The Critical Role of the miR-21-MEG2 Axis in Colorectal Cancer

2020 ◽  
Vol 30 (6) ◽  
pp. 509-518
Author(s):  
Zengtao Bao ◽  
Shanting Gao ◽  
Baoming Zhang ◽  
Wenchao Shi ◽  
Aimin Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role

Abstract 1558: The critical role of lymph node stromal cell-derived microvesicles in colorectal cancer metastasis

2016 ◽  
Author(s):  
Xin Zhang ◽  
Ryan Sullivan ◽  
Nathan Hite ◽  
Grace Maresh ◽  
Linh Hellmers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Stromal Cell ◽  
Cancer Metastasis ◽  
Critical Role ◽  
Colorectal Cancer Metastasis

The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer

2019 ◽  
Vol 104 (5) ◽  
pp. 1153-1164 ◽  
Author(s):  
Na Liu ◽  
Weiyingqi Cui ◽  
Xia Jiang ◽  
Zhiyong Zhang ◽  
Sebastian Gnosa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Critical Role

scholarly journals Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis

2017 ◽  
Vol 14 (11) ◽  
pp. 1154-1162 ◽  
Author(s):  
Hui-Ying Lu ◽  
Ri-Tian Lin ◽  
Guang-Xi Zhou ◽  
Tian-Ming Yu ◽  
Zhan-Ju Liu
Keyword(s):  
Colorectal Cancer ◽  
Critical Role ◽  
Early Colorectal Cancer ◽  
Single Center ◽  
One Year

OC.14.2: Critical Role of the IL-33/ST2 Axis in Colitis-Associated Colorectal Cancer

2017 ◽  
Vol 49 ◽  
pp. e117
Author(s):  
L.R. Lopetuso ◽  
C. De Salvo ◽  
L. Di Martino ◽  
W. Goodman ◽  
F. Scaldaferri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role

scholarly journals Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Lei Lei ◽  
Jianan Zhang ◽  
Eric A. Decker ◽  
Guodong Zhang
Keyword(s):  
Colorectal Cancer ◽  
Lipid Peroxidation ◽  
Critical Role ◽  
Redox Stress ◽  
Colonic Inflammation ◽  
Colon Tumorigenesis ◽  
Inflammatory Bowel

Redox stress is a common feature of gut disorders such as colonic inflammation (inflammatory bowel disease or IBD) and colorectal cancer (CRC). This leads to increased colonic formation of lipid-derived electrophiles (LDEs) such as 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), trans, trans-2,4-decadienal (tt-DDE), and epoxyketooctadecenoic acid (EKODE). Recent research by us and others support that treatment with LDEs increases the severity of colitis and exacerbates the development of colon tumorigenesis in vitro and in vivo, supporting a critical role of these compounds in the pathogenesis of IBD and CRC. In this review, we will discuss the effects and mechanisms of LDEs on development of IBD and CRC and lifestyle factors, which could potentially affect tissue levels of LDEs to regulate IBD and CRC development.

Su1861 Critical Role of the IL-33/ST2 Axis in Colitis-Associated Colorectal Cancer

2016 ◽  
Vol 150 (4) ◽  
pp. S573
Author(s):  
Loris R. Lopetuso ◽  
Carlo De Salvo ◽  
Luca Di Martino ◽  
Wendy Goodman ◽  
Franco Scaldaferri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role

scholarly journals N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer Proliferation via YAP1

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Zheng ◽  
Yue Wang ◽  
Yiyang Liu ◽  
Longfei Xie ◽  
Jinnian Ge ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Expression Profiles ◽  
Critical Role ◽  
Methylation Status ◽  
Tumor Model ◽  
Loss Of Function ◽  
Cancer Proliferation ◽  
Mrna Binding

BackgroundLong noncoding RNAs (lncRNAs) have emerged to have irreplaceable roles in the epigenetic regulation of cancer progression, but their biological functions in colorectal cancer (CRC) remain unclear.MethodsLncRNA expression profiles in CRC tissue and their normal counterpart were explored. Through gain and loss of function approaches, the role of lncRNA PTTG3P was validated in relevant CRC cells and subcutaneous tumor model. The correlations of PTTG3P expression with clinical outcomes were assessed.ResultsPTTG3P was upregulated in CRC tissues and was closely correlated with unsatisfactory prognosis. PTTG3P facilitated glycolysis and proliferation, and the transcriptional regulator YAP1 was necessary for PTTG3P-induced proliferation. Mechanistically, the N6-methyladenosine (m6A) subunit METTL3 increased PTTG3P expression by influencing its stability, while insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) could identify PTTG3P m6A methylation status and bind to it. IGF2BP2 knockdown partly recovered PTTG3P expression induced by METTL3, indicating that METTL3-regulated PTTG3P expression depended on the presence of IGF2BP2. Finally, rescue assays validated the critical role of the METTL3/PTTG3P/YAP1 axis on CRC proliferation.ConclusionsPTTG3P is an independent prognostic biomarker for CRC. The METTL3/PTTG3P/YAP1 axis promotes the progression of CRC and is a promising treatment target.

scholarly journals Erratum: Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

2013 ◽  
Vol 4 (8) ◽  
pp. e748-e748 ◽  
Author(s):  
M D Bullock ◽  
K M Pickard ◽  
B S Nielsen ◽  
A E Sayan ◽  
V Jenei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Critical Role ◽  
Colorectal Cancer Progression ◽  
Pleiotropic Actions
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