Health-Related Quality of Life in Locally Advanced Gastric Cancer: A Systematic Review

Background: Current treatment strategies have been designed to improve survival in locally advanced gastric cancer patients. Besides its impact on survival, treatment also affects health-related quality of life (HRQOL), but an overview of reported studies is currently lacking. The aim of this systematic review was therefore to determine the short- and long-term impact of chemotherapy, surgery, and (chemo)radiotherapy on HRQOL in locally advanced, non-metastatic gastric cancer patients. Methods: A systematic review was performed including studies published between January 2000 and February 2021. We extracted studies published in Medline, Embase, and Scopus databases that assessed HRQOL in patients with locally advanced, non-metastatic gastric cancer treated with curative intent. Studies using non-validated HRQOL questionnaires were excluded. Short-term and long-term HRQOL were defined as HRQOL scores within and beyond 6 months after treatment, respectively. Results: Initially, we identified 8705 articles (4037 of which were duplicates, i.e., 46%) and ultimately included 10 articles. Most studies reported that short-term HRQOL worsened in the follow-up period from 6 weeks to 3 months after surgery. However, recovery of HRQOL to preoperative levels occurred after 6 months. After completion of chemoradiotherapy, the same pattern was seen with worse HRQOL after treatment and a recovery of HRQOL after 6–12 months. Conclusions: In patients with locally advanced, non-metastatic gastric cancer, HRQOL deteriorated during the first 3 months after surgery and chemoradiotherapy. However, the long-term data showed a recovery of HRQOL after 6–12 months. To implement HRQOL in clinical decision making in current clinical practice, more research is needed.

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Comparison of health-related quality of life with epirubicin, cisplatin plus 5-fluorouracil and docetaxel, cisplatin plus 5-fluorouracil chemotherapy regimens as first-line systemic therapy in locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma: A prospective study from South India

South Asian Journal of Cancer ◽

10.4103/sajc.sajc_8_17 ◽

2018 ◽

Vol 07 (01) ◽

pp. 11-15

Author(s):

K. Govind Babu ◽

Tamojit Chaudhuri ◽

K. C. Lakshmaiah ◽

Lokanatha Dasappa ◽

Linu Abraham Jacob ◽

...

Keyword(s):

Quality Of Life ◽

Gastric Cancer ◽

Prospective Study ◽

Locally Advanced ◽

Metastatic Gastric Cancer ◽

Health Related Quality ◽

First Line ◽

Related Quality ◽

Health Related

Abstract Background: Health-related quality of life (HRQOL) is an important oncologic end point for upper gastrointestinal malignancies. Unfortunately, till date, there is no published prospective data from India, comparing the HRQOL parameters between first-line chemotherapy regimens in advanced/metastatic gastric cancer. Materials and Methods: The present study aimed to compare the HRQOL of first-line systemic chemotherapy with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens in patients with locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma. The secondary end points were overall response rate, progression-free survival (PFS), overall survival (OS), and toxicity profile. Results: Between December 2014 and December 2016, 65 patients were treated with ECF (n= 34) or DCF (n= 31) regimen. The baseline HRQOL scores were comparable between the two study groups, with the exception of significantly poor pain and sleep difficulties symptom score in the DCF group. After three cycles of treatment, both the groups showed improvements in most of the quality of life (QOL) parameters including global QOL score, compared with their baseline status. After six cycles of chemotherapy, the ECF group showed nonsignificant deterioration for most of the QOL parameters; but on the contrary, the DCF group maintained improved scores for most of the QOL parameters. The median survival until a definitive deterioration of global QOL score was significantly better in the DCF arm in comparison to the ECF arm (7.1 vs. 5.6 months, respectively, P = 0.000). The median OS was 9.2 months with ECF and 12.5 months with DCF regimen (P = 0.000), while median PFS was 5.7 and 7.4 months with ECF and DCF regimens, respectively (P = 0.002). Conclusions: This prospective study highlighted a better impact of DCF chemotherapy on the HRQOL of patients with advanced/metastatic gastric cancer and showed the importance of QOL assessments in clinical trials to complement the risk–benefit judgment.

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Definitive radiotherapy with adjuvant long-term antiandrogen treatment for locally advanced prostate cancer: health-related quality of life and hormonal changes

Prostate Cancer and Prostatic Diseases ◽

10.1038/pcan.2009.8 ◽

2009 ◽

Vol 12 (3) ◽

pp. 269-276 ◽

Cited By ~ 7

Author(s):

A Berg ◽

A A Dahl ◽

Ø S Bruland ◽

T Bjøro ◽

M S Aanensen ◽

...

Keyword(s):

Quality Of Life ◽

Advanced Prostate Cancer ◽

Locally Advanced ◽

Hormonal Changes ◽

Health Related Quality ◽

Locally Advanced Prostate Cancer ◽

Related Quality ◽

Health Related

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Health-related quality of life in patients receiving long-term opioid therapy: a systematic review with meta-analysis

Quality of Life Research ◽

10.1007/s11136-017-1538-0 ◽

2017 ◽

Vol 26 (8) ◽

pp. 1955-1967 ◽

Cited By ~ 6

Author(s):

J. Douglas Thornton ◽

Rashmi Goyat ◽

Nilanjana Dwibedi ◽

George A. Kelley

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Meta Analysis ◽

Opioid Therapy ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Quality of Life in Vietnamese Gastric Cancer Patients

BioMed Research International ◽

10.1155/2019/7167065 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Dzung Ngoc Thi Dang ◽

Lan Ngoc Thi Nguyen ◽

Nga Thi Dang ◽

Huy Quang Dang ◽

Thanh Van Ta

Keyword(s):

Quality Of Life ◽

Gastric Cancer ◽

Cancer Patients ◽

Disease Stage ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Gastric Cancer Patients ◽

Personal Functioning

Background. Gastric cancer (GC) is one of the leading causes of cancer-related death in Vietnam. Research on health-related quality of life of Vietnamese gastric cancer patients is still in its infancy. Aim. To assess the health-related quality of life (HRQOL) of GC patients using the 15D instrument. Materials and Method. 182 Vietnamese gastric cancer patients were selected to be interviewed and their HRQOL was assessed using the generic 15D questionnaire. Tables regarding history, disease characteristics, and HRQOL of participants were formulated according to genders using STATA 12.0. Results. The average age of the participants was 60.8 ± 11.6. The average time from diagnosis to the date of interview was 14.8 ± 8.4 months. The health-related quality of life (HRQOL) index score of gastric cancer patients using the 15D instrument was 0.92 ± 0.08, in which the “sexual activity” dimension had the lowest score of 0.66. Also, our study found several factors affecting HRQOL, including age, occupation, education, disease stage, treatment, and time from the date of diagnosis. Conclusion. The 15D instrument was a suitable tool to assess Vietnamese gastric cancer patients’ quality of life. Findings from the study suggest the importance of frequently measuring personal functioning and performance of GC patients as parts of QOL assessment during clinical examination. It also implies the needs for more focused policies on raising the overall quality of life of patients such as encouragement of periodical HQROL assessment and acknowledging HRQOL as a treatment/intervention goal besides the 5-year survival rate.

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