scholarly journals The Role of CzcRS Two-Component Systems in the Heavy Metal Resistance of Pseudomonas putida X4

2015 ◽  
Vol 16 (8) ◽  
pp. 17005-17017 ◽  
Author(s):  
Pulin Liu ◽  
Xi Chen ◽  
Qiaoyun Huang ◽  
Wenli Chen
Author(s):  
E. Naomab ◽  
S. Gattolin ◽  
M. Alandete-Saez ◽  
K. Elliott ◽  
Z. Gonzalez-Carranza ◽  
...  

2019 ◽  
Vol 73 (1) ◽  
pp. 199-223 ◽  
Author(s):  
Vanessa I. Francis ◽  
Steven L. Porter

Bacteria depend on two-component systems to detect and respond to threats. Simple pathways comprise a single sensor kinase (SK) that detects a signal and activates a response regulator protein to mediate an appropriate output. These simple pathways with only a single SK are not well suited to making complex decisions where multiple different stimuli need to be evaluated. A recently emerging theme is the existence of multikinase networks (MKNs) where multiple SKs collaborate to detect and integrate numerous different signals to regulate a major lifestyle switch, e.g., between virulence, sporulation, biofilm formation, and cell division. In this review, the role of MKNs and the phosphosignaling mechanisms underpinning their signal integration and decision making are explored.


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