scholarly journals Familial and Genetic Influences on the Common Pediatric Primary Pain Disorders: A Twin Family Study

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 89
Author(s):  
David Champion ◽  
Minh Bui ◽  
Aneeka Bott ◽  
Theresa Donnelly ◽  
Shuxiang Goh ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Family Members ◽  
Recurrent Abdominal Pain ◽  
Persistent Pain ◽  
Genetic Influences ◽  
Low Back ◽  
Association Analyses ◽  
Growing Pains

The primary pain disorders of childhood are highly prevalent but have infrequently been studied collectively. Genetic influences have been suggested to be causally implicated. Surveys were sent to 3909 Australian twin families, assessing the lifetime prevalence of growing pains, migraine, headache, recurrent abdominal pain, low back pain, and persistent pain (not otherwise specified) in pediatric twins and their immediate family members. Comparisons between monozygous (MZ) and dizygous (DZ) twin pair correlations, concordances and odds ratios were performed to assess the contribution of additive genetic influences. Random-effects logistic regression modelling was used to evaluate relationships between twin individuals and their co-twins, mothers, fathers and oldest siblings with the subject conditions. Twin analyses of responses from 1016 families revealed significant influence of additive genetic effects on the presence of growing pains, migraine, and recurrent abdominal pain. The analyses for headache, low back pain, and persistent pain overall did not conclusively demonstrate that genetic influences were implicated more than shared environmental factors. Regression analyses demonstrated varying levels of significance in relationships between family members and twin individuals for the tested conditions, with strongest support for genetic influences in growing pains and migraine. These data, together with previously published association analyses, suggest common causal influences including genes.

scholarly journals Low Back Pain After Sudden Onset of Abdominal Pain in a Patient with Crohn's Disease

2016 ◽  
Vol 129 (4) ◽  
pp. e9-e10
Author(s):  
Kiyoshi Shikino ◽  
Shingo Suzuki ◽  
Yuta Hirose ◽  
Yoshiyuki Ohira ◽  
Masatomi Ikusaka
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Crohn's Disease ◽  
Sudden Onset ◽  
Low Back

scholarly journals The Understanding persistent Pain Where it ResiDes study of low back pain cohort profile

2021 ◽  
Author(s):  
Luke C Jenkins ◽  
Wei-Ju Chang ◽  
Valentina Buscemi ◽  
Matthew Liston ◽  
Michael Nicholas ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Pain Catastrophizing ◽  
Persistent Pain ◽  
Moderate Physical Activity ◽  
Low Back ◽  
Baseline Characteristics

Background: Despite chronic low back pain (LBP) being considered a biopsychosocial condition for diagnosis and management, few studies have investigated neurophysiological and neuro-biological risk factors thought to underpin the transition from acute to chronic LBP. The aim of this cohort profile is to describe the methodology, compare baseline characteristics between acute LBP participants and pain-free controls, and compare LBP participants with or without completed follow-up. Methods: 120 individuals experiencing acute LBP and 57 pain-free controls were recruited to participate in the Understanding Persistent Pain Where it Resides (UPWaRD) study. Screening was conducted via email and phone. Neuro-biological, psychological, and sociodemographic data were collected at baseline, three- and six-months. LBP status was assessed using the numerical rating scale and Roland-Morris disability questionnaire at three and six-month follow-up. Results: 95 participants (79%) provided outcome data at three-month follow-up and 96 participants (80%) at six-months. Participants who did not complete follow-up at three- and six-months within the UPWaRD LBP cohort had higher psychological distress, higher pain interference, higher levels of moderate physical activity, and reported occupational difficulties due to pain (P = <0.05). Compared to controls, LBP participants in the UPWaRD cohort were older, had a higher BMI, a higher prevalence of comorbidities and higher medication usage. Higher depression, anxiety and stress, lower pain self-efficacy and higher pain catastrophizing during acute LBP were correlated with higher six-month pain and disability (P = < 0.01). Conclusions: This cohort profile reports baseline characteristics of the UPWaRD LBP and pain-free control cohort.

Psycho-sensory relationships in chronic pain

2020 ◽  
pp. 204946372093392
Author(s):  
Daniel S Harvie ◽  
Daniela Vasco ◽  
Michele Sterling ◽  
Samantha Low-Choy ◽  
Nils G Niederstrasser
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Standard Deviation ◽  
Neck Pain ◽  
Pain Intensity ◽  
Persistent Pain ◽  
Low Back ◽  
Standard Deviation Increase ◽  
Psychological Variables ◽  
Pain Catastrophising

Background: Psychological variables contribute to pain- and injury-related outcomes. We examined the hypothesis that anatomical spread and intensity of persistent pain relate to anxiety-related variables: generalised anxiety, fear of pain and pain catastrophising. Methods: An online survey was used to gather data from 413 women with persistent pain (low back pain, n = 139; fibromyalgia syndrome, n = 95; neck pain, n = 55; whiplash, n = 41; rheumatoid arthritis, n = 37; migraine, n = 46). The spread and intensity of pain were assessed using the McGill pain chart and a Numerical Rating Scale. A Bayesian Structural Equation Model assessed if the intensity and spread of pain increased with anxiety-related variables. Men were also surveyed (n = 80), but the sample size was only sufficient for analysing if their data were consistent with the model for women. Results: Across subgroups of women, one standard deviation increase in catastrophising, generalised anxiety and fear corresponded to 27%, 7% and −1% additional pain areas and a 1.1, 0 and –0.1 change in pain intensity (on 0–10 scale), respectively. Overall, our clinical significance criterion – a 30% shift in pain variable in relation to one standard deviation increase in psychological variable – was not met. However, in subgroups it was met for pain spread (low back pain, neck pain and migraine) and pain intensity (migraine and neck pain) in relation to pain catastrophising. The model generally had low goodness-of-fit to men. Conclusion: These data support a meaningful relationship between some anxiety-related variables and pain in women for some conditions. Since the model did not consistently fit the men, we may conclude that the relationships are moderated by sex. Clinician attention to psychological variables as potential contributing factors can be justified; however, research is needed to understand the relationship and whether psychological treatment can reduce pain.

Sign in / Sign up

Export Citation Format

Share Document