Comment on Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4

Yihao Shen; Yang Shi; Zhongke Sun

doi:10.3390/foods9040519

Comment on Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4

Foods ◽

10.3390/foods9040519 ◽

2020 ◽

Vol 9 (4) ◽

pp. 519

Author(s):

Yihao Shen ◽

Yang Shi ◽

Zhongke Sun

Keyword(s):

Experimental Determination ◽

Threshold Dose ◽

Dose Effect ◽

Bifidogenic Effect

Currently, our group is undertaking a program trying to evaluate the bifidogenic effect/activity of different prebiotics and their dose-effect relationships [...]

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Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats

Foods ◽

10.3390/foods9010004 ◽

2019 ◽

Vol 9 (1) ◽

pp. 4 ◽

Cited By ~ 3

Author(s):

Ayako Watanabe ◽

Yoshihiro Kadota ◽

Hijiri Yokoyama ◽

Shunya Tsuruda ◽

Rina Kamio ◽

...

Keyword(s):

Small Intestine ◽

Experimental Determination ◽

Gut Bacteria ◽

Threshold Dose ◽

Minimum Dose

1-Kestose is a non-digestible oligosaccharide consisting of glucose linked to two fructose units. While 1-kestose is not digested in the small intestine of mammals, it is fermented in the ceca and colon, where the growth of bifidobacteria is promoted. In the present study, we assessed the threshold dose of dietary 1-kestose that increased cecal bifidobacterial levels in rats. Rats were fed experimental diets containing 0% to 0.3% 1-kestose for four weeks. The levels of the genus Bifidobacterium and total gut bacteria were significantly increased in cecal samples of rats fed the 0.3% 1-kestose diet. Further, a significant correlation between the dose of 1-kestose and the levels of cecal Bifidobacterium and total gut bacteria was observed. The minimum dose of dietary 1-kestose to induce significant bifidogenic activity in rats was 0.3% by weight in the diet.

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Reply to Comment on Watanabe, A.; Kadota, Y.; Yokoyama, H.; Tsuruda, S.; Kamio, R.; Tochio, T.; Shimomura, Y.; Kitaura, Y. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4

Foods ◽

10.3390/foods9040527 ◽

2020 ◽

Vol 9 (4) ◽

pp. 527

Author(s):

Ayako Watanabe ◽

Yoshihiro Kadota ◽

Takumi Tochio ◽

Yoshiharu Shimomura ◽

Yasuyuki Kitaura

Keyword(s):

Experimental Determination ◽

Threshold Dose

The manuscript entitled “Comment on Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats” by Shen et al [...]

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