scholarly journals Cinnamomum cassia Essential Oil Inhibits α-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells

2013 ◽  
Vol 14 (9) ◽  
pp. 19186-19201 ◽  
Author(s):  
Su-Tze Chou ◽  
Wen-Lun Chang ◽  
Chen-Tien Chang ◽  
Shih-Lan Hsu ◽  
Yu-Che Lin ◽  
...  
2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110192
Author(s):  
Yuki Ohno ◽  
Shiori Kondo ◽  
Kiho Tajima ◽  
Toshiyuki Shibata ◽  
Tomohiro Itoh

Phlorotannins isolated from brown algae, such as Eisena bicyclis, have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease. Although phlorotannins have been shown to inhibit tyrosinase, an enzyme essential for melanogenesis, their effect on melanogenesis remains unexplored. Thus, we isolated phlorotannins from E. bicyclis and examined their effects on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in murine B16 melanoma cells. Both fucofuroeckol-A (FF-A) and phlorofucofuroeckol-A (PFF-A) suppressed α-MSH-induced melanogenesis. Neither inhibited human tyrosinase (TYR) activity, but both inhibited tyrosinase-related protein-2 activity. FF-A downregulated the expression of microphthalmia-associated transcription factor and TYR, which subsequently suppressed melanin production. These results suggest that phlorotannins could be beneficial as melanin control drugs for hyperpigmentation disorders.


2015 ◽  
Vol 37 (5) ◽  
pp. 550-554 ◽  
Author(s):  
C.-H. Yang ◽  
Y.-C. Huang ◽  
M.-L. Tsai ◽  
C.-Y. Cheng ◽  
L.-L. Liu ◽  
...  

2017 ◽  
Vol 46 (3) ◽  
pp. 320-326 ◽  
Author(s):  
Bo Yeon Shin ◽  
Bo Ram Jung ◽  
Jong Gi Jung ◽  
Seung Sik Cho ◽  
Mi Ae Bang

Planta Medica ◽  
2009 ◽  
Vol 75 (14) ◽  
pp. 1505-1508 ◽  
Author(s):  
Cheong-Yong Yun ◽  
Dongchun Kim ◽  
Won-Hee Lee ◽  
Yu Park ◽  
Seung Lee ◽  
...  

2017 ◽  
Vol 81 (3) ◽  
pp. 534-540 ◽  
Author(s):  
Ichiro Yoshida ◽  
Chihiro Ito ◽  
Shinya Matsuda ◽  
Akihiko Tsuji ◽  
Noriyuki Yanaka ◽  
...  

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