. SPMs were found to inhibit the CRC-associated pro-inflammatory milieu via specific G-coupled protein receptors, although clinical data are still lacking. This review aims to summarize the state-of-the-art in this field, ultimately providing insights for the development of innovative anti-CRC therapies that promote the endogenous lipid-mediated resolution of CRC-associated inflammation.

scholarly journals Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1584 ◽  
Author(s):  
Cedric Magaway ◽  
Eugene Kim ◽  
Estela Jacinto
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Clinical Studies ◽  
Cancer Metabolism ◽  
Therapeutic Strategies ◽  
Metabolic Reprogramming ◽  
Metabolic Processes ◽  
Mtor Inhibition ◽  
Early Clinical Trial

Cancer cells support their growth and proliferation by reprogramming their metabolism in order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to tumorigenesis, a common alteration in tumors occurs in pathways that upregulate nutrient acquisition. A central signaling pathway that controls metabolic processes is the mTOR pathway. The elucidation of the regulation and functions of mTOR can be traced to the discovery of the natural compound, rapamycin. Studies using rapamycin have unraveled the role of mTOR in the control of cell growth and metabolism. By sensing the intracellular nutrient status, mTOR orchestrates metabolic reprogramming by controlling nutrient uptake and flux through various metabolic pathways. The central role of mTOR in metabolic rewiring makes it a promising target for cancer therapy. Numerous clinical trials are ongoing to evaluate the efficacy of mTOR inhibition for cancer treatment. Rapamycin analogs have been approved to treat specific types of cancer. Since rapamycin does not fully inhibit mTOR activity, new compounds have been engineered to inhibit the catalytic activity of mTOR to more potently block its functions. Despite highly promising pre-clinical studies, early clinical trial results of these second generation mTOR inhibitors revealed increased toxicity and modest antitumor activity. The plasticity of metabolic processes and seemingly enormous capacity of malignant cells to salvage nutrients through various mechanisms make cancer therapy extremely challenging. Therefore, identifying metabolic vulnerabilities in different types of tumors would present opportunities for rational therapeutic strategies. Understanding how the different sources of nutrients are metabolized not just by the growing tumor but also by other cells from the microenvironment, in particular, immune cells, will also facilitate the design of more sophisticated and effective therapeutic regimen. In this review, we discuss the functions of mTOR in cancer metabolism that have been illuminated from pre-clinical studies. We then review key findings from clinical trials that target mTOR and the lessons we have learned from both pre-clinical and clinical studies that could provide insights on innovative therapeutic strategies, including immunotherapy to target mTOR signaling and the metabolic network in cancer.

A Comprehensive Review on Diagnostic and Therapeutic Strategies for the Management of Pancreatic Cancer

2020 ◽  
Author(s):  
Vibha Sinha ◽  
Sapnita Shinde ◽  
Saurabh Ssaxena ◽  
Suresh Thakur ◽  
Tamanna Walia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Strategies ◽  
Comprehensive Review

1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1758-P
Author(s):  
HUGO MARTIN ◽  
SÉBASTIEN BULLICH ◽  
FABIEN DUCROCQ ◽  
MARION GRALAND ◽  
CLARA OLIVRY ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mood Disorders ◽  
Serotonergic Neurons ◽  
P Type

Vitamin D in trichology: a comprehensive review of the role of vitamin D and its receptor in hair and scalp disorders

2020 ◽  
Vol 155 (2) ◽  
Author(s):  
Giovanni Damiani ◽  
Rosalynn Conic ◽  
Gloria Orlando ◽  
Anna Zampetti ◽  
Elena Marinello ◽  
...  
Keyword(s):  
Vitamin D ◽  
Comprehensive Review

Photosynthetic activity as the basis of potato productivity when using phytohormones

2020 ◽  
Author(s):  
A.V. Shitikova ◽  
◽  
A.A. Abiala
Keyword(s):  
Photosynthetic Activity ◽  
Moscow Region ◽  
Metabolic Processes ◽  
Biochemical Reactions ◽  
Podzolic Soils ◽  
Increase In Productivity

The results of studies on the role of growth biostimulants in the exogenous regulation of potato productivity on sod-podzolic soils of the Moscow region are presented.Studies have established the specificity of the action of phytohormones.The stimulating effect of the drugs manifested itself in the intensification of metabolic processes, changing the direction of biochemical reactions, which led to an increase in productivity.

EMDR as therapy for conditions other than PTSD: a systematic review.

2020 ◽  
Author(s):  
Charles Scelles ◽  
LUIS CARLO BULNES
Keyword(s):  
Mood Disorders ◽  
Obsessive Compulsive ◽  
Treatment As Usual ◽  
Compulsive Disorder ◽  
Adult Personality ◽  
Post Traumatic ◽  
Psychiatric Conditions ◽  
Research Criteria ◽  
Positive Effect

Eye Movement Desensitization and Reprocessing (EMDR) is a treatment for post-traumatic stressdisorder (PTSD). The technique is known to stimulate the capacity to reprocess maladaptive memoriesthat are thought to be central to this pathology. Here we investigate if EMDR therapy can be used in otherconditions than PTSD. We conducted a systematic literature search on PubMed, ScienceDirect, Scopus, and Web of Science. Wesearched for published empirical findings on EMDR, excluding those centred on trauma and PTSD,published up to 2020. The results were classified by psychiatric categories.   Ninety articles met our research criteria. A positive effect was reported in addictions, somatoformdisorders, sexual dysfunction, eating disorder, disorders of adult personality, mood disorders, reaction tosevere stress, anxiety disorders, performance anxiety, Obsessive-Compulsive Disorder (OCD), pain,neurodegenerative disorders, paedopsychiatry and sleep. The evidence was more consistent in pain, OCD,mood disorders, and reaction to severe stress.EMDR’s efficiency across numerous pathological situations, highlighted the central role of affectivememory in several psychiatric and non-psychiatric conditions. Furthermore, EMDR seems to besuccessful in usually uncooperative (e.g. Dementia) or unproductive cases (e.g. aphasia). Moreover, insome severe medical situations were psychologic distress was an obstacle, EMDR allowed thecontinuation of treatment-as-usual. Our review suggests that it is a safe and economical therapeuticoption, and its effect in non-pathological situations opens new avenues for translational research. Overallmore methodologically rigorous studies are needed.

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