scholarly journals Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors

2018 ◽  
Vol 19 (7) ◽  
pp. 2017 ◽  
Author(s):  
Soumaya Kouidhi ◽  
Marie-Stéphanie Clerget-Froidevaux
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors ◽  
Hormone Signaling ◽  
Hypothalamic Control

scholarly journals In vitro assessment of the capacity of pesticides to act as agonists/antagonists of the thyroid hormone nuclear receptors

2020 ◽  
Author(s):  
Yanis Zekri ◽  
Laure Dall Agnol ◽  
Frédéric Flamant ◽  
Romain Guyot
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors ◽  
Transcriptome Analysis ◽  
Cellular Response ◽  
In Vitro Tests ◽  
Neural Cells ◽  
Hormone Signaling ◽  
Neurodevelopmental Toxicity ◽  
In Vitro Assessment

SummarySeveral in vitro tests, including transcriptome analysis of neural cells, were performed to assess the capacity of 33 pesticides to act as thyroid hormone disruptors (THD). Although some pesticides elicit a cellular response, which interferes with thyroid hormone signaling, we found no evidence that they can act as receptor agonists or antagonists. We conclude that the nuclear receptors of thyroid hormone are not common targets of THD, and that pesticide neurodevelopmental toxicity is not explained by a general alteration of neural cell response to thyroid hormone.

scholarly journals Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Fabrice Chatonnet ◽  
Frédéric Picou ◽  
Teddy Fauquier ◽  
Frédéric Flamant
Keyword(s):  
Cerebral Cortex ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Glial Cell ◽  
Nuclear Receptors ◽  
Target Genes ◽  
Cell Types ◽  
Hormone Action ◽  
Cerebral Cortex Development ◽  
Thyroid Hormone Action

Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,,5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.

scholarly journals The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison

2017 ◽  
Vol 422 (2) ◽  
pp. 71-82 ◽  
Author(s):  
Seham Skah ◽  
Joel Uchuya-Castillo ◽  
Maria Sirakov ◽  
Michelina Plateroti
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors

scholarly journals Thyroid Hormone Signaling in the Mouse Retina

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168003 ◽  
Author(s):  
Patrick Arbogast ◽  
Frédéric Flamant ◽  
Pierre Godement ◽  
Martin Glösmann ◽  
Leo Peichl
Keyword(s):  
Thyroid Hormone ◽  
Mouse Retina ◽  
Hormone Signaling

scholarly journals microRNA and thyroid hormone signaling in cardiac and skeletal muscle

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Duo Zhang ◽  
Yan Li ◽  
Shengnan Liu ◽  
Yu-cheng Wang ◽  
Feifan Guo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Hormone Signaling

scholarly journals The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

2013 ◽  
Vol 14 (8) ◽  
pp. 16240-16257 ◽  
Author(s):  
Adam Brown ◽  
Rosalia Simmen ◽  
Frank Simmen
Keyword(s):  
Thyroid Hormone ◽  
Digestive System ◽  
Hormone Signaling
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