scholarly journals Laser Illumination Adjustments for Signal-to-Noise Ratio and Spatial Resolution Enhancement in Static 2D Chemical Images of NbOx/IGZO/ITO/Glass Light-Addressable Potentiometric Sensors

Chemosensors ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 313
Author(s):  
Chun-Hui Chen ◽  
Neelanjan Akuli ◽  
Yu-Jen Lu ◽  
Chia-Ming Yang
Keyword(s):  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Low Cost ◽  
Resolution Enhancement ◽  
Cell Activity ◽  
Potentiometric Sensors ◽  
Signal To Noise ◽  
Critical Dimensions ◽  
Ito Glass ◽  
Noise Ratio

In a previous study, a thin In-Ga-Zn-oxide light addressable potentiometric sensor (IGZO LAPS) was indicated to have the advantages of low interference from ambient light, a high photocurrent and transfer efficiency, and a low cost. However, illumination optimization to obtain two-dimensional (2D) chemical images with better spatial resolutions has not been fully investigated. The trigger current and AC-modulated frequency of a 405-nm laser used to illuminate the fabricated IGZO LAPS were modified to check the photocurrent of the sensing area and SU8–2005 masking area, obtaining spatial resolution-related functions for the first time. The trigger current of illumination was adjusted from 0.020 to 0.030 A to compromise between an acceptable photocurrent and the integrity of the SU8–2005 masking layer. The photocurrent (PC) and differential photocurrent (DPC) versus scanning length (SL) controlled by an X-Y stage were used to check the resolved critical dimensions (CDs). The difference between resolved CD and optically measured CD (e.g., delta CD) measured at an AC frequency of 500 Hz revealed overall smaller values, supporting precise measurement in 2D imaging. The signal-to-noise ratio (SNR) has an optimized range of 2.0 to 2.15 for a better resolution for step spacings of both 10 and 2 μm in the scanning procedure to construct static 2D images. Under illumination conditions with a trigger current of 0.025 A and at an AC frequency of 500 Hz, the spatial resolution can be reduced to 10 μm from the pattern width of 6 μm. This developed methodology provides a quantitative evaluation with further optimization in spatial resolution without an extra cost for applications requiring a high spatial resolution, such as single-cell activity.

Internally Modulated Chirped Pulse Based Direct Detection Type φ-OTDR System with High Signal-to-Noise Ratio and Low Cost

2019 ◽  
Vol 46 (8) ◽  
pp. 0806003
Author(s):  
李鲁川 Luchuan Li ◽  
卢斌 Bin Lu ◽  
王校 Xiao Wang ◽  
梁嘉靖 Jiajing Liang ◽  
郑汉荣 Hanrong Zheng ◽  
...  
Keyword(s):  
Direct Detection ◽  
Signal To Noise Ratio ◽  
Low Cost ◽  
High Signal ◽  
Signal To Noise ◽  
Chirped Pulse ◽  
Noise Ratio

Spatial resolution and signal-to-noise ratio in x-ray imaging

2019 ◽  
Author(s):  
Timur Gureyev ◽  
David M. Paganin ◽  
Alex Kozlov ◽  
Harry Quiney
Keyword(s):  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Signal To Noise ◽  
X Ray ◽  
X Ray Imaging ◽  
Noise Ratio

k-Space filtering in 2D gradient-echo breath-hold hyperpolarized3He MRI: Spatial resolution and signal-to-noise ratio considerations

2002 ◽  
Vol 47 (4) ◽  
pp. 687-695 ◽  
Author(s):  
Jim M. Wild ◽  
Martyn N.J. Paley ◽  
Magalie Viallon ◽  
Wolfgang G. Schreiber ◽  
Edwin J.R. van Beek ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Breath Hold ◽  
Gradient Echo ◽  
Signal To Noise ◽  
Noise Ratio

scholarly journals Comparing current noise in biological and solid-state nanopores

2019 ◽  
Author(s):  
A. Fragasso ◽  
S. Schmid ◽  
C. Dekker
Keyword(s):  
Solid State ◽  
Single Molecule ◽  
Signal To Noise Ratio ◽  
Low Cost ◽  
Ionic Current ◽  
Low Noise ◽  
Signal To Noise ◽  
Experimental Conditions ◽  
High Frequencies ◽  
Noise Ratio

AbstractNanopores bear great potential as single-molecule tools for bioanalytical sensing and sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost. The detection principle relies on detecting small differences in the ionic current as biomolecules traverse the nanopore. A major bottleneck for the further progress of this technology is the noise that is present in the ionic current recordings, because it limits the signal-to-noise ratio and thereby the effective time resolution of the experiment. Here, we review the main types of noise at low and high frequencies and discuss the underlying physics. Moreover, we compare biological and solid-state nanopores in terms of the signal-to-noise ratio (SNR), the important figure of merit, by measuring free translocations of a short ssDNA through a selected set of nanopores under typical experimental conditions. We find that SiNx solid-state nanopores provide the highest SNR, due to the large currents at which they can be operated and the relatively low noise at high frequencies. However, the real game-changer for many applications is a controlled slowdown of the translocation speed, which for MspA was shown to increase the SNR >160-fold. Finally, we discuss practical approaches for lowering the noise for optimal experimental performance and further development of the nanopore technology.

scholarly journals Novel Configurations of Ultrahigh Frequency (≤600 MHz) Analog Frontend for High Resolution Ultrasound Measurement

Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2598
Author(s):  
Min Kim ◽  
Jinhyoung Park ◽  
Qifa Zhou ◽  
Koping Shung
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Ultrahigh Frequency ◽  
Ultrasound Measurement ◽  
Functional Responses ◽  
Signal To Noise ◽  
Coded Excitation ◽  
Noise Ratio ◽  
The Difference

In this article, an approach to designing and developing an ultrahigh frequency (≤600 MHz) ultrasound analog frontend with Golay coded excitation sequence for high resolution imaging applications is presented. For the purpose of visualizing specific structures or measuring functional responses of micron-sized biological samples, a higher frequency ultrasound is needed to obtain a decent spatial resolution while it lowers the signal-to-noise ratio, the difference in decibels between the signal level and the background noise level, due to the higher attenuation coefficient. In order to enhance the signal-to-noise ratio, conventional approach was to increase the transmit voltage level. However, it may cause damaging the extremely thin piezoelectric material in the ultrahigh frequency range. In this paper, we present a novel design of ultrahigh frequency (≤600 MHz) frontend system capable of performing pseudo Golay coded excitation by configuring four independently operating pulse generators in parallel and the consecutive delayed transmission from each channel. Compared with the conventional monocycle pulse approach, the signal-to-noise ratio of the proposed approach was improved by 7–9 dB without compromising the spatial resolution. The measured axial and lateral resolutions of wire targets were 16.4 µm and 10.6 µm by using 156 MHz 4 bit pseudo Golay coded excitation, respectively and 4.5 µm and 7.7 µm by using 312 MHz 4 bit pseudo Golay coded excitation, respectively.

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