scholarly journals Flow Pd(II)-Catalysced Carbonylative Cyclisation in the Total Synthesis of Jaspine B

Catalysts ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1513
Author(s):  
Pavol Lopatka ◽  
Michal Gavenda ◽  
Martin Markovič ◽  
Peter Koóš ◽  
Tibor Gracza
Keyword(s):  
Carbon Monoxide ◽  
Total Synthesis ◽  
Large Scale ◽  
Flow Reactor ◽  
Stoichiometric Amount ◽  
Large Scale Preparation ◽  
Molar Equivalent ◽  
Scale Preparation ◽  
Jaspine B

This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved the pBQ/LiCl as a reoxidation system and Fe(CO)5 as an in situ source of stoichiometric amount of carbon monoxide (1.5 molar equivalent). In addition, we have demonstrated the use of a flow reactor adopting proposed conditions in the large-scale preparation of key lactones.

Highly-Efficient Preparation of Key Intermediate of Huperzine A

2014 ◽  
Vol 484-485 ◽  
pp. 157-160
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

Highly-Efficient Preparation of Key Intermediate of Huperzine A

2013 ◽  
Vol 803 ◽  
pp. 181-184
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

An Innovative Microwave Process for Nanocatalyst Synthesis

2010 ◽  
Vol 8 (1) ◽  
Author(s):  
Claudia Antonetti ◽  
Anna Maria Raspolli Galletti ◽  
Iginio Longo
Keyword(s):  
Selective Hydrogenation ◽  
Large Scale ◽  
Synthesis Methods ◽  
Microwave Chemistry ◽  
Large Scale Preparation ◽  
Palladium Nanocatalysts ◽  
Scale Preparation ◽  
Novel Method ◽  
And Control

The development of greener chemical processes is becoming more and more important because this approach moves towards sustainable methods and products, minimizing pollution and risks for human health and environment. In these perspectives, microwaves seem to fulfil these requirements; in this context, we have tested a novel method both for the synthesis of nanocatalysts and for thermal activation of catalytic reactions. Until now, microwave chemistry has been generally performed inside a closed metal cavity, i.e. a microwave oven, but this approach presents relevant drawbacks, in particular for large scale application. Recently, we have proposed a new, cheap, sustainable process for large scale preparation of nanocatalysts, overcoming the disadvantages of the current synthesis methods. This novel method has been successfully adopted for the preparation in situ of ruthenium, palladium and silver nanoparticles as colloids or on different supports. Our procedure is safe and cheap, enabling to obtain the utmost efficiency and control also for industrial application. The obtained nanocatalysts present small average diameters, good morphology and very narrow sizes distribution with an absolute reproducibility. The ruthenium nanocatalysts were tested in the selective hydrogenation of phenol to cyclohexanone and palladium nanocatalysts were tested in the selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde, and we obtained good performances in both reactions.

Purification of the Antihemophilic Factor by Gel Filtration on Agarose

1969 ◽  
Vol 22 (03) ◽  
pp. 577-583 ◽  
Author(s):  
M.M.P Paulssen ◽  
A.C.M.G.B Wouterlood ◽  
H.L.M.A Scheffers
Keyword(s):  
Factor Viii ◽  
Plasma Proteins ◽  
Large Scale ◽  
Gel Filtration ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Antihemophilic Factor

SummaryFactor VIII can be isolated from plasma proteins, including fibrinogen by chromatography on agarose. The best results were obtained with Sepharose 6B. Large scale preparation is also possible when cryoprecipitate is separated by chromatography. In most fractions containing factor VIII a turbidity is observed which may be due to the presence of chylomicrons.The purified factor VIII was active in vivo as well as in vitro.

The occurrence of long chain polyprenols in leaves of plants of Rosaceae family and their isolation by time-extended liquid chromatography

1992 ◽  
Vol 70 (6) ◽  
pp. 448-454 ◽  
Author(s):  
Ewa Świeżewska ◽  
T. Chojnacki ◽  
W. J. Jankowski ◽  
K. Singh ◽  
J. Olsson
Keyword(s):  
Liquid Chromatography ◽  
Fatty Acid ◽  
Large Scale ◽  
Fatty Acid Esters ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Wet Weight ◽  
Rosaceae Family ◽  
Acid Esters ◽  
Long Chain

The long chain polyprenols composed of 30 and more isoprene units from leaves of plants belonging to the genera Potentilla and Rosa have been described. They occur in the form of fatty acid esters. The composition of polyprenol mixture was species dependent and its content reached ca. 0.5% wet weight. Large scale preparation of individual polyprenols from a natural polyprenol mixture was performed using time-extended liquid chromatography on the hydrophobic gel Lipidex-5000.Key words: long chain polyprenols, Rosaceae.

Sign in / Sign up

Export Citation Format

Share Document