Acetoside inhibits α-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase

2009 ◽  
Vol 61 (10) ◽  
pp. 1347-1351 ◽  
Author(s):  
Ho Sun Song ◽  
Sang Soo Sim
Keyword(s):  
Melanoma Cells ◽  
Adenyl Cyclase ◽  
B16 Melanoma ◽  
Melanin Production ◽  
B16 Melanoma Cells

scholarly journals Effect of Phlorotannins Isolated From Eisenia bicyclis on Melanogenesis in Mouse B16 Melanoma Cells

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110192
Author(s):  
Yuki Ohno ◽  
Shiori Kondo ◽  
Kiho Tajima ◽  
Toshiyuki Shibata ◽  
Tomohiro Itoh
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Physiological Effects ◽  
Related Protein ◽  
Eisenia Bicyclis ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Anti Cancer ◽  
Tyrosinase Related Protein

Phlorotannins isolated from brown algae, such as Eisena bicyclis, have positive physiological effects, including anti-cancer, anti-inflammatory, and anti-Alzheimer’s disease. Although phlorotannins have been shown to inhibit tyrosinase, an enzyme essential for melanogenesis, their effect on melanogenesis remains unexplored. Thus, we isolated phlorotannins from E. bicyclis and examined their effects on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in murine B16 melanoma cells. Both fucofuroeckol-A (FF-A) and phlorofucofuroeckol-A (PFF-A) suppressed α-MSH-induced melanogenesis. Neither inhibited human tyrosinase (TYR) activity, but both inhibited tyrosinase-related protein-2 activity. FF-A downregulated the expression of microphthalmia-associated transcription factor and TYR, which subsequently suppressed melanin production. These results suggest that phlorotannins could be beneficial as melanin control drugs for hyperpigmentation disorders.

Inhibitory Effects on Melanin Production in B16 Melanoma Cells of Fallen Pear

2017 ◽  
Vol 46 (3) ◽  
pp. 320-326 ◽  
Author(s):  
Bo Yeon Shin ◽  
Bo Ram Jung ◽  
Jong Gi Jung ◽  
Seung Sik Cho ◽  
Mi Ae Bang
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Inhibitory Effects ◽  
Melanin Production ◽  
B16 Melanoma Cells

Torilin fromTorilis japonicaInhibits Melanin Production in α-Melanocyte Stimulating Hormone-Activated B16 Melanoma Cells

Planta Medica ◽  
2009 ◽  
Vol 75 (14) ◽  
pp. 1505-1508 ◽  
Author(s):  
Cheong-Yong Yun ◽  
Dongchun Kim ◽  
Won-Hee Lee ◽  
Yu Park ◽  
Seung Lee ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Production ◽  
Melanocyte Stimulating Hormone ◽  
B16 Melanoma Cells ◽  
Stimulating Hormone

scholarly journals Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells

2017 ◽  
Vol 81 (3) ◽  
pp. 534-540 ◽  
Author(s):  
Ichiro Yoshida ◽  
Chihiro Ito ◽  
Shinya Matsuda ◽  
Akihiko Tsuji ◽  
Noriyuki Yanaka ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Production ◽  
B16 Melanoma Cells ◽  
Alisma Orientale ◽  
Alismatis Rhizoma

scholarly journals Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2697
Author(s):  
Thouria Bourhim ◽  
Myra O. Villareal ◽  
Chemseddoha Gadhi ◽  
Hiroko Isoda
Keyword(s):  
Signaling Pathways ◽  
Press Cake ◽  
Global Gene Expression ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Dependent Manner ◽  
Melanin Biosynthesis ◽  
B16 Melanoma Cells ◽  
Pigmentary Disorders ◽  
Argan Oil

The beneficial effect on health of argan oil is recognized worldwide. We have previously reported that the cake that remains after argan oil extraction (argan press-cake or APC) inhibits melanogenesis in B16 melanoma cells in a time-dependent manner without cytotoxicity. In this study, the global gene expression profile of B16 melanoma cells treated with APC extract was determined in order to gain an understanding of the possible mechanisms of action of APC. The results suggest that APC extract inhibits melanin biosynthesis by down-regulating microphthalmia-associated transcription factor (Mitf) and its downstream signaling pathway through JNK signaling activation, and the inhibition of Wnt/β-catenin and cAMP/PKA signaling pathways. APC extract also prevented the transport of melanosomes by down-regulating Rab27a expression. These results suggest that APC may be an important natural skin whitening product and pharmacological agent used for clinical treatment of pigmentary disorders.

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