scholarly journals Mitogen-Activated Protein Kinases: Functions in Signal Transduction and Human Diseases

2019 ◽  
Vol 20 (19) ◽  
pp. 4844 ◽  
Author(s):  
Ritva Tikkanen ◽  
David J. Nikolic-Paterson
Keyword(s):  
Signal Transduction ◽  
Growth Factors ◽  
Protein Kinases ◽  
Human Diseases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

Mitogen-activated protein kinases (MAPKs) are involved in signaling processes induced by various stimuli, such as growth factors, stress, or even autoantibodies [...]

scholarly journals Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability

2019 ◽  
Vol 20 (11) ◽  
pp. 2668 ◽  
Author(s):  
Hsueh-Fen Chen ◽  
Huai-Chia Chuang ◽  
Tse-Hua Tan
Keyword(s):  
Signal Transduction ◽  
Protein Stability ◽  
Protein Kinases ◽  
Post Translational Modifications ◽  
Mitogen Activated Protein Kinases ◽  
Cell Responses ◽  
Dual Specificity ◽  
Duration Magnitude ◽  
Mitogen Activated Protein ◽  
Dual Specificity Phosphatases

Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or spatiotemporal profiles of MAPK activities. Hence, DUSPs need to be properly controlled. Protein post-translational modifications, such as ubiquitination, phosphorylation, methylation, and acetylation, play important roles in the regulation of protein stability and activity. Ubiquitination is critical for controlling protein degradation, activation, and interaction. For DUSPs, ubiquitination induces degradation of eight DUSPs, namely, DUSP1, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, and DUSP16. In addition, protein stability of DUSP2 and DUSP10 is enhanced by phosphorylation. Methylation-induced ubiquitination of DUSP14 stimulates its phosphatase activity. In this review, we summarize the knowledge of the regulation of DUSP stability and ubiquitination through post-translational modifications.

TP5 Triggers Signal Transduction Involving Mitogen Activated Protein Kinases in Monocytes

1999 ◽  
Vol 19 (1-4) ◽  
pp. 155-166 ◽  
Author(s):  
S. Gonser ◽  
N. E. A. Crompton ◽  
P. J. A. Weber ◽  
A. G. Beck-Sickinger ◽  
G. Folkers
Keyword(s):  
Signal Transduction ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals Growth Factors and Mitogen-Activated Protein Kinases

Hypertension ◽  
1998 ◽  
Vol 31 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Thomas Force ◽  
Joseph V. Bonventre
Keyword(s):  
Growth Factors ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

Signal Transduction by Mitogen-activated Protein Kinases (MAPKs)

2001 ◽  
pp. 321-330
Author(s):  
Erwin Heberle-Bors ◽  
Ornella Calderini ◽  
Viktor Voronin ◽  
Cathal Wilson
Keyword(s):  
Signal Transduction ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein
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