scholarly journals Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1102 ◽  
Author(s):  
Sonali Nashine ◽  
M. Cristina Kenney
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Mechanisms Of Action ◽  
Age Related Macular Degeneration ◽  
Age Related

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.

scholarly journals Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration

2021 ◽  
Vol 6 (1) ◽  
pp. e000774
Author(s):  
Minwei Wang ◽  
Shiqi Su ◽  
Shaoyun Jiang ◽  
Xinghuai Sun ◽  
Jiantao Wang
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Vision Loss ◽  
Cell Structure ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Amyloid Β ◽  
Age Related Macular Degeneration ◽  
Amyloid Β Peptide ◽  
Age Related

Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summarise the current findings in this field. The literature search was done from 1995 to Feb, 2021 with following keywords, ‘Amyloid β-peptide and age-related macular degeneration’, ‘Inflammation and age-related macular degeneration’, ‘Angiogenesis and age-related macular degeneration’, ‘Actin cytoskeleton and amyloid β-peptide’, ‘Mitochondrial dysfunction and amyloid β-peptide’, ‘Ribosomal dysregulation and amyloid β-peptide’ using search engines Pubmed, Google Scholar and Web of Science. Aβ congregates in subretinal drusen of patients with AMD and participates in the pathogenesis of AMD through enhancing inflammatory activity, inducing mitochondrial dysfunction, altering ribosomal function, regulating the lysosomal pathway, affecting RNA splicing, modulating angiogenesis and modifying cell structure in AMD. The methods targeting Aβ are shown to inhibit inflammatory signalling pathway and restore the function of retinal pigment epithelium cells and photoreceptor cells in the subretinal region. Targeting Aβ may provide a novel therapeutic strategy for AMD.

scholarly journals Hyperspectral autofluorescence characterization of drusen and sub-RPE deposits in age-related macular degeneration

2021 ◽  
Vol 6 ◽  
pp. 4-4
Author(s):  
Yuehong Tong ◽  
Thomas Ach ◽  
Christine A. Curcio ◽  
R. Theodore Smith
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration

2012 ◽  
Vol 4 (17) ◽  
pp. 2153-2161 ◽  
Author(s):  
Kai Kaarniranta ◽  
Anu Kauppinen ◽  
Janusz Blasiak ◽  
Antero Salminen
Keyword(s):  
Macular Degeneration ◽  
Therapeutic Targets ◽  
Age Related Macular Degeneration ◽  
Age Related

Noninvasive Imaging of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration

2012 ◽  
Vol 43 (5) ◽  
pp. 358-365 ◽  
Author(s):  
Matthew G. Field ◽  
Grant M. Comer ◽  
Takahiro Kawaji ◽  
Howard R. Petty ◽  
Victor M. Elner
Keyword(s):  
Mitochondrial Dysfunction ◽  
Macular Degeneration ◽  
Noninvasive Imaging ◽  
Age Related Macular Degeneration ◽  
Age Related
Sign in / Sign up

Export Citation Format

Share Document