scholarly journals Multidisciplinary Management of Retroperitoneal Sarcoma: Diagnosis, Prognostic Factors and Treatment

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4016
Author(s):  
Fabio Carbone ◽  
Antonio Pizzolorusso ◽  
Giuseppe Di Lorenzo ◽  
Massimiliano Di Marzo ◽  
Lucia Cannella ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Therapeutic Strategy ◽  
Therapeutic Option ◽  
High Volume ◽  
Distant Recurrence ◽  
Multiple Organ ◽  
Multidisciplinary Management ◽  
Comprehensive Overview ◽  
Factors Analysis ◽  
Retroperitoneal Sarcomas

Retroperitoneal sarcomas (RPS) are rare cancers whose management can be challenging due to various presentation patterns, multiple organ involvement, and a high local and distant recurrence rate. Histopathology and prognostic factors analysis are essential to predict the behaviour of the disease and plan the best therapeutic strategy. To date, surgery is still the main therapeutic option that guarantees a chance of cure from the primary disease. While chemotherapy and radiotherapy seem to be good options for controlling metastatic and recurrent irresectable disease, their role in the treatment of primary RPS remains unclear. This literature review aims to provide a comprehensive overview of the multidisciplinary aspects of RPS management in high-volume centres, summarising the diagnostic path, the prognostic factors, and the most suitable therapeutic options.

Glioblastoma: Prognostic Factors and Predictive Response to Radio and Chemotherapy

2020 ◽  
Vol 27 (17) ◽  
pp. 2814-2825
Author(s):  
Francesco Fiorica ◽  
Maria Colella ◽  
Rosaria Taibi ◽  
Andrea Bonetti ◽  
Jacopo Giuliani ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Glioblastoma Multiforme ◽  
Poor Prognosis ◽  
Therapeutic Strategy ◽  
Biological Factors ◽  
Near Future ◽  
Predictive Response

: Glioblastoma multiforme (GBM) is characterized by poor prognosis despite an aggressive therapeutic strategy. In recent years, many advances have been achieved in the field of glioblastoma biology. : Here we try to summarize the main clinical and biological factors impacting clinical prognostication and therapy of GBM patients. From that standpoint, hopefully, in the near future, personalized therapies will be available.

scholarly journals Radiation Therapy without Surgery for Spinal Metastases: Clinical Outcome and Prognostic Factors Analysis for Pain Control

2012 ◽  
Vol 2 (3) ◽  
pp. 137-141
Author(s):  
Akira Matsumura ◽  
Manabu Hoshi ◽  
Masatsugu Takami ◽  
Takahiko Tashiro ◽  
Hiroaki Nakamura
Keyword(s):  
Radiation Therapy ◽  
Prognostic Factors ◽  
Clinical Outcome ◽  
Pain Control ◽  
Spinal Metastases ◽  
Factors Analysis

Prognostic Factors in Retroperitoneal Sarcomas

2021 ◽  
Vol 47 (2) ◽  
pp. e59-e60
Author(s):  
João Carvas ◽  
Pedro Martins ◽  
Mariana Peyroteo ◽  
Rita Canotilho ◽  
Ana Margarida Correia ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Retroperitoneal Sarcomas

Management of Recurrent Retroperitoneal Sarcoma

2017 ◽  
Author(s):  
Armen Parsyan ◽  
Abha Gupta ◽  
Charles Catton ◽  
Rebecca Gladdy
Keyword(s):  
Local Recurrence ◽  
Surgical Resection ◽  
Multivisceral Resection ◽  
Distant Recurrence ◽  
Retroperitoneal Sarcoma ◽  
Key Words Chemotherapy ◽  
Pattern Of Failure ◽  
Mesenchymal Tumors ◽  
Retroperitoneal Sarcomas ◽  
High Level

Retroperitoneal sarcomas (RPSs) are a heterogeneous group of mesenchymal tumors. The mainstay of treatment of RPS is curative surgical resection, which often involves a multivisceral resection. The predominant pattern of failure in RPS is local recurrence, which poses significant management challenges and limits survival. There is a paucity of high-level evidence to guide the management of primary and recurrent RPS, mainly due to the rarity of the disease. This review highlights the challenges and decision making in the diagnosis and management of recurrent RPS.  This review contains 6 figures, 5 tables and 50 references Key words: chemotherapy, distant recurrence, leiomyosarcoma, liposarcoma, local recurrence, radiation therapy, retroperitoneal sarcoma, surgical resection 

scholarly journals Multicentric French study on adult intracranial ependymomas: prognostic factors analysis and therapeutic considerations from a cohort of 152 patients

Brain ◽  
2007 ◽  
Vol 130 (5) ◽  
pp. 1338-1349 ◽  
Author(s):  
P. Metellus ◽  
M. Barrie ◽  
D. Figarella-Branger ◽  
O. Chinot ◽  
R. Giorgi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Factors Analysis ◽  
French Study ◽  
Therapeutic Considerations

scholarly journals Hydrogen Sulfide: A Therapeutic Option in Systemic Sclerosis

2018 ◽  
Vol 19 (12) ◽  
pp. 4121 ◽  
Author(s):  
Amaal Abdulle ◽  
Harry van Goor ◽  
Douwe Mulder
Keyword(s):  
Hydrogen Sulfide ◽  
Systemic Sclerosis ◽  
Animal Studies ◽  
Therapeutic Option ◽  
Multiple Organ ◽  
Current Data ◽  
Organ Systems ◽  
Transsulfuration Pathway ◽  
Exact Etiology ◽  
Vascular Physiology

Systemic sclerosis (SSc) is a lethal disease that is characterized by auto-immunity, vascular injury, and progressive fibrosis of multiple organ systems. Despite the fact that the exact etiology of SSc remains unknown, oxidative stress has been associated with a large range of SSc-related complications. In addition to the well-known detrimental properties of reactive oxygen species (ROS), gasotransmitters (e.g., nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)) are also thought to play an important role in SSc. Accordingly, the diverse physiologic actions of NO and CO and their role in SSc have been previously studied. Recently, multiple studies have also shown the importance of the third gasotransmitter H2S in both vascular physiology and pathophysiology. Interestingly, homocysteine (which is converted into H2S through the transsulfuration pathway) is often found to be elevated in SSc patients; suggesting defects in the transsulfuration pathway. Hydrogen sulfide, which is known to have several effects, including a strong antioxidant and vasodilator effect, could potentially play a prominent role in the initiation and progression of vasculopathy. A better understanding of the actions of gasotransmitters, like H2S, in the development of SSc-related vasculopathy, could help to create early interventions to attenuate the disease course. This paper will review the role of H2S in vascular (patho-)physiology and potential disturbances in SSc. Moreover, current data from experimental animal studies will be reviewed. Lastly, we will evaluate potential interventional strategies.

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