Highly-Efficient Preparation of Key Intermediate of Huperzine A

2014 ◽  
Vol 484-485 ◽  
pp. 157-160
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

Highly-Efficient Preparation of Key Intermediate of Huperzine A

2013 ◽  
Vol 803 ◽  
pp. 181-184
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation

2000 ◽  
Vol 4 (6) ◽  
pp. 520-525 ◽  
Author(s):  
Tomomi Ikemoto ◽  
Tatsuya Ito ◽  
Hideo Hashimoto ◽  
Tadao Kawarasaki ◽  
Atsuko Nishiguchi ◽  
...  
Keyword(s):  
Large Scale ◽  
Ccr5 Antagonist ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Scale Preparation

scholarly journals Flow Pd(II)-Catalysced Carbonylative Cyclisation in the Total Synthesis of Jaspine B

Catalysts ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1513
Author(s):  
Pavol Lopatka ◽  
Michal Gavenda ◽  
Martin Markovič ◽  
Peter Koóš ◽  
Tibor Gracza
Keyword(s):  
Carbon Monoxide ◽  
Total Synthesis ◽  
Large Scale ◽  
Flow Reactor ◽  
Stoichiometric Amount ◽  
Large Scale Preparation ◽  
Molar Equivalent ◽  
Scale Preparation ◽  
Jaspine B

This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved the pBQ/LiCl as a reoxidation system and Fe(CO)5 as an in situ source of stoichiometric amount of carbon monoxide (1.5 molar equivalent). In addition, we have demonstrated the use of a flow reactor adopting proposed conditions in the large-scale preparation of key lactones.

scholarly journals Highly efficient large-scale preparation and electromagnetic property control of silica–NiFeP double shell composite hollow particles

RSC Advances ◽  
2017 ◽  
Vol 7 (35) ◽  
pp. 21721-21732 ◽  
Author(s):  
Bin Liao ◽  
Zhenguo An ◽  
Jingjie Zhang
Keyword(s):  
Large Scale ◽  
Electromagnetic Property ◽  
Hollow Particles ◽  
Scale Method ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Electromagnetic Behavior ◽  
Property Control ◽  
Shell Composite

Micron-sized double shell composite hollow particles with excellent electromagnetic behavior are prepared using a highly efficient and large scale method.

ChemInform Abstract: Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation.

ChemInform ◽  
2001 ◽  
Vol 32 (15) ◽  
pp. no-no
Author(s):  
Tomomi Ikemoto ◽  
Tatsuya Ito ◽  
Hideo Hashimoto ◽  
Tadao Kawarasaki ◽  
Atsuko Nishiguchi ◽  
...  
Keyword(s):  
Large Scale ◽  
Ccr5 Antagonist ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Scale Preparation

Synthesis of Soluble Carcerands

2012 ◽  
Vol 1371 ◽  
Author(s):  
Jiménez-Gutiérrez I. Eddy ◽  
Sánchez-Montes K. Erika ◽  
Cortez-Maya Sandra ◽  
Flores-Rojas Gabriel ◽  
Martínez-García Marcos
Keyword(s):  
Elemental Analysis ◽  
Good Yield ◽  
Large Scale ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Vis Spectroscopy ◽  
Scale Preparation ◽  
C Nmr ◽  
Oxygen Atoms

ABSTRACTAn efficient synthetic route for the synthesis of carcerands derived from tetramethylchlorocavitands and its tetraesters derivative were synthesized. A large-scale preparation was achieved in good yield. These carcerands are in bridging unit between oxygen atoms, i.e. contains a 3,5 dihydroxybencyl alcohol units. 1H, and 13C NMR in solution, FTIR, UV-vis spectroscopy, MS-FAB+ spectrometry and elemental analysis confirmed the structure of this carcerands.

Purification of the Antihemophilic Factor by Gel Filtration on Agarose

1969 ◽  
Vol 22 (03) ◽  
pp. 577-583 ◽  
Author(s):  
M.M.P Paulssen ◽  
A.C.M.G.B Wouterlood ◽  
H.L.M.A Scheffers
Keyword(s):  
Factor Viii ◽  
Plasma Proteins ◽  
Large Scale ◽  
Gel Filtration ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Antihemophilic Factor

SummaryFactor VIII can be isolated from plasma proteins, including fibrinogen by chromatography on agarose. The best results were obtained with Sepharose 6B. Large scale preparation is also possible when cryoprecipitate is separated by chromatography. In most fractions containing factor VIII a turbidity is observed which may be due to the presence of chylomicrons.The purified factor VIII was active in vivo as well as in vitro.

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