scholarly journals Interplay between Cytokine Circuitry and Transcriptional Regulation Shaping Helper T Cell Pathogenicity and Plasticity in Inflammatory Bowel Disease

2020 ◽  
Vol 21 (9) ◽  
pp. 3379 ◽  
Author(s):  
Shin-Huei Fu ◽  
Ming-Wei Chien ◽  
Chao-Yuan Hsu ◽  
Yu-Wen Liu ◽  
Huey-Kang Sytwu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
T Helper Cells ◽  
Intestinal Inflammation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Local Immunity ◽  
Helper Cells ◽  
Inflammatory Bowel

Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn’s disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector or regulatory phenotypes is controlled by cytokine networks and transcriptional regulators. Distinct polarized T helper cells are able to alter their phenotypes to adapt to diverse and fluctuating physiological environments. T helper cells exhibit intrinsic instability and flexibility to express cytokines of other lineages or transdifferentiate from one T helper cell type to another in response to various perturbations from physiological cytokine milieu as a means of promoting local immunity in response to injury or ensure tissue homeostasis. Furthermore, functional plasticity and diversity of T helper cells are associated with pathogenicity and are critical for immune homeostasis and prevention of autoimmunity. In this review, we provide deeper insights into the combinatorial extrinsic and intrinsic signals that control plasticity and transdifferentiation of T helper cells and also highlight the potential of exploiting the genetic reprogramming plasticity of T helper cells in the treatment of IBD.

W1168 A Key Role for the Endocannabinoid System in Dampening T Helper Cell Type 1 Response in Inflammatory Bowel Disease

2008 ◽  
Vol 134 (4) ◽  
pp. A-647
Author(s):  
Antonio Di Sabatino ◽  
Natalia Battista ◽  
Paolo Biancheri ◽  
Paolo Cazzola ◽  
Alessandro Vanoli ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Endocannabinoid System ◽  
T Helper Cell ◽  
Helper Cell ◽  
Cell Type ◽  
T Helper ◽  
Helper Cell Type ◽  
Inflammatory Bowel

Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease

2014 ◽  
Vol 20 (12) ◽  
pp. 2321-2329 ◽  
Author(s):  
Anna-Maria Globig ◽  
Nadine Hennecke ◽  
Bianca Martin ◽  
Maximilian Seidl ◽  
Günther Ruf ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Bowel Disease ◽  
Cd4 T Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Specific Accumulation ◽  
Inflammatory Bowel ◽  
Ifn Γ

Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis

2016 ◽  
Vol 66 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Ying-Ying Chen ◽  
Rui-Yan Li ◽  
Mei-Jing Shi ◽  
Ya-Xing Zhao ◽  
Yan Yan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Cell Homeostasis ◽  
Inflammatory Bowel

T helper cell subsets, key cytokines and chemokines in the pathogenesis of inflammatory bowel disease (Part 1)

2020 ◽  
Vol 15 (6) ◽  
pp. 67-78
Author(s):  
T.Ya. Vakhitov ◽  
◽  
I.V. Kudryavtsev ◽  
T.S. Sall ◽  
N.M. Lazareva ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Cytokines And Chemokines ◽  
Th Cell ◽  
Inflammatory Bowel

This review summarizes the current scientific evidence on the role of different T helper (Th) cell subsets, key cytokines, and chemokines in inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. According to modern concepts, not only type Th1, but also Th17, cytokines, and other cells of innate and adaptive immunity are involved in the immunopathogenesis of IBD. Most of the review is devoted to the current understanding of the role of polarized Th17 cells and subpopulations of follicular Th cells, the main function of which is to form a specific humoral immune response in IBD mediated by B cells. The role of the intestinal microbiota in the Th cell polarization, that is, their differentiation, accompanied by the acquisition of characteristics inherent in a particular subpopulation is discussed. The presented data are important for understanding the role of immune processes, including microbiome-associated ones, in the pathogenesis of IBD. Key words: inflammatory bowel disease, ulcerative colitis, Crohn’s disease, T helper cell subsets, cytokines, chemokines, gut microbiome

scholarly journals Generation of IL-8 and IL-9 Producing CD4+T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Michaela Gasch ◽  
Tina Goroll ◽  
Mario Bauer ◽  
Denise Hinz ◽  
Nicole Schütze ◽  
...  
Keyword(s):  
T Cells ◽  
T Helper Cells ◽  
Th17 Cells ◽  
Immune Cell ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Helper Cells ◽  
Aryl Hydrocarbon

The T helper cell subsets Th1, Th2, Th17, and Treg play an important role in immune cell homeostasis, in host defense, and in immunological disorders. Recently, much attention has been paid to Th17 cells which seem to play an important role in the early phase of the adoptive immune response and autoimmune disease. When generating Th17 cells underin vitroconditions the amount of IL-17A producing cells hardly exceeds 20% while the nature of the remaining T cells is poorly characterized. As engagement of the aryl hydrocarbon receptor (AHR) has also been postulated to modulate the differentiation of T helper cells into Th17 cells with regard to the IL-17A expression we ask how far do Th17 polarizing conditions in combination with ligand induced AHR activation have an effect on the production of other T helper cell cytokines. We found that a high proportion of T helper cells cultured under Th17 polarizing conditions are IL-8 and IL-9 single producing cells and that AHR activation results in an upregulation of IL-8 and a downregulation of IL-9 production. Thus, we have identified IL-8 and IL-9 producing T helper cells which are subject to regulation by the engagement of the AHR.

scholarly journals Generation of T-helper cells in vitro. II. Analysis of supernates derived from T-helper cell cultures.

1977 ◽  
Vol 145 (3) ◽  
pp. 693-708 ◽  
Author(s):  
J S McDougal ◽  
D S Gordon
Keyword(s):  
Cell Cultures ◽  
T Helper Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
Accessory Cell ◽  
T Helper ◽  
Spleen Cells ◽  
Helper Cells ◽  
Cell Carrier

Supernates derived from in vitro generated T-helper cells have been analyzed for their capacity to substitute for T-cell carrier reactivity. T-helper cell supernates stimulate both a carrier-specific and nonspecific anti-DNP-PFC response to DNP-carrier conjugates in cultures of hapten-primed spleen cells. The carrier-specific and nonspecific activity can be distinguished by dosage optimum, antigen requirements, binding specificity for carrier, and in the requirement for additional splenic adherent accessory cell involvement. The active factors produced in this system are heat labile and sensitive to trypsin and periodate. They are removed by absorption with alloantisera directed toward the strain from which the supernate was derived but not by a variety of anti-immunoglobulin sera.

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